2025
CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models
Leser F, Júnyor F, Pagnoncelli I, Delgado A, Medeiros I, Nóbrega A, Andrade B, de Lima M, da Silva N, Jacob L, Boyé K, Geraldo L, de Souza A, Maron-Gutierrez T, Castro-Faria-Neto H, Follmer C, Braga C, Neves G, Eichmann A, Romão L, Lima F. CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models. Journal Of Neuroinflammation 2025, 22: 31. PMID: 39894839, PMCID: PMC11789347, DOI: 10.1186/s12974-024-03318-x.Peer-Reviewed Original ResearchConceptsMouse model of PDModel of PDMouse modelDopaminergic neuronsNeuron-microglia communicationNeuron-glia communicationParkinson's diseaseCCR7-dependent mannerMicroglial cell activationCCR7 expressionCCL21-CCR7Progressive degenerative diseaseCCR7 receptorMicroglial cell migrationInflammatory profileChemokine CCL21Cell activationCCL21Therapeutic strategiesChemokine inhibitorsTherapeutic implicationsMicroglial activationReceptor pathwayCCR7Behavioral deficits
2024
Management of Incomplete Microcirculatory Reperfusion After Endovascular Thrombectomy: Focus on Inhibition of the Glycoprotein IIb/IIIa Receptor Pathway
Krothapalli N, Ortel T, McBride D, de Havenon A, Sansing L, Hasan D, Mac Grory B. Management of Incomplete Microcirculatory Reperfusion After Endovascular Thrombectomy: Focus on Inhibition of the Glycoprotein IIb/IIIa Receptor Pathway. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.123.001048.Peer-Reviewed Original ResearchMicrocirculatory reperfusionEndovascular thrombectomyAdministration of tirofibanDigital subtraction angiographyLarge-vessel occlusionProportion of casesRescue therapyTherapeutic optionsAntiplatelet therapyClinical outcomesUnfavorable outcomeEndothelial edemaSubtraction angiographyEffective therapyIntraarterial administrationClinical challengeReceptor pathwayPlatelet aggregationTreatment approachesTherapyReperfusionCerebral microvasculatureTissue recoveryNeurological diseasesThrombectomy
2023
Biomolecular Condensation of SH2 Domain-Containing Proteins on Membranes
Zeng L, Su X. Biomolecular Condensation of SH2 Domain-Containing Proteins on Membranes. Methods In Molecular Biology 2023, 2705: 371-379. PMID: 37668985, DOI: 10.1007/978-1-0716-3393-9_20.Peer-Reviewed Original ResearchConceptsSH2 domainSH2 domain-containing proteinsDomain-containing proteinsT cell receptorReceptors/adaptorsReceptor pathwayContext of membraneEndomembrane systemMembrane receptor pathwaysSignal transductionBiomolecular condensationSpecific tyrosinePlasma membraneReconstitution systemGolgi apparatusEndoplasmic reticulumLiquid-liquid phase separationMultivalent interactionsCondensate formationProteinMembranePathwayPhosphotyrosineAssaysTransduction
2022
Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model
Mat N, Bakar S, Murugaiyah V, Chawarski M, Hassan Z. Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model. Behavioural Brain Research 2022, 439: 114251. PMID: 36503042, DOI: 10.1016/j.bbr.2022.114251.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesAnalgesic effectTRPV1 expressionAcute pain animal modelsEffective doseFemale Sprague-Dawley ratsPain animal modelsPain-like behaviorsNon-opioid receptorsOpioid receptor activationNumber of writhesSprague-Dawley ratsInflammatory painPain pathwaysTRPV1 receptorsDawley ratsWrithing behaviorED95 valuesRat brainAnimal modelsReceptor activationReceptor pathwayRatsBehavior scoresMain indole alkaloids
2021
NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021.
