2025
Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell
Zapadka T, Tran N, Demb J. Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell. The Journal Of Physiology 2025 PMID: 39985791, DOI: 10.1113/jp286414.Peer-Reviewed Original ResearchOptic nerve crushRetinal ganglion cellsOptic nerveGanglion cellsSynaptic inputsVoltage-gated sodium channel currentsRetinal ganglion cell typesVoltage-gatedRetinal ganglion cell survivalChelation of intracellular calciumResting membrane potentialOptic nerve injuryVoltage-gated currentsAxonal injurySodium channel currentsRetinal ganglion cell axonsRGC typesAlpha retinal ganglion cellsAxon initial segmentIntracellular calciumRate of survivalNerve injuryElectrophysiological propertiesNerve crushIntrinsic excitability
2022
Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma
Sekine Y, Kannan R, Wang X, Strittmatter SM. Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma. Experimental Neurology 2022, 353: 114070. PMID: 35398339, PMCID: PMC9555232, DOI: 10.1016/j.expneurol.2022.114070.Peer-Reviewed Original ResearchConceptsAxon regenerationModerate spinal cord contusion injurySpinal cord contusion injuryTraumatic spinal cord injuryAdult mammalian central nervous systemGrowth conesRetinal ganglion cell axonsOptic nerve crushSpinal cord crush injuryGanglion cell axonsSpinal cord injuryMammalian central nervous systemCentral nervous systemCorticospinal axon regenerationContusion injuryAxonal sproutingCrush injuryNerve crushAxonal growth conesCord injuryAxon sproutingCell axonsProximal bodyNervous systemNeural repair
2019
Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination
Lee JY, Kim MJ, Thomas S, Oorschot V, Ramm G, Aui PM, Sekine Y, Deliyanti D, Wilkinson-Berka J, Niego B, Harvey AR, Theotokis P, McLean C, Strittmatter SM, Petratos S. Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination. Journal Of Neuroscience 2019, 39: 5562-5580. PMID: 31061088, PMCID: PMC6616297, DOI: 10.1523/jneurosci.1760-18.2019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsAxonal TransportAxonsCells, CulturedEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansIntercellular Signaling Peptides and ProteinsKinesinsMaleMiceMice, Inbred C57BLMiddle AgedMyelin SheathNerve Tissue ProteinsNogo Receptor 1Retinal Ganglion CellsSignal TransductionConceptsExperimental autoimmune encephalomyelitisCollapsin response mediator protein 2Optic nerveAxonal degenerationMultiple sclerosisAxonal vesicular transportAutoimmune encephalomyelitisInflammatory demyelinationAxonal integritySeverity of EAECre deletionAxonal transportRetinal ganglion cell axonsAxonal motor proteinsEAE-induced miceImmune-mediated destructionProgressive multiple sclerosisNeuron-specific deletionNogo receptor 1Ganglion cell axonsAnterograde transportFlx/Response mediator protein 2Adeno-associated virus serotype 2Phosphorylation of CRMP2
2014
BDNF Promotes Axon Branching of Retinal Ganglion Cells via miRNA-132 and p250GAP
Marler KJ, Suetterlin P, Dopplapudi A, Rubikaite A, Adnan J, Maiorano NA, Lowe AS, Thompson ID, Pathania M, Bordey A, Fulga T, Van Vactor DL, Hindges R, Drescher U. BDNF Promotes Axon Branching of Retinal Ganglion Cells via miRNA-132 and p250GAP. Journal Of Neuroscience 2014, 34: 969-979. PMID: 24431455, PMCID: PMC3891972, DOI: 10.1523/jneurosci.1910-13.2014.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorRetinal culturesMiRNA-132Neurotrophin brain-derived neurotrophic factorRetinal ganglion cell axonsAxon branchingGanglion cell axonsRetinal ganglion cellsMouse superior colliculusBDNF actionBDNF treatmentNeurotrophic factorRGC axonsTopographic targetingGanglion cellsCell axonsSuperior colliculusExpression of microRNAsTermination zonesP250GAPProtein levelsVertebrate visual systemAxonsUpregulationMap formation
2009
Consequences of axon guidance defects on the development of retinotopic receptive fields in the mouse colliculus
Chandrasekaran AR, Furuta Y, Crair MC. Consequences of axon guidance defects on the development of retinotopic receptive fields in the mouse colliculus. The Journal Of Physiology 2009, 587: 953-963. PMID: 19153163, PMCID: PMC2673768, DOI: 10.1113/jphysiol.2008.160952.Peer-Reviewed Original ResearchConceptsSuperior colliculusMutant miceBone morphogenetic protein receptorRetinal ganglion cell axonsGuidance moleculesSpontaneous retinal wavesGanglion cell axonsSuperficial superior colliculusReceptive field propertiesRetinotopic receptive fieldsActivity-dependent factorsMore RGCsRetinocollicular projectionRetinal wavesEctopic projectionsVentral retinaCell axonsRetinotopic map formationAnatomical defectsAction potentialsActivity-dependent learning ruleSpontaneous wavesRetinaRGCsMice
2008
Structural Requirement of TAG-1 for Retinal Ganglion Cell Axons and Myelin in the Mouse Optic Nerve
