2025
Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell
Zapadka T, Tran N, Demb J. Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell. The Journal Of Physiology 2025 PMID: 39985791, DOI: 10.1113/jp286414.Peer-Reviewed Original ResearchOptic nerve crushRetinal ganglion cellsOptic nerveGanglion cellsSynaptic inputsVoltage-gated sodium channel currentsRetinal ganglion cell typesVoltage-gatedRetinal ganglion cell survivalChelation of intracellular calciumResting membrane potentialOptic nerve injuryVoltage-gated currentsAxonal injurySodium channel currentsRetinal ganglion cell axonsRGC typesAlpha retinal ganglion cellsAxon initial segmentIntracellular calciumRate of survivalNerve injuryElectrophysiological propertiesNerve crushIntrinsic excitability
2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2018
Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury
Sergeeva E, Espinosa-Garcia C, Atif F, Pardue M, Stein D. Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury. Experimental Neurology 2018, 306: 138-148. PMID: 29729249, PMCID: PMC6021019, DOI: 10.1016/j.expneurol.2018.05.005.Peer-Reviewed Original ResearchConceptsOptic nerve crush injuryNeurosteroid allopregnanoloneIntact eyeTherapeutic potential of allopregnanoloneUnilateral optic nerve injuryOptic nerve injuryPost-injury days 3Enhancement of visual responsesSpatial frequency thresholdsNerve crush injuryIpsilateral visual cortexHyper-activityExperience-dependent plasticityVisual cortexModulation of plasticityGABA inhibitionNerve injuryAdult miceSide ipsilateralAllopregnanoloneDay 3Crush injuryCrushed nervesTreated animalsTherapeutic potential
2014
Nogo limits neural plasticity and recovery from injury
Schwab ME, Strittmatter SM. Nogo limits neural plasticity and recovery from injury. Current Opinion In Neurobiology 2014, 27: 53-60. PMID: 24632308, PMCID: PMC4122629, DOI: 10.1016/j.conb.2014.02.011.Peer-Reviewed Original ResearchConceptsNeural repairCentral nervous system injuryOptic nerve injurySpinal cord traumaNervous system injuryExperience-dependent plasticityIschemic strokeNerve injuryCord traumaFunctional recoveryMultiple sclerosisSystem injuryReceptor NgR1Neural plasticityPhysiologic roleAxonal anatomyInjuryAdult mammalsMultiple studiesNogoNgR1Molecular studiesRepairSclerosisAntagonist
1998
Restricted expression of the neuronal intermediate filament protein plasticin during zebrafish development
Canger A, Passini M, Asch W, Leake D, Zafonte B, Glasgow E, Schechter N. Restricted expression of the neuronal intermediate filament protein plasticin during zebrafish development. The Journal Of Comparative Neurology 1998, 399: 561-572. PMID: 9741483, DOI: 10.1