2025
Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery
Lynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, PMCID: PMC11972154, DOI: 10.1016/j.biomaterials.2025.123238.Peer-Reviewed Original ResearchAmniotic fluidProtein corona formationProtein coronaIntra-amniotic deliveryNP delivery systemPEGylated nanoparticlesSurface polyethylene glycolPoly(lactic-co-glycolic acidProtein corona compositionLung cells in vitroCorona formationPLA-PEG nanoparticlesNon-PEGylated nanoparticlesCells in vitroLevels of albuminFetal bowelFetal lungFetal organsNP biodistributionPoly(lactic-acidDense brush conformationCorona compositionPolyvinyl alcoholBiodistribution profileCellular association
2015
Poly(lactic-co-glycolide) polymer constructs cross-linked with human BMP-6 and VEGF protein significantly enhance rat mandible defect repair
Das A, Fishero B, Christophel J, Li C, Kohli N, Lin Y, Dighe A, Cui Q. Poly(lactic-co-glycolide) polymer constructs cross-linked with human BMP-6 and VEGF protein significantly enhance rat mandible defect repair. Cell And Tissue Research 2015, 364: 125-135. PMID: 26475719, DOI: 10.1007/s00441-015-2301-x.Peer-Reviewed Original ResearchConceptsDelivery of vascular endothelial growth factorVascular endothelial growth factorPoly(lactic-co-glycolic acidMesenchymal stem cellsThree-dimensional scaffoldsPoly(lactic-co-glycolideBMP-6Rat mesenchymal stem cellsThermal sinteringDelivery of mesenchymal stem cellsSignificant bone regenerationCombined deliveryVascular endothelial growth factor proteinCritical-size mandibular defectsPLAGA microspheresRecombinant human vascular endothelial growth factorBone repairSprague Dawley ratsEndothelial growth factorBone repair siteHuman vascular endothelial growth factorEnhancement of angiogenesisBone morphogenetic protein 6Bone regenerationDays in vitro
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