Chatzopoulou E, Miguez A, Savvaki M, Levasseur G, Muzerelle A, Muriel M, Goureau O, Watanabe K, Goutebroze L, Gaspar P, Zalc B, Karagogeos D, Thomas J. Structural Requirement of TAG-1 for Retinal Ganglion Cell Axons and Myelin in the Mouse Optic Nerve. Journal Of Neuroscience 2008, 28: 7624-7636. PMID: 18650339, PMCID: PMC6670848, DOI: 10.1523/jneurosci.1103-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAxonsCell Adhesion Molecules, NeuronalCells, CulturedContactin 2Embryo, MammalianGene Expression Regulation, DevelopmentalLeukocyte L1 Antigen ComplexMiceMice, KnockoutMyelin SheathNerve Tissue ProteinsNeurogliaOptic NerveRetinaRetinal Ganglion CellsTranscription Factor Brn-3AConceptsOptic nerveRetinal ganglion cellsRGC axonsTAG-1Retinal ganglion cell axonsEmbryonic retinal ganglion cellsGanglion cell axonsMouse optic nerveLateral geniculate nucleusWhite matter axonsMyelin-forming cellsPersistent abnormalitiesGanglion cellsGlial cellsCell adhesion moleculeContralateral projectionsGeniculate nucleusCell axonsAstroglial networksRetinal axonsNerveAxonal tractsAxonal caliberMyelination defectsAxonsBone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse
Plas DT, Dhande OS, Lopez JE, Murali D, Thaller C, Henkemeyer M, Furuta Y, Overbeek P, Crair MC. Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse. Journal Of Neuroscience 2008, 28: 7057-7067. PMID: 18614674, PMCID: PMC2667968, DOI: 10.1523/jneurosci.3598-06.2008.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusSuperior colliculusOptic tractRetinotopic map formationRetinal ganglion cell axonsBone morphogenetic proteinCentral brain targetsRetinocollicular map formationGanglion cell axonsMap formationWild-type miceStrains of miceAxon behaviorEarly eye formationAxon orderRetinal cell fateOptic chiasmRGC axonsBrain targetsGeniculate nucleusCell axonsPotential downstream effectorsAxon sortingMorphogenetic proteinsMice
2005
Pretarget sorting of retinocollicular axons in the mouse
Plas DT, Lopez JE, Crair MC. Pretarget sorting of retinocollicular axons in the mouse. The Journal Of Comparative Neurology 2005, 491: 305-319. PMID: 16175549, PMCID: PMC2716708, DOI: 10.1002/cne.20694.Peer-Reviewed Original ResearchConceptsRetinotopic orderOptic tractRetinotectal mapRetinal ganglion cell axonsGanglion cell axonsWild-type miceAxon orderRetinocollicular axonsMouse genetic modelsCell axonsTectal mapMouse modelRetinal axonsOptic tectumSubsequent tractsAxonsTarget cellsTractMiceVertebrate visual systemTectumRetinaRoger SperryGenetic modelsLipophilic dye
2004
Neogenin mediates the action of repulsive guidance molecule
Rajagopalan S, Deitinghoff L, Davis D, Conrad S, Skutella T, Chedotal A, Mueller BK, Strittmatter SM. Neogenin mediates the action of repulsive guidance molecule. Nature Cell Biology 2004, 6: 756-762. PMID: 15258590, DOI: 10.1038/ncb1156.Peer-Reviewed Original ResearchConceptsRepulsive guidance moleculeRetinal ganglion cell axonsGuidance moleculesGanglion cell axonsDorsal root ganglion axonsTemporal retinal axonsVisual map formationReceptor mechanismsCell axonsNeogenin expressionRetinal axonsGanglion axonsAxonal responsivenessOptic tectumChick retinaNeogeninSub-nanomolar affinityAxonsAxonal guidanceNeogenin functionsResponsive stateNeural tubeMap formationExpressionRetina
2002
Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.
Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 2002, 129: 467-77. PMID: 11807038, DOI: 10.1242/dev.129.2.467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCell DifferentiationCulture TechniquesDNA-Binding ProteinsFemaleGene TargetingHumansMaleMiceMice, KnockoutMicroscopy, FluorescenceNeuritesRetinaRetinal Ganglion CellsTranscription Factor Brn-3Transcription Factor Brn-3ATranscription Factor Brn-3BTranscription Factor Brn-3CTranscription FactorsConceptsDouble knockout miceGanglion cell differentiationRetinal ganglion cell differentiationRetinal ganglion cellsOptic chiasmKnockout miceGanglion cellsMost retinal ganglion cellsRetinal ganglion cell axonsRetinal ganglion cell developmentGanglion cell axonsAxon outgrowthGanglion cell developmentCell differentiationDorsal rootsProjection neuronsTrigeminal ganglionCell axonsRetinal explantsPOU domain transcription factorBrn3bBrn3cMiceChiasmInner ear
1985
Development of the rhesus monkey retina. I. Emergence of the inner plexiform layer and its synapses
Nishimura Y, Rakic P. Development of the rhesus monkey retina. I. Emergence of the inner plexiform layer and its synapses. The Journal Of Comparative Neurology 1985, 241: 420-434. PMID: 4078040, DOI: 10.1002/cne.902410403.Peer-Reviewed Original ResearchConceptsInner plexiform layerConventional synapsesPlexiform layerGeniculate nucleusRibbon synapsesRhesus monkeysAdult levelsDorsal lateral geniculate nucleusRetinal ganglion cell axonsRhesus monkey retinaGanglion cell axonsSynaptic vesiclesLateral geniculate nucleusRate of synaptogenesisGap junctionsSynaptic contactsMonkey retinaCell axonsRetinal projectionsSuperior colliculusAcellular zoneChemical synapsesSynaptogenesisImmature neuritesSynapses
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