2025
Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse
Hanke-Gogokhia C, Zapadka T, Finkelstein S, Arshavsky V, Demb J. Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse. Advances In Experimental Medicine And Biology 2025, 1468: 325-330. PMID: 39930217, DOI: 10.1007/978-3-031-76550-6_54.Peer-Reviewed Original ResearchConceptsSynaptic vesicle exocytosisSynaptic vesicle recyclingPhotoreceptor ribbon synapseVesicle exocytosisVesicle recyclingVesicle cycleVesicle releaseRibbon synapseProtein synthesisProperties of synaptic transmissionMolecular componentsMouse rodsSynaptic terminalsRod cellsProteinVesiclesRod photoreceptorsDim lightSynaptic transmissionInner segmentsCellsExocytosisEndocytosisOuter segmentsEnergy production
2001
Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC‐2 Cl− channel disruption
Bösl M, Stein V, Hübner C, Zdebik A, Jordt S, Mukhopadhyay A, Davidoff M, Holstein A, Jentsch T. Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC‐2 Cl− channel disruption. The EMBO Journal 2001, 20: 1289-1299. PMID: 11250895, PMCID: PMC145530, DOI: 10.1093/emboj/20.6.1289.Peer-Reviewed Original ResearchConceptsClC-2Abnormal Sertoli cellsBlood-retina barrierGerm cellsRetinal pigment epitheliumCl- channelsSevere degenerationMale infertilityPigment epitheliumMale germ cellsClC-2 Cl(-) channelOvert abnormalitiesSeminiferous tubulesNormal outer segmentsSertoli cellsOuter segmentsRetinaCell typesDeathMassive deathCellsPrimary spermatocytesHuman diseasesTubulesCLC Cl(-) channels
2000
Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors
Yarovinsky T, Rickman D, Diamond R, Taub R, Hageman G, Rickman C. Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. Brain Research 2000, 77: 95-103. PMID: 10814835, DOI: 10.1016/s0169-328x(00)00045-0.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphatasePRL-1 genePRL-1Regenerating Liver-1Tyrosine phosphataseSingle mRNA speciesAmino acid sequencePRL-1 mRNAPrimate cone photoreceptorsPhotoreceptor cell functionImmediate early genesUnique transcriptsCone photoreceptor cellsCone photoreceptorsCDNA clonesMRNA speciesAcid sequenceAffinity-purified antibodiesOuter segmentsEarly genesSouthern blotGenesHigh abundanceChromosome 6qPhosphatase activity
1983
cGMP and EGTA increase the light-sensitive current of retinal rods
Lipton S. cGMP and EGTA increase the light-sensitive current of retinal rods. Brain Research 1983, 265: 41-48. PMID: 6303507, DOI: 10.1016/0006-8993(83)91331-8.Peer-Reviewed Original Research
1982
[34] Proteolysis of rhodopsin
Pober J. [34] Proteolysis of rhodopsin. Methods In Enzymology 1982, 81: 236-239. PMID: 7047990, DOI: 10.1016/s0076-6879(82)81036-7.Peer-Reviewed Original ResearchConceptsLight-activated enzymesOrganization of rhodopsinMembrane proteinsPolypeptide sequenceHigh-resolution mappingConformational changesLimited proteolysisBovine rhodopsinCleavage siteRod outer segmentsRhodopsinProteolysisRegion of interactionDisk membranesResolution mappingSpecific sitesOuter segmentsValuable probe
1977
Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins.
Lipton S, Rasmussen H, Dowling J. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins. Journal Of General Physiology 1977, 70: 771-791. PMID: 201724, PMCID: PMC2228513, DOI: 10.1085/jgp.70.6.771.Peer-Reviewed Original ResearchConceptsCombination of drugsIsolated toad retinaCyclic nucleotide levelsCombination of IBMXResponse amplitudeDrug levelsReceptor sensitivityLong-term exposureReceptor saturationIntracellular cGMPMM IBMXRetinaControl RingerSimilar alterationsElectrical activityCGMPRod photoreceptorsV-log IATPase pumpRod activitySuperfusionDark adaptationOuter segmentsSensitivity recoveryCyclic nucleotides
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