2025
Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery
Lynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, PMCID: PMC11972154, DOI: 10.1016/j.biomaterials.2025.123238.Peer-Reviewed Original ResearchAmniotic fluidProtein corona formationProtein coronaIntra-amniotic deliveryNP delivery systemPEGylated nanoparticlesSurface polyethylene glycolPoly(lactic-co-glycolic acidProtein corona compositionLung cells in vitroCorona formationPLA-PEG nanoparticlesNon-PEGylated nanoparticlesCells in vitroLevels of albuminFetal bowelFetal lungFetal organsNP biodistributionPoly(lactic-acidDense brush conformationCorona compositionPolyvinyl alcoholBiodistribution profileCellular association
2019
The viral protein corona directs viral pathogenesis and amyloid aggregation
Ezzat K, Pernemalm M, Pålsson S, Roberts T, Järver P, Dondalska A, Bestas B, Sobkowiak M, Levänen B, Sköld M, Thompson E, Saher O, Kari O, Lajunen T, Sverremark Ekström E, Nilsson C, Ishchenko Y, Malm T, Wood M, Power U, Masich S, Lindén A, Sandberg J, Lehtiö J, Spetz A, EL Andaloussi S. The viral protein corona directs viral pathogenesis and amyloid aggregation. Nature Communications 2019, 10: 2331. PMID: 31133680, PMCID: PMC6536551, DOI: 10.1038/s41467-019-10192-2.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBronchoalveolar Lavage FluidCell Line, TumorChlorocebus aethiopsDisease Models, AnimalFemaleHealthy VolunteersHerpes SimplexHerpesvirus 1, HumanHost-Pathogen InteractionsHumansMaleMiceMice, TransgenicPeptide FragmentsProtein AggregatesProtein CoronaRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanVero CellsConceptsProtein coronaRespiratory syncytial virusArtificial nanoparticlesProtein corona layerBiological fluidsDifferent biological fluidsImmune cell activationCorona layerSyncytial virusAmyloid plaquesObligate intracellular parasitesSimplex virusAmyloid β-peptideAnimal modelsViral-host interactionsHSV-1Cell activationViral pathogenesisAlzheimer's diseaseNanoparticlesType 1Viral infectivityIntracellular parasitesVirusDisease
2018
Chapter 3 Protein Corona: The Challenge at the Nanobiointerfaces
Zanganeh S, Ho J, Aieneravaie M, Erfanzadeh M, Spitler R. Chapter 3 Protein Corona: The Challenge at the Nanobiointerfaces. 2018, 91-104. DOI: 10.1016/b978-0-08-101925-2.00011-5.Peer-Reviewed Original Research
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