2025
Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury
Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.Peer-Reviewed Original ResearchCalcium signalingCalcium channelsTherapeutic strategiesCalcium homeostasisFunction of calcium channelsDysregulated calcium signalingModulation of injuryTraumatic brain injuryBrain injuryLoss of calcium homeostasisBlast-related traumatic brain injuryDevelopment of neuroprotective interventionsIntracellular calcium dynamicsPlasma membrane stabilityExtracellular calciumBlast traumatic brain injuryPreclinical modelsTherapeutic outcomesNeuroprotective interventionsMembrane abnormalitiesPharmacological inhibitorsNeuronal somataExclusion criteriaCalcium dynamicsSecondary injury
2013
Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator
Villella VR, Esposito S, Bruscia EM, Vicinanza M, Cenci S, Guido S, Pettoello-Mantovani M, Carnuccio R, De Matteis MA, Luini A, Maiuri MC, Raia V, Kroemer G, Maiuri L. Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator. Cell Death & Differentiation 2013, 20: 1101-1115. PMID: 23686137, PMCID: PMC3705602, DOI: 10.1038/cdd.2013.46.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBeclin-1BronchiCell LineCell MembraneCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsHumansMembrane ProteinsMutationPhosphoric Monoester HydrolasesProteostasis Deficienciesrab5 GTP-Binding ProteinsReceptors, TransferrinSequestosome-1 ProteinConceptsCFTR proteinBronchial epithelial cellsCFTR surface expressionSmall GTPase Rab5Cystic fibrosis transmembrane conductance regulatorFibrosis transmembrane conductance regulatorWild-type CFTRFunctional CFTR proteinSQSTM1/p62Transmembrane conductance regulatorPositive feed-forward loopPlasma membrane stabilityFeed-forward loopEpithelial cellsProteostasis regulationProtein traffickingProteostasis networkGTPase Rab5Rab5 effectorProteostasis regulatorsConformational diseasesCystic fibrosis transmembrane conductance regulator (CFTR) potentiatorRecycling defectsSQSTM1 accumulationUnexpected link
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