2025
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.Peer-Reviewed Original ResearchConceptsAcute kidney injuryTubular epithelial cellsKidney injuryTubular cellsCases of acute kidney injuryImmune-mediated processPersistence of inflammationBiphasic immune responseChronic kidney diseaseCell deathTubular cell injuryLymphocyte subsetsTubular repairCell cycle arrestOutflow obstructionTEC differentiationPreclinical findingsLymphocytic infiltrationProinflammatory macrophagesKidney diseaseModulate inflammationImmune responseActivated macrophagesMetabolic reprogrammingTubular casts
2023
Intra-Aortic Balloon Pump Exacerbates Left Ventricular Outflow Tract Obstruction in a Patient With Takotsubo and Hypertrophic Cardiomyopathy
Griffin M, Odanovic N, McNamara R, Altin S, Balan S, Thompson J, Young L. Intra-Aortic Balloon Pump Exacerbates Left Ventricular Outflow Tract Obstruction in a Patient With Takotsubo and Hypertrophic Cardiomyopathy. Case 2023, 7: 502-507. PMID: 38197115, PMCID: PMC10772928, DOI: 10.1016/j.case.2023.07.003.Peer-Reviewed Original ResearchCongenitally Corrected Transposition of the Great Arteries: Fetal Diagnosis, Associations, and Postnatal Outcome: A Fetal Heart Society Research Collaborative Study
Cohen J, Arya B, Caplan R, Donofrio M, Ferdman D, Harrington J, Ho D, Hogan W, Hornberger L, Jhaveri S, Killen S, Lindblade C, Michelfelder E, Moon‐Grady A, Patel S, Quezada E, Ronai C, Mejia A, Schidlow D, Stiver C, Thakur V, Srivastava S. Congenitally Corrected Transposition of the Great Arteries: Fetal Diagnosis, Associations, and Postnatal Outcome: A Fetal Heart Society Research Collaborative Study. Journal Of The American Heart Association 2023, 12: e029706. PMID: 37259984, PMCID: PMC10381988, DOI: 10.1161/jaha.122.029706.Peer-Reviewed Original ResearchMeSH KeywordsArrhythmias, CardiacAtrioventricular BlockCongenitally Corrected Transposition of the Great ArteriesFemaleFetal DeathFetal HeartFollow-Up StudiesHeart Defects, CongenitalHumansInfantPregnancyPrenatal DiagnosisPulmonary AtresiaRetrospective StudiesTransposition of Great VesselsTricuspid Valve InsufficiencyConceptsDeath/transplantSerial fetal echocardiogramsTricuspid regurgitationAortic obstructionPulmonary atresiaFetal deathGreat arteriesFetal echocardiogramFetal diagnosisAssociated cardiac defectsAssociated cardiac lesionsPulmonary outflow obstructionMedian gestational ageMild tricuspid regurgitationFetal tricuspid regurgitationBiventricular repairExtracardiac anomaliesOutflow obstructionSerial echocardiogramsCardiac lesionsClinical outcomesFetal factorsGestational ageUnivariable analysisAtrioventricular block
2022
Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond
Morelli C, Ingrasciotta G, Jacoby D, Masri A, Olivotto I. Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond. European Journal Of Internal Medicine 2022, 102: 1-7. PMID: 35534374, DOI: 10.1016/j.ejim.2022.04.020.Peer-Reviewed Original ResearchConceptsHeart failureCardiovascular medicineVentricular outflow obstructionHeart muscle diseaseDegenerative neuromuscular diseaseSpecific disease mechanismsCardiovascular deathOutflow obstructionSystolic functionRandomized trialsUnderlying pathophysiologyCardiac patientsOmecamtiv mecarbilHypertrophic cardiomyopathyFunctional capacityNeuromuscular diseaseMuscle diseaseAvailable evidenceContractile proteinsSkeletal muscleTranslational researchPromising targetDiseaseDisease mechanismsFailure
2021
Chronic opioid use is associated with obstructive and spastic disorders in the esophagus
Sanchez MJ, Olivier S, Gediklioglu F, Almeida M, Gaeta M, Nigro M, de la Rosa R, Nguyen M, Lalehzari M, Regala F, Njei B, Deng Y, Ciarleglio M, Masoud A. Chronic opioid use is associated with obstructive and spastic disorders in the esophagus. Neurogastroenterology & Motility 2021, 34: e14233. PMID: 34532898, PMCID: PMC11152085, DOI: 10.1111/nmo.14233.Peer-Reviewed Original ResearchConceptsEsophagogastric junction outflow obstructionDistal esophageal spasmNon-opioid usersAchalasia type IIIIneffective esophageal motilityHigh-resolution manometryDistal latencyOpioid useEsophageal motilityOpioid usersMME groupChronic opioid effectsChronic opioid useDose of opioidsEsophageal motility disordersType IIIElectronic medical recordsManometric abnormalitiesSpastic disordersOpioid effectsOutflow obstructionEsophageal spasmMotility disordersRetrospective studyManometric results
2020
Budd-Chiari Syndrome An Uncommon Cause of Chronic Liver Disease that Cannot Be Missed
Haque LYK, Lim JK. Budd-Chiari Syndrome An Uncommon Cause of Chronic Liver Disease that Cannot Be Missed. Clinics In Liver Disease 2020, 24: 453-481. PMID: 32620283, DOI: 10.1016/j.cld.2020.04.012.BooksConceptsBudd-Chiari syndromeLiver diseaseHepatic venous outflow obstructionPrimary Budd-Chiari syndromeDevelopment of cirrhosisVenous outflow obstructionChronic liver diseaseLife-threatening diagnosisVariable clinical presentationPortal hypertensionProthrombotic stateVenous obstructionLifelong anticoagulationMost patientsOutflow obstructionUncommon causeClinical presentationRare causeRisk factorsHepatocellular carcinomaHigh indexPatientsDiseaseSyndromeObstructionIliac Venous Stenting for Outflow Obstruction Does Not Significantly Change the Quality of Life of Patients With Severe Chronic Venous Insufficiency
Shiferson A, Aboian E, Shih M, Pu Q, Jacob T, Rhee R. Iliac Venous Stenting for Outflow Obstruction Does Not Significantly Change the Quality of Life of Patients With Severe Chronic Venous Insufficiency. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2020, 8: 494. PMID: 33371984, DOI: 10.1016/j.jvsv.2020.02.004.Peer-Reviewed Original Research
2019
Iliac venous stenting for outflow obstruction does not significantly change the quality of life of patients with severe chronic venous insufficiency
Shiferson A, Aboian E, Shih M, Pu Q, Jacob T, Rhee RY. Iliac venous stenting for outflow obstruction does not significantly change the quality of life of patients with severe chronic venous insufficiency. JRSM Cardiovascular Disease 2019, 8: 2048004019890968. PMID: 31839939, PMCID: PMC6893555, DOI: 10.1177/2048004019890968.Peer-Reviewed Original ResearchIliac venous stentingChronic venous insufficiencyQuality of lifeAdvanced chronic venous insufficiencyChronic venous insufficiency patientsOutflow obstructionVenous stentingGroup patientsVenous insufficiencyIntravascular ultrasonographyStented groupChronic Venous Insufficiency QualitySevere chronic venous insufficiencyCIVIQ-20 questionnaireCIVIQ-20 scoresNon-stented groupConservative medical managementCase-control studyIliac venous systemQuestionnaire one yearCEAP 5CIVIQ-20Outflow stenosisPersistent painIliac stenting
2017
A systematic review on management of nutcracker syndrome
Velasquez CA, Saeyeldin A, Zafar MA, Brownstein AJ, Erben Y. A systematic review on management of nutcracker syndrome. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2017, 6: 271-278. PMID: 29292117, DOI: 10.1016/j.jvsv.2017.11.005.Peer-Reviewed Original ResearchConceptsLeft renal veinManagement of NCSNutcracker syndromePaucity of dataSystematic reviewLRV transpositionEndovascular techniquesStent implantationTreatment of NCSMeta-Analyses (PRISMA) statement standardsUncommon disease processVenous outflow obstructionOpen surgical interventionBest treatment modalityBest treatment strategyOpen surgical approachLong-term patencyPreferred Reporting ItemsAnatomic compressionRenal autotransplantationOutflow obstructionEndovascular approachRenal veinSurgical interventionRare entity
2016
The Spectrum of Histologic Findings in Hepatic Outflow Obstruction
Gonzalez RS, Gilger MA, Huh WJ, Washington MK. The Spectrum of Histologic Findings in Hepatic Outflow Obstruction. Archives Of Pathology & Laboratory Medicine 2016, 141: 98-103. PMID: 27681331, PMCID: PMC6420777, DOI: 10.5858/arpa.2015-0388-oa.Peer-Reviewed Original ResearchConceptsHepatic outflow obstructionPortal tract changesCardiac hepatopathyBudd-Chiari syndromeOutflow obstructionHistologic findingsBudd-ChiariSinusoidal fibrosisSinusoidal dilationTract changesCentral veinHepatic venous outflow obstructionVenous outflow obstructionBile ductular reactionDistinctive histologic findingsHepatocyte dropoutDifferent pathophysiologyPrior diagnosisChronic inflammationCentrilobular necrosisDuctular reactionMorphologic findingsUndiagnosed patientsChronic natureHepatopathySuperior Mesenteric Arterial Flow Pattern is Associated with Major Adverse Events in Adults with Fontan Circulation
Mori M, Shioda K, Elder RW, Pernetz MA, Rodriguez FH, Rangosch A, Kogon BE, Book WM. Superior Mesenteric Arterial Flow Pattern is Associated with Major Adverse Events in Adults with Fontan Circulation. Pediatric Cardiology 2016, 37: 1013-1021. PMID: 27033246, DOI: 10.1007/s00246-016-1382-y.Peer-Reviewed Original ResearchConceptsVelocity time integralAdult Fontan patientsEnd-diastolic velocitySystolic/diastolic ratioMajor adverse eventsAdverse eventsMesenteric arterial flowFontan patientsFontan circulationResistive indexDiastolic ratioArterial flowSuperior mesenteric arterial flowDiastolic velocity-time integralAdult Fontan populationSystolic velocity time integralVenous outflow obstructionCox regression analysisPediatric Fontan patientsKaplan-Meyer analysisNon-event groupArterial flow patternsFontan populationAdult patientsOutflow obstruction
2003
Surgery for Third Ventricular Tumors
Johnson R, Baehring J, Piepmeier J. Surgery for Third Ventricular Tumors. Neurosurgery Quarterly 2003, 13: 207-225. DOI: 10.1097/00013414-200309000-00006.Peer-Reviewed Original ResearchPineal region tumorsThird ventricular regionThird ventricleVentricular regionSubependymal giant cell astrocytomaVisual field impairmentThird ventricular tumorsGiant cell astrocytomaGoal of surgeryMultiple surgical approachesAnterior third ventricleCentral nervous systemCognitive memory deficitsAdjuvant chemotherapyInterhemispheric transcallosalParinaud's syndromeField impairmentNeurologic morbidityOutflow obstructionObstructive hydrocephalusClinical presentationSuprasellar tumorsVentricle resultsVentricular tumorsSurgical approach
1991
Tricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome
Hornberger L, Sahn D, Kleinman C, Copel J, Reed K. Tricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome. Journal Of The American College Of Cardiology 1991, 17: 167-173. PMID: 1987222, DOI: 10.1016/0735-1097(91)90722-l.Peer-Reviewed Original ResearchConceptsTricuspid valve diseasePulmonary atresiaPulmonary stenosisEbstein's anomalyClinical courseValve diseaseUnguarded tricuspid valve orificeSevere congestive heart failureAssociated cardiac lesionsBenign neonatal courseComplex heart lesionsPulmonary outflow obstructionRight atrial dilationRight-sided cardiomegalySignificant tricuspid insufficiencySignificant tricuspid regurgitationCongestive heart failurePulmonary artery flowTricuspid valve dysplasiaTricuspid valve orificeTricuspid tissueNeonatal courseOutflow obstructionTricuspid insufficiencyTricuspid regurgitation
1986
Accessory Mitral Valve Tissue Causing Left Ventricular Outflow Obstruction (Two-Dimensional Echocardiographic Diagnosis and Surgical Approach)
Ascuitto R, Ross-Ascuitto N, Kopf G, Kleinman C, Talner N. Accessory Mitral Valve Tissue Causing Left Ventricular Outflow Obstruction (Two-Dimensional Echocardiographic Diagnosis and Surgical Approach). The Annals Of Thoracic Surgery 1986, 42: 581-584. PMID: 3778009, DOI: 10.1016/s0003-4975(10)60590-5.Peer-Reviewed Original ResearchConceptsAccessory mitral valve tissueVentricular outflow tract obstructionVentricular outflow obstructionOutflow tract obstructionTwo-dimensional echocardiographyMitral valve tissueNative mitral valveDoppler flow analysisTract obstructionOutflow obstructionPreoperative evaluationRare causeMitral valveIntraoperative techniquesValve tissueAccessory tissuesObstructionTissueEchocardiographySurgery
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