2025
Lipid Dynamics at Membrane Contact Sites
Reinisch K, De Camilli P, Melia T. Lipid Dynamics at Membrane Contact Sites. Annual Review Of Biochemistry 2025, 94: 479-502. PMID: 40067957, DOI: 10.1146/annurev-biochem-083024-122821.Peer-Reviewed Original ResearchConceptsContact sitesOrganelle contact sitesMembrane contact sitesIntegral membrane proteinsLipid transfer proteinsVesicular traffickingEndoplasmic reticulumLipid transferMembrane proteinsLipid movementOrganellesLipid transportTransfer proteinCellular membranesProteinBilayer asymmetryLipid dynamicsShedding new lightLipidMembranePhysiological mechanismsEukaryotesSitesReticulumTraffickingPhysiologic mechanisms underlying polycystic kidney disease
Boletta A, Caplan M. Physiologic mechanisms underlying polycystic kidney disease. Physiological Reviews 2025, 105: 1553-1607. PMID: 39938884, PMCID: PMC12174308, DOI: 10.1152/physrev.00018.2024.Peer-Reviewed Original ResearchPrimary ciliaPolycystic kidney diseaseTrafficking of proteinsHuman ciliopathiesExtracellular signalsMultiple genesKidney diseaseProtein productionMolecular basisCell biologyMonogenic disordersCyst formationGenesRenal epithelial cellsProteinCiliaBiochemical informationApical surfaceEpithelial cellsFunctional expressionPhysiological propertiesWealth of informationPhysiological mechanismsCellsFibrocystin
2023
Identification of an adipose tissue-resident pro-preadipocyte population
Chen M, Kim S, Li L, Chattopadhyay S, Rando T, Feldman B. Identification of an adipose tissue-resident pro-preadipocyte population. Cell Reports 2023, 42: 112440. PMID: 37119138, PMCID: PMC10370484, DOI: 10.1016/j.celrep.2023.112440.Peer-Reviewed Original ResearchConceptsDeconvolution of cell typesSingle-cell RNA sequencingCell typesScRNA-seqRNA sequencingRegulate adipogenesisPopulation of cellsHeterogeneous population of cellsExpression profilesStromal vascular fractionAdipocyte lineagePreadipocyte populationPathwayProgenitor cellsTherapeutic opportunitiesCellsPhysiological mechanismsAdipose tissueHeterogeneous populationLineagesStem cellsFunctional propertiesPreadipocytesProgenitorsSequenceCell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling
Feng X, Sun R, Lee M, Chen X, Guo S, Geng H, Müschen M, Choi J, Pereira J. Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. ELife 2023, 12: e83533. PMID: 36912771, PMCID: PMC10042536, DOI: 10.7554/elife.83533.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsLymphotoxin beta receptorLeukemic cellsBeta receptorsLeukemic cell growthBone marrow microenvironmentStem cellsTransplant recipientsAML cellsMyeloblastic leukemiaMouse modelBone marrowLeukemia growthLymphotoxin α1β2Marrow microenvironmentPharmacological disruptionLymphopoiesisReceptorsHematopoietic outputMolecular mechanismsErythropoiesisDNA damage response pathwayCell growthCellsPhysiological mechanisms
2021
Associations between fecal cortisol and biparental care in a pair‐living primate
Corley M, Perea‐Rodriguez J, Valeggia C, Fernandez‐Duque E. Associations between fecal cortisol and biparental care in a pair‐living primate. American Journal Of Biological Anthropology 2021, 176: 295-307. PMID: 34272723, PMCID: PMC8429222, DOI: 10.1002/ajpa.24368.Peer-Reviewed Original Research
2020
Physical Object Representations for Perception and Cognition
Yildirim I, Siegel M, Tenenbaum J. Physical Object Representations for Perception and Cognition. 2020, 399-410. DOI: 10.7551/mitpress/11442.003.0046.Peer-Reviewed Original ResearchCognitive neuroscienceComputational models of cognitionModels of cognitionSocial neuroscienceBiological underpinningsPsychological realityObject representationsCognitionNeuroscienceFoundational referencesScientific ethicsChart new directionsScientific habitsRewardMemoryDecision makingMindfulnessUnderpinningsFoundational topicsPhysiological mechanismsNervous systemNew directionsEditingEthicsLanguage
2019
In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird
Lattin CR, Merullo DP, Riters LV, Carson RE. In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird. Scientific Reports 2019, 9: 10407. PMID: 31320692, PMCID: PMC6639298, DOI: 10.1038/s41598-019-46845-x.Peer-Reviewed Original ResearchConceptsWild houseMore time feedingWild birdsReceptor bindingIndividual variationBirdsUnderstanding of linksCaptivityPhysiological mechanismsLong-term stressorsTime feedingStress resilienceCaptivity stressPhysiological variationsNeuroendocrine phenotypeBindingPhysiologyBehavioral responsesSubset of individualsStressorsWildlifePhenotypeImportant implicationsIndividual's physiological variationsStressAssociations Between Maternal Experiences of Discrimination and Biomarkers of Toxic Stress in School-Aged Children
Condon EM, Holland ML, Slade A, Redeker NS, Mayes LC, Sadler LS. Associations Between Maternal Experiences of Discrimination and Biomarkers of Toxic Stress in School-Aged Children. Maternal And Child Health Journal 2019, 23: 1147-1151. PMID: 31222595, PMCID: PMC6660374, DOI: 10.1007/s10995-019-02779-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlack or African AmericanBlood PressureC-Reactive ProteinChildChild, PreschoolConnecticutCross-Sectional StudiesFemaleHair AnalysisHispanic or LatinoHumansInterleukin-1betaInterleukin-6Interleukin-8MaleMothersRacismSalivaSocioeconomic FactorsStress, PsychologicalTumor Necrosis Factor-alphaConceptsSalivary interleukin-6 levelsInterleukin-6 levelsMaternal experienceCross-sectional studyMaternal-child dyadsPoor health outcomesEthnic health inequitiesToxic stressSchool-Aged ChildrenChild healthNoninvasive biomarkersImmune pathwaysChild biomarkersHealth outcomesHealth inequitiesBiomarkersChildrenIndirect exposureLow-income neighborhoodsVicarious racismBiological mechanismsAdditional researchMothersExperiences of discriminationPhysiological mechanisms
2018
Enhancing memory with stress: Progress, challenges, and opportunities
Goldfarb EV. Enhancing memory with stress: Progress, challenges, and opportunities. Brain And Cognition 2018, 133: 94-105. PMID: 30553573, PMCID: PMC9972486, DOI: 10.1016/j.bandc.2018.11.009.Peer-Reviewed Original ResearchConceptsLong-term memoryDeclarative memoryHippocampal-dependent memory processesMemory-related brain regionsHippocampus-dependent memoryMemory processesMemory functionRodent researchMemoryBrain regionsCentral stress responseFuture researchAcute stressPeripheral stress responsesStress effectsModulatory factorsRodent studiesPositive effectStress responseHuman studiesTranslational gapHumansResearchPhysiological mechanismsRodentsMetabolic regulation and glucose sensitivity of cortical radial glial cells
Rash BG, Micali N, Huttner AJ, Morozov YM, Horvath TL, Rakic P. Metabolic regulation and glucose sensitivity of cortical radial glial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 10142-10147. PMID: 30224493, PMCID: PMC6176632, DOI: 10.1073/pnas.1808066115.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRGC fibersCortical radial glial cellsEmbryonic cortical slicesGestational obesityCerebral cortexCortical slicesMetabolic disturbancesCortical neurogenesisMetabolic supportBrain disordersAcute lossMitochondrial transportBrain developmentIntracellular CaPotential mechanismsHyperglycemiaMitochondrial functionGlucose sensitivityMiceStem cellsPrimary stem cellsPhysiological mechanismsCells
2015
Endocrine‐Autonomic Linkages
Sladek C, Michelini L, Stachenfeld N, Stern J, Urban J. Endocrine‐Autonomic Linkages. Comprehensive Physiology 2015, 5: 1281-1323. DOI: 10.1002/j.2040-4603.2015.tb00634.x.Peer-Reviewed Original ResearchPreganglionic autonomic neuronsHypothalamic paraventricular nucleusAutonomic nervous systemAutonomic neuronsParaventricular nucleusNeuroendocrine neuronsNeuroendocrine actionsPeripheral hormonesParasympathetic outflowGonadal steroidsBlood pressureMaintenance of homeostasisNeuronal populationsElectrolyte balanceNervous systemNeuroendocrine systemAutonomic mechanismsEnergy homeostasisAutonomic responsesAutonomous systemsNeuronsBody temperatureHomeostasisPhysiological mechanismsEndocrine‐Autonomic Linkages
Sladek CD, Michelini LC, Stachenfeld NS, Stern JE, Urban JH. Endocrine‐Autonomic Linkages. 2015, 5: 1281-1323. PMID: 26140719, DOI: 10.1002/cphy.c140028.Peer-Reviewed Original ResearchConceptsHypothalamic paraventricular nucleusAutonomic nervous systemParasympathetic outflowPeripheral hormonesAutonomic neuronsBlood pressureNeuroendocrine actionsGonadal steroidsParaventricular nucleusMaintenance of homeostasisElectrolyte balanceNeuroendocrine neuronsNervous systemNeuronal populationsAutonomic responsesNeuroendocrine systemAutonomic mechanismsEnergy homeostasisNeuroendocrineBody temperatureNeuronsAutonomic systemPhysiological mechanismsHomeostasisPhysiological parametersPhysiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism
Burke MV, Small DM. Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism. Physiology & Behavior 2015, 152: 381-388. PMID: 26048305, PMCID: PMC4661139, DOI: 10.1016/j.physbeh.2015.05.036.Peer-Reviewed Original ResearchConceptsNon-nutritive sweetenersNNS consumptionCognitive processesSugar-sweetened beverage consumptionNegative health outcomesMetabolic hormone secretionPotential biological mechanismsHormone secretionSSB intakeBody weightGut microbiotaSweet taste receptorBeverage consumptionHealth outcomesNNS useCentral mechanismsTaste receptorsBiological mechanismsMetabolic functionsPhysiological mechanismsMetabolismIntakeSecretionReceptors
2014
Gender differences in the impact of stressful life events on changes in body mass index
Udo T, Grilo CM, McKee SA. Gender differences in the impact of stressful life events on changes in body mass index. Preventive Medicine 2014, 69: 49-53. PMID: 25204986, PMCID: PMC4312235, DOI: 10.1016/j.ypmed.2014.08.036.Peer-Reviewed Original ResearchConceptsBody mass indexStressful life eventsWave 2 interviewsWeight gainMass indexLife eventsNational Epidemiologic SurveyGreater weight gainWave 1Epidemiologic SurveyRelated conditionsFemale-specific effectWomenWave 2 surveyPositive associationEffects of stressGreater increaseDeath of familyRepresentative sampleMenGender differencesPhysiological mechanismsSpontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk
Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ, Greco V. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Nature Communications 2014, 5: 3543. PMID: 24667544, PMCID: PMC3974217, DOI: 10.1038/ncomms4543.Peer-Reviewed Original ResearchConceptsTumor regressionRetinoic acidSquamous cell carcinomaSpontaneous tumor regressionMouse model systemCell carcinomaMalignant tumorsTherapeutic strategiesCutaneous keratoacanthomasKeratoacanthomaPhysiological mechanismsTumor growthHuman keratoacanthomaTumorsHair follicle regenerationCancer biologyFollicle regenerationRegressionDifferentiation programWntCarcinomaPathway
2013
Decreased food pleasure and disrupted satiety signals in chronic low back pain
Geha P, deAraujo I, Green B, Small DM. Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain 2013, 155: 712-722. PMID: 24384160, DOI: 10.1016/j.pain.2013.12.027.Peer-Reviewed Original ResearchConceptsChronic low back painCLBP patientsLow back painHealthy controlsBack painSugary drinksFat calorie intakeHedonic perceptionSatiety signalsCalorie intakePatientsIntake testFood pleasureFunctional brainAd libitumPotential mechanismsPainObesityIntakeStructural alterationsPhysiological mechanismsHedonic ratingsAlterationsDrinksSensory evaluationA Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency
Tellez LA, Medina S, Han W, Ferreira JG, Licona-Limón P, Ren X, Lam TT, Schwartz GJ, de Araujo IE. A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency. Science 2013, 341: 800-802. PMID: 23950538, DOI: 10.1126/science.1239275.Peer-Reviewed Original ResearchConceptsDopamine deficiencyFed miceDietary fatExcess dietary fatBrain dopaminergic functionHigh fat intakeHigh-fat exposureGastrointestinal dysfunctionIntragastric feedingOral intakeDopaminergic functionDopamine releaseExcessive intakeIntakeMiceDeficiencyOleoylethanolamineLipid messengersPhysiological mechanismsFatMotivation deficitsLipid signalingReward sensitivityObesityDysfunctionNO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. Journal Of Clinical Investigation 2013, 123: 1718-1731. PMID: 23454748, PMCID: PMC3613910, DOI: 10.1172/jci65112.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalAnimalsCell EnlargementCells, CulturedCoronary VesselsEndothelium, VascularHeart VentriclesMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, TransgenicMultiprotein ComplexesMyocytes, CardiacNeovascularization, PhysiologicNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthasePlacenta Growth FactorPregnancy ProteinsProteinsProteolysisProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyRGS ProteinsSignal TransductionTOR Serine-Threonine KinasesConceptsCardiomyocyte growthAkt/mTORC1 signalingNovel NO-dependent mechanismProteasomal degradationCoordination of angiogenesisMTORC1 signalingConditional overexpressionMurine cardiac tissueG proteinsTransgenic expressionAkt/Physiological mechanismsMyocyte growthVessel growthGrowth factorTransgenic miceHypertrophic responseAngiogenesisKnockout miceMyocardial hypertrophyExpressionGrowthCardiac hypertrophyNOS inhibitor L-NAMEInduction
2012
Postoperative apnea, respiratory strategies, and pathogenesis mechanisms: a review
Kaye AD, Hollon MM, Vadivelu N, Kodumudi G, Kaye RJ, Bueno FR, Baluch AR. Postoperative apnea, respiratory strategies, and pathogenesis mechanisms: a review. Journal Of Anesthesia 2012, 27: 423-432. PMID: 23179739, DOI: 10.1007/s00540-012-1517-0.Peer-Reviewed Original ResearchConceptsPostoperative apneaPostoperative patientsPostoperative pulmonary complicationsTerms of mortalityPostoperative ventilationPulmonary complicationsHospital staySupportive careVentilation supportAirway maintenanceCerebral cortexAdequate oxygenationAortic bodiesDifferential diagnosisApneaPathogenesis mechanismsOxygenationPatientsRespiratory strategiesVentilationAdditional oxygenationPhysiological mechanismsCauseExtubationMorbidity
2010
Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume
Leiserson WM, Forbush B, Keshishian H. Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume. Glia 2010, 59: 320-332. PMID: 21125654, PMCID: PMC3005002, DOI: 10.1002/glia.21103.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBlood-Nerve BarrierCells, CulturedDrosophilaDrosophila ProteinsExtracellular SpaceHumansIn Vitro TechniquesLarvaMicroscopy, Electron, TransmissionModels, BiologicalMutationNeural ConductionNeurogliaNeuronsPeripheral NervesProtein Serine-Threonine KinasesSymportersTwo-Hybrid System TechniquesConceptsHuman NKCC1Yeast two hybrid assaysExtracellular solute compositionLarvae mutantDrosophila gliaNcc69Osmotic homeostasisExtracellular volumeMolecular mechanismsNervous systemOrthologsExtracellular solutesPhysiological mechanismsBlood-brain barrierBlood-nerve barrierSimilar roleAccumulation of fluidAction potential conductionGlial cellsPeripheral neuropathyNKCC1Serious health threatDetectable impactBlood barrierGlia
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