Zelenetz AD, Gordon LI, Chang JE, Christian B, Abramson JS, Advani RH, Bartlett NL, Budde LE, Caimi PF, De Vos S, Dholaria B, Fakhri B, Fayad LE, Glenn MJ, Habermann TM, Hernandez-Ilizaliturri F, Hsi E, Hu B, Kaminski MS, Kelsey CR, Khan N, Krivacic S, LaCasce AS, Lim M, Narkhede M, Rabinovitch R, Ramakrishnan P, Reid E, Roberts KB, Saeed H, Smith SD, Svoboda J, Swinnen LJ, Tuscano J, Vose JM, Dwyer MA, Sundar H. NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021. Journal Of The National Comprehensive Cancer Network 2021, 19: 1218-1230. PMID: 34781267, DOI: 10.6004/jnccn.2021.0054.Peer-Reviewed Original ResearchConceptsB-cell lymphomaNCCN guidelinesAnti-CD19 CAR T-cell therapyB-cell non-Hodgkin lymphomaCAR T-cell therapyB-cell receptor pathwayLarge B-cell lymphomaNCCN Guidelines InsightsRelapsed/refractoryT-cell therapyNon-Hodgkin lymphomaNovel treatment optionsMantle cell lymphomaAntibody-drug conjugatesR diseaseTherapy optionsTreatment optionsCell lymphomaFollicular lymphomaSmall molecule inhibitorsLymphomaMolecular pathogenesisReceptor pathwayMolecule inhibitorsTherapyPLCγ1 promotes phase separation of T cell signaling components
Zeng L, Palaia I, Šarić A, Su X. PLCγ1 promotes phase separation of T cell signaling components. Journal Of Cell Biology 2021, 220: e202009154. PMID: 33929486, PMCID: PMC8094118, DOI: 10.1083/jcb.202009154.Peer-Reviewed Original ResearchConceptsTCR signal transductionT-cell receptor pathwayLiquid-like condensatesKey adaptor proteinLAT clusteringLAT complexSH2 domainAdaptor proteinPhosphatase CD45Signal transductionTCR pathwayPhospholipase Cγ1ERK activationProtein compositionBiophysical principlesPLCγ1Critical functionsReceptor pathwayPathwayLATMajor componentT cellsCellsActivationDephosphorylation
2020
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Immunity 2020, 52: 1007-1021.e8. PMID: 32497523, PMCID: PMC7408742, DOI: 10.1016/j.immuni.2020.05.003.Peer-Reviewed Original ResearchConceptsDouble-stranded RNADeleterious innate immune responseMammalian hematopoietic developmentEndogenous double-stranded RNAHematopoietic developmentInnate immune responseAbundant RNA modificationMurine fetal liverPattern recognition receptor pathwaysImmune responseProtein codingDsRNA formationRNA modificationsWriter METTL3Hematopoietic defectsPerinatal lethalityNative stateConditional deletionAberrant innate immune responsesLoss of METTL3Hematopoietic failureReceptor pathwayAberrant immune responsePrevents formationFetal liver
2019
Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals
Sopeyin A, Zhou L, Li M, Barakat L, Paintsil E. Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals. PLOS ONE 2019, 14: e0226573. PMID: 31846498, PMCID: PMC6917281, DOI: 10.1371/journal.pone.0226573.Peer-Reviewed Original ResearchConceptsTreatment-experienced individualsAntiretroviral therapyCholesterol biosynthesis genesSide effectsEffect of ARTLow density lipoprotein receptor pathwayHIV viral suppressionCase-control studyLipoprotein receptor pathwaySterol regulatory element-binding protein 2Cassette transporter A1Protein expression levelsViral suppressionLipid abnormalitiesClinical manifestationsMetabolic derangementsCardiovascular diseaseRetrospective analysisTherapeutic benefitProtein 2 geneMRNA expressionReceptor pathwayMarked decreaseDysregulationExpression levelsNetwork-based Biased Tree Ensembles (NetBiTE) for Drug Sensitivity Prediction and Drug Sensitivity Biomarker Identification in Cancer
Oskooei A, Manica M, Mathis R, Martínez M. Network-based Biased Tree Ensembles (NetBiTE) for Drug Sensitivity Prediction and Drug Sensitivity Biomarker Identification in Cancer. Scientific Reports 2019, 9: 15918. PMID: 31685861, PMCID: PMC6828742, DOI: 10.1038/s41598-019-52093-w.Peer-Reviewed Original ResearchConceptsMembrane receptor pathwayDrug sensitivity predictionProtein-protein interaction networkDrug sensitivityGenomics of Drug SensitivityDrug targetsGene expression dataIGFR signaling pathwaysAssignment of high weightsBiomarker identificationExpression dataInteraction networkSensitivity predictionSignaling pathwaySignaling pathway inhibitorsReceptor pathwayTree ensemblesPathway inhibitorPathwayGenomeGenesGDSCNeighborhoods of influenceIdentificationSynthetic datasets
2018
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Inhibitory effects of cannabidiol on voltage-dependent sodium currents. Journal Of Biological Chemistry 2018, 293: 16546-16558. PMID: 30219789, PMCID: PMC6204917, DOI: 10.1074/jbc.ra118.004929.Peer-Reviewed Original ResearchConceptsAnticonvulsant effectsVoltage-dependent sodium currentsPotassium channelsSafety of cannabidiolNav channelsCentral nervous system targetsEffects of cannabidiolNervous system targetsVoltage-dependent currentsVoltage-gated potassium channelsVoltage-clamp electrophysiologyAntiepileptic effectClinical efficacyCase reportAlters membrane fluidityIPSC-neuronsTherapeutic mechanismSodium currentHEK-293 cellsReceptor pathwayΔ9-tetrahydrocannabinolInhibitory effectCannabidiolChannel excitabilitySodium channels
2017
MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics
Tilstam PV, Qi D, Leng L, Young L, Bucala R. MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics. Expert Opinion On Therapeutic Targets 2017, 21: 671-683. PMID: 28562118, PMCID: PMC6130320, DOI: 10.1080/14728222.2017.1336227.BooksConceptsMacrophage migration inhibitory factorMIF family membersCardiovascular diseaseFamily cytokinesTherapeutic opportunitiesIschemia-reperfusion injuryChemokine-like functionsMigration inhibitory factorNovel therapeutic opportunitiesPro-survival mediatorsFamily membersInflammatory pathogenesisMyocardial infarctionMyocardial ischemiaClinical studiesPleiotropic cytokineImmune systemInhibitory factorReceptor pathwayCytokinesDiseaseMIF-2Active investigationMIF familyClinical translation
2013
Apoptotic toxicity of destruxin B in human non-Hodgkin lymphoma cells
Chao PZ, Chin YP, Hsu IU, Liu CM, Yu YC, Leung TK, Lee YJ, Chen CH, Lin YF. Apoptotic toxicity of destruxin B in human non-Hodgkin lymphoma cells. Toxicology In Vitro 2013, 27: 1870-1876. PMID: 23751424, DOI: 10.1016/j.tiv.2013.05.016.Peer-Reviewed Original ResearchConceptsApoptosis-inducing factorDeath receptor pathwayDestruxin BNon-Hodgkin lymphoma cellsReceptor pathwayMitochondrial membrane potentialLymphoma cellsDeath domainExpression of tBidMitochondrial membranePotential anti-cancer activityCell growthApoptotic toxicityFungal toxinsCaspase-3Bcl-2Anti-cancer activityProtein expressionMembrane potentialApoptosisWestern blottingPathwayCellsExpressionTBid
2012
PHARMACODYNAMICS OF VORAPAXAR, A PLATELET PAR-1 ANTAGONIST, AND ITS INTERACTION WITH P2Y12 RECEPTOR PATHWAY IN THE TRACER TRIAL
Jennings L, Moliterno D, Storey R, Hord E, Kotha J, Becker R, Smyth S, Providencia L, Moccetti T, Valgimigli M, Dery J, Cornel J, Thomas G, Huber K, Chen E, Strony J, Rorick T, Tricoci P, Mahaffey K. PHARMACODYNAMICS OF VORAPAXAR, A PLATELET PAR-1 ANTAGONIST, AND ITS INTERACTION WITH P2Y12 RECEPTOR PATHWAY IN THE TRACER TRIAL. Journal Of The American College Of Cardiology 2012, 59: e351. DOI: 10.1016/s0735-1097(12)60352-0.Peer-Reviewed Original Research
2010
Human immune responses in cryptosporidiosis
Borad A, Ward H. Human immune responses in cryptosporidiosis. Future Microbiology 2010, 5: 507-519. PMID: 20210556, PMCID: PMC2856646, DOI: 10.2217/fmb.09.128.Peer-Reviewed Original ResearchConceptsHuman immune responseImmune responseToll-like receptor pathwayCell-mediated responsesMucosal antibody responsesAdaptive immune responsesPutative protective antigensInnate immune responseMannose-binding lectinAntibody responseT cellsIFN-gammaCryptosporidium infectionTherapeutic interventionsReceptor pathwayProtective antigenCryptosporidiosisCritical roleResponseAntimicrobial peptidesChemokinesCytokinesFurther knowledgeProstaglandinsInfection
2009
The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines.
Nowak D, Kawamata N, Niebuhr B, Nowak V, Mossner M, Nahar R, Thoennissen N, Iwanski G, Stocking C, Dugas M, Hofmann W, Müschen M, Koeffler P. The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines. Blood 2009, 114: 1284. DOI: 10.1182/blood.v114.22.1284.1284.Peer-Reviewed Original ResearchPre-B cell receptor signalingPre-B cell receptorWild-type PAX5Cell receptor signalingImmunoglobulin heavy locusCandidate genesFusion productsCell linesFunctional pre-B cell receptorB-cell-specific transcription factor Pax5Spleen tyrosine kinaseGlobal gene expression analysisReceptor signalingPleckstrin homology domainRetroviral expression constructsB-cell linkerGroup of genesTranscription factor Pax5Promoter binding sitesAdaptor protein 1Receptor pathwayGene expression analysisEmpty vector controlGene expression microarraysCommon genomic lesions
2007
ASC/PYCARD and Caspase-1 Regulate the IL-18/IFN-γ Axis during Anaplasma phagocytophilum Infection
Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. ASC/PYCARD and Caspase-1 Regulate the IL-18/IFN-γ Axis during Anaplasma phagocytophilum Infection. The Journal Of Immunology 2007, 179: 4783-4791. PMID: 17878377, DOI: 10.4049/jimmunol.179.7.4783.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAnaplasmaAnaplasmosisAnimalsApoptosis Regulatory ProteinsCalcium-Binding ProteinsCaspase 1Disease SusceptibilityEnzyme ActivationHL-60 CellsHumansInterferon-gammaInterleukin-18Killer Cells, NaturalMiceMice, Inbred C57BLMice, KnockoutPhagocytosisSignal TransductionTh1 CellsT-Lymphocytes, RegulatoryConceptsA. phagocytophilum infectionIFN-gamma productionCaspase-1Phagocytophilum infectionIFN-gammaA. phagocytophilumIFN-gamma levelsNOD-like receptor pathwayIL-18 secretionIFN-gamma-mediated controlCentral adaptor moleculeAnaplasma phagocytophilum infectionVitro restimulationIL-18Peripheral bloodControl animalsReceptor pathwayASC deficiencyInfectionObligate intracellular pathogensIntracellular pathogensAnaplasma phagocytophilumPhagocytophilumAdaptor moleculeCritical roleThe role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Podolsky DK, Louis E, Hafler DA, Rioux JD. The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes & Immunity 2007, 8: 387-397. PMID: 17538633, DOI: 10.1038/sj.gene.6364398.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCases of IBDRisk of IBDToll-like receptorsBowel diseaseIBD risk allelesUlcerative colitisCrohn's diseaseTLR4 pathwayIBD pathophysiologyIntestinal floraTLR pathwayTLR4 allelesHost defenseReceptor pathwayRisk allelesTLR genesDiseaseTLR4Modest effectHost/pathogen interactionsTIRAPAssociationReplication studyRisk
2006
The Nogo–Nogo Receptor Pathway Limits a Spectrum of Adult CNS Axonal Growth
Cafferty WB, Strittmatter SM. The Nogo–Nogo Receptor Pathway Limits a Spectrum of Adult CNS Axonal Growth. Journal Of Neuroscience 2006, 26: 12242-12250. PMID: 17122049, PMCID: PMC2848954, DOI: 10.1523/jneurosci.3827-06.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAxonsBehavior, AnimalCalcitonin Gene-Related PeptideCentral Nervous SystemFunctional LateralityGlial Fibrillary Acidic ProteinMiceMice, Inbred C57BLMice, KnockoutMyelin Basic ProteinMyelin ProteinsNogo ProteinsProtein Kinase CPsychomotor PerformancePyramidal TractsReceptors, PeptideSignal TransductionConceptsAxonal growthCST regenerationSpinal cord dorsal hemisectionCervical gray matterRole of NogoCorticospinal tract axonsNogo-66 receptorVivo pharmacological studiesFine motor skillsDorsal hemisectionAffected forelimbCST axonsLesion modelUnilateral pyramidotomyGray matterPharmacological studiesReceptor pathwayNogoConflicting resultsMiceMotor skillsAxonsDifferent tractsGenetic assessmentPyramidotomy
2005
Analysis of epidermal growth factor receptor (EGFR) pathway in oropharyngeal squamous cell cancer patients in vivo (OSCC)
Psyrri A, Yu Z, Haffty B, Sasaki C, Weinberger P, Camp R, Rimm D, Burtness B. Analysis of epidermal growth factor receptor (EGFR) pathway in oropharyngeal squamous cell cancer patients in vivo (OSCC). Journal Of Clinical Oncology 2005, 23: 5518-5518. DOI: 10.1200/jco.2005.23.16_suppl.5518.Peer-Reviewed Original ResearchSECRETION AND ABSORPTION BY COLONIC CRYPTS
Geibel JP. SECRETION AND ABSORPTION BY COLONIC CRYPTS. Annual Review Of Physiology 2005, 67: 471-490. PMID: 15709966, DOI: 10.1146/annurev.physiol.67.031103.153530.Peer-Reviewed Original Research
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