2025
Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions
Mao S, Song R, Jin S, Pang S, Jovanovic A, Zimmerman A, Li P, Wu X, Wendland M, Lin K, Chen W, Choksi S, Chen G, Holtzman M, Reiter J, Wan Y, Xuan Z, Xiang Y, Xu C, Upadhyayula S, Hess H, He L. Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions. Cell Reports 2025, 44: 115383. PMID: 40057957, DOI: 10.1016/j.celrep.2025.115383.Peer-Reviewed Original ResearchConceptsCSF productionChoroid plexusCerebrospinal fluidSonic hedgehog signalingWater channel AQP1Increased CSF productionHedgehog signalingChoroid plexus functionMotile ciliaMulticiliaSensory ciliaShh signalingNeonatal hydrocephalusSonic hedgehogCiliary lengthRegulate CSF productionSignal intensityCiliary ultrastructureChoroidEpithelial monolayersAQP1Developmental dynamicsCiliaATP1A2Plexus
2023
Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice
Kam C, Singh I, Gonzalez D, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi K, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell 2023, 186: 2345-2360.e16. PMID: 37167971, PMCID: PMC10225355, DOI: 10.1016/j.cell.2023.04.017.Peer-Reviewed Original ResearchConceptsAdult endothelial cellsNeonatal endothelial cellsEndothelial cellsVascular maturationAdult homeostasisOrgan growthAdult maintenanceHomeostasisLive miceVessel regressionFundamental mechanismsGlobal ablationLocal ablationMaturationNetwork perfusionVascular plexusBlood vesselsLongitudinal imagingVessel repairMaintenanceVascular architecturePlexusFunctional networksMiceMechanismThe choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
Robert S, Reeves B, Kiziltug E, Duy P, Karimy J, Mansuri M, Marlier A, Allington G, Greenberg A, DeSpenza T, Singh A, Zeng X, Mekbib K, Kundishora A, Nelson-Williams C, Hao L, Zhang J, Lam T, Wilson R, Butler W, Diluna M, Feinberg P, Schafer D, Movahedi K, Tannenbaum A, Koundal S, Chen X, Benveniste H, Limbrick D, Schiff S, Carter B, Gunel M, Simard J, Lifton R, Alper S, Delpire E, Kahle K. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 2023, 186: 764-785.e21. PMID: 36803604, PMCID: PMC10069664, DOI: 10.1016/j.cell.2023.01.017.Peer-Reviewed Original ResearchConceptsPost-infectious hydrocephalusTLR4-dependent immune responseBlood-cerebrospinal fluid barrierSmall molecule pharmacotherapyCell cross talkPharmacological immunomodulationCytokine stormNeuroimmune disordersBrain infectionDrug treatmentImmune responseAcquired hydrocephalusHydrocephalus modelChoroid plexusFluid barrierHydrocephalusEpithelial cellsCSFMulti-omics investigationsCross talkHypersecretionHemorrhagePharmacotherapyImmunomodulationPlexus
2022
Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine
Cotero V, Graf J, Miwa H, Hirschstein Z, Qanud K, Huerta TS, Tai N, Ding Y, Jimenez-Cowell K, Tomaio JN, Song W, Devarajan A, Tsaava T, Madhavan R, Wallace K, Loghin E, Morton C, Fan Y, Kao TJ, Akhtar K, Damaraju M, Barenboim L, Maietta T, Ashe J, Tracey KJ, Coleman TR, Di Carlo D, Shin D, Zanos S, Chavan SS, Herzog RI, Puleo C. Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine. Nature Biomedical Engineering 2022, 6: 683-705. PMID: 35361935, PMCID: PMC10127248, DOI: 10.1038/s41551-022-00870-w.Peer-Reviewed Original ResearchConceptsGlucose homeostasisGlucose toleranceNerve plexusAfferent autonomic nervesHyperinsulinemic euglycaemic clampNon-pharmacologic therapiesType 2 diabetesInsulin-resistant diabetesHepatic portal systemAutonomic nervesNerve pathwaysDiabetic miceFocused ultrasound stimulationPeripheral neuronsSensory projectionsIntestinal tissueMetabolic diseasesMulti-omics profilingPortal systemMetabolic tissuesGlucose availabilityDiabetesSelective activationPlexusUltrasound stimulation
2021
Fractal Dimension Analysis of OCTA Images of Diabetic Retinopathy Using Circular Mass-Radius Method.
Hashmi S, Lopez J, Chiu B, Sarrafpour S, Gupta A, Young J. Fractal Dimension Analysis of OCTA Images of Diabetic Retinopathy Using Circular Mass-Radius Method. Ophthalmic Surgery Lasers And Imaging Retina 2021, 52: 116-122. PMID: 34038685, DOI: 10.3928/23258160-20210302-01.Peer-Reviewed Original ResearchConceptsSevere nonproliferative DRNonproliferative DRDiabetic retinopathyProliferative DROCTA imagesSevere nonproliferative diabetic retinopathyNonproliferative diabetic retinopathyDeep capillary plexusProliferative diabetic retinopathyModerate nonproliferative DROptical coherence tomography angiography (OCTA) imagesMicrovascular dropoutTomography angiography imagesDiabetic eyesControl eyesRetrospective studyDeep plexusSuperficial plexusMicrovascular differencesCapillary plexusPlexusScansRetinopathySignificant differencesEyes
2019
Choroid Plexus Enlargement and Allostatic Load in Schizophrenia
Zhou Y, Huang J, Zhang P, Fan F, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Yuan Y, Yang F, Savransky A, Ryan M, Goldwaser E, Chiappelli J, Rowland L, Kochunov P, Tan Y, Hong L. Choroid Plexus Enlargement and Allostatic Load in Schizophrenia. Schizophrenia Bulletin 2019, 46: 722-731. PMID: 31603232, PMCID: PMC7147577, DOI: 10.1093/schbul/sbz100.Peer-Reviewed Original ResearchConceptsChoroid plexusHigher allostatic loadAllostatic loadSex-matched healthy controlsCentral nervous system abnormalitiesFirst-episode schizophrenia patientsChoroid plexus enlargementNervous system abnormalitiesTotal intracranial volumeHealthy controlsThalamus volumeLateral ventricleNeuroendocrine biomarkersSystem abnormalitiesAmygdala volumeSchizophrenia patientsBrain disordersInitial stabilizationIntracranial volumeStructural biomarkersPlexusBrain structuresPatientsSchizophreniaGroup differences
2018
9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus
Furey C, Antwi P, Duran D, Timberlake AT, Nelson-Williams C, Matouk CC, DiLuna ML, Günel M, Kahle KT. 9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus. Molecular Case Studies 2018, 4: a003145. PMID: 29895553, PMCID: PMC6169828, DOI: 10.1101/mcs.a003145.Peer-Reviewed Original ResearchConceptsDiffuse villous hyperplasiaVillous hyperplasiaChoroid plexusSyndromic hydrocephalusCerebrospinal fluid homeostasisSurgical managementPathological featuresHigh prevalenceHydrocephalus treatmentHydrocephalusDVHCPFluid homeostasisCSF productionHyperplasiaPlexusChromosome 9pCritical genesHypersecretionPatientsPathogenesisPrevalenceDisease
2017
A Rare Complication of a TAP Block Performed after Caesarean Delivery
Salaria ON, Kannan M, Kerner B, Goldman H. A Rare Complication of a TAP Block Performed after Caesarean Delivery. Case Reports In Anesthesiology 2017, 2017: 1072576. PMID: 29214081, PMCID: PMC5682055, DOI: 10.1155/2017/1072576.Peer-Reviewed Case Reports and Technical NotesTAP blockTransient femoral nerve palsyTransversus abdominis plane blockFemoral nerve palsyExcellent safety profileRegional anesthesia techniquesCaesarean deliveryNerve palsyCaesarean sectionPlane blockRare complicationMajor complicationsSacral plexusSafety profileAnesthesia techniquesComplicationsPalsyPatientsPlexusInflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine 2017, 23: 997-1003. PMID: 28692063, DOI: 10.1038/nm.4361.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAnimalsAntioxidantsBlotting, WesternBumetanideCerebral HemorrhageCerebral VentriclesCerebrospinal FluidChoroid PlexusDiureticsGene Knockdown TechniquesGene Knockout TechniquesHydrocephalusImmunoblottingImmunohistochemistryImmunoprecipitationInflammationNF-kappa BProlineProtein Serine-Threonine KinasesRatsRats, WistarSalicylanilidesSolute Carrier Family 12, Member 2SulfonamidesThiocarbamatesToll-Like Receptor 4
2013
Cervical ribs: identification on MRI and clinical relevance
Walden M, Adin M, Visagan R, Viertel V, Intrapiromkul J, Maluf F, Patel N, Alluwaimi F, Lin D, Yousem D. Cervical ribs: identification on MRI and clinical relevance. Clinical Imaging 2013, 37: 938-941. PMID: 23759210, DOI: 10.1016/j.clinimag.2013.01.005.Peer-Reviewed Original Research
2011
Eosinophilic Myenteric Ganglionitis
Chander B, Fiedler P, Jain D. Eosinophilic Myenteric Ganglionitis. Journal Of Clinical Gastroenterology 2011, 45: 314-316. PMID: 20921901, DOI: 10.1097/mcg.0b013e3181f5978a.Peer-Reviewed Original ResearchConceptsEosinophilic myenteric ganglionitisMyenteric ganglionitisAuerbach's plexusSigmoid colonFunctional bowel obstructionOnly significant findingBowel dysmotilityFecal disimpactionRecurrent obstipationBowel obstructionClinical improvementHartmann's procedureUnknown etiologyCase reportDisease entityMuscular layerGanglionitisResectionEosinophilsPlexusColonInfiltrationSignificant findingsDysmotilityObstipation
2009
Cannabinoid Hyperemesis Relieved by Compulsive Bathing
Chang Y, Windish D. Cannabinoid Hyperemesis Relieved by Compulsive Bathing. Mayo Clinic Proceedings 2009, 84: 76-78. PMID: 19121257, PMCID: PMC2664574, DOI: 10.4065/84.1.76.Peer-Reviewed Original ResearchConceptsCannabinoid hyperemesisLong-term marijuana useType 1 cannabinoid receptorInhibitory effectIntestinal nerve plexusesUnusual adverse effectMarijuana useCompulsive bathingGastrointestinal motilityNerve plexusClinical syndromeCannabinoid receptorsPatient needsHyperemesisHot showersAdverse effectsBathing behaviourThermoregulatory roleMarijuana usersVomitingEndocannabinoidsPlexusSyndromeReceptors
2008
Initial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele
Reiner E, Pollak JS, Henderson KJ, Weiss RM, White RI. Initial Experience with 3% Sodium Tetradecyl Sulfate Foam and Fibered Coils for Management of Adolescent Varicocele. Journal Of Vascular And Interventional Radiology 2008, 19: 207-210. PMID: 18341950, DOI: 10.1016/j.jvir.2007.08.013.Peer-Reviewed Original ResearchConceptsInternal spermatic veinSodium tetradecyl sulfate foamSTS foamAdolescent patientsPampiniform plexusSI jointLeft internal spermatic veinRight femoral veinResults of treatmentSurgical recurrenceScrotal discomfortTesticular atrophyCollateral vesselsPhysical examinationFemoral veinSpermatic veinSacroiliac jointAdolescent varicoceleFibered coilsPatientsInitial experienceVaricoceleAdolescent subjectsDeliberate passagePlexus
2000
Choroid plexus changes after temporal lobectomy.
Saluja S, Sato N, Kawamura Y, Coughlin W, Putman C, Spencer D, Sze G, Bronen R. Choroid plexus changes after temporal lobectomy. American Journal Of Neuroradiology 2000, 21: 1650-3. PMID: 11039344, PMCID: PMC8174865.Peer-Reviewed Original ResearchConceptsTemporal lobectomyChoroid plexusPostoperative changesResection siteNormal postoperative changesRecurrent brain tumorsContrast-enhanced T1-weighted imagesPresence of infectionContrast-enhanced MR imagingDegree of enhancementT1-weighted imagesChoroid plexus changesHippocampal sclerosisRecurrent tumorsIntractable epilepsyNodular patternPathologic changesPostoperative siteLobectomyBrain tumorsEnhancement patternSurgical manipulationPlexusMorphologic changesMR imaging
1996
Delayed radiation-induced bulbar palsy
Shapiro B, Rordorf G, Schwamm L, Preston D. Delayed radiation-induced bulbar palsy. Neurology 1996, 46: 1604-1606.. PMID: 8649557, DOI: 10.1212/wnl.46.6.1604.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBulbar Palsy, ProgressiveCachexiaCarcinomaCobalt RadioisotopesCranial Nerve InjuriesCranial NervesDeglutition DisordersDyspneaElectromyographyEnteral NutritionHumansMaleNasopharyngeal NeoplasmsNeck InjuriesNeck MusclesPneumonia, AspirationRadiation InjuriesRadioisotope TeletherapySpeech DisordersTime Factors
1995
The Blood-Retinal Barrier in Immune-Mediated Diseases of the Retina
Greenwood J, Bamforth S, Wang Y, Devine L. The Blood-Retinal Barrier in Immune-Mediated Diseases of the Retina. 1995, 315-326. DOI: 10.1007/978-1-4899-1054-7_31.Peer-Reviewed Original ResearchBlood-brain barrierBlood-retinal barrierBlood-CSF barrierCentral nervous systemTight junctionsBlood-tissue barriersFenestrated vasculatureCerebral parenchymaCerebral vasculatureChoroid plexusNervous systemEndothelial cellsChoroidal epitheliumExtracellular fluidDelicate homeostasisRetinaSystemic influencesBrainVasculatureCellular barriersPlexusNeuroretinaDiseaseBloodParenchyma
1992
Topographic mapping of the cutaneous microcirculation using two outputs of laser-Doppler flowmetry: Flux and the concentration of moving blood cells
Braverman I, Schechner J, Silverman D, Keh-Yen A. Topographic mapping of the cutaneous microcirculation using two outputs of laser-Doppler flowmetry: Flux and the concentration of moving blood cells. Microvascular Research 1992, 44: 33-48. PMID: 1640878, DOI: 10.1016/0026-2862(92)90100-4.Peer-Reviewed Original ResearchConceptsUpper plexusLaser Doppler flowmetryCutaneous microcirculationTrephine biopsyVascular unitAvascular zoneAscending arteriolesVascular patternMicrovascular areaPlexusBlood cellsUpper thirdFlexor forearmSerial sectionsLaser Doppler instrumentArteriolesForearmPeripheral partCMBCPhysiological studiesSubjectsCell outputBiopsyFlowmetryMicrocirculation
1989
Localization of angiotensin converting enzyme in the ciliary epithelium of the rat eye.
Strittmatter SM, Braas KM, Snyder SH. Localization of angiotensin converting enzyme in the ciliary epithelium of the rat eye. Investigative Ophthalmology & Visual Science 1989, 30: 2209-14. PMID: 2551838.Peer-Reviewed Original ResearchConceptsCiliary epitheliumRat eyesLocalization of angiotensinAnti-ACE antibodiesAqueous humor productionACE immunoreactivityACE inhibitorsPotent ACE inhibitorPosterior chamberChoroid plexusImmunocytochemical stainingMonoclonal antibodiesChoroidal epitheliumVentricular surfaceEpitheliumAngiotensinHumor productionEyesMajor siteACEAntibodiesLow levelsHigh levelsPlexusImmunoreactivity
1986
Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme.
Strittmatter SM, Lynch DR, Snyder SH. Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme. Brain Research 1986, 394: 207-15. PMID: 3021286, DOI: 10.1016/0165-3806(86)90096-9.Peer-Reviewed Original ResearchConceptsBasal gangliaAdult ratsChoroid plexusEnkephalin convertaseAdult levelsRat brain peptidasesExpression of ACEWeeks of ageBrain peptidasesStriatonigral systemAcid autoradiographyPerinatal periodPostnatal weekRat brainDifferential ontogenyPostnatal developmentPrenatal expressionMost neuropeptidesAngiotensinHigh concentrationsThalamusGangliaBirthPlexusRatsDifferential ontogeny of rat brain peptidases: Prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme
Strittmatter S, Lynch D, Snyder S. Differential ontogeny of rat brain peptidases: Prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme. Brain Research 1986, 29: 207-215. DOI: 10.1016/0165-3806(86)90096-9.Peer-Reviewed Original ResearchBasal gangliaAdult ratsChoroid plexusEnkephalin convertaseAdult levelsRat brain peptidasesExpression of ACEWeeks of ageBrain peptidasesStriatonigral systemAcid autoradiographyPerinatal periodPostnatal weekRat brainDifferential ontogenyPostnatal developmentPrenatal expressionMost neuropeptidesAngiotensinHigh concentrationsThalamusGangliaBirthPlexusRats
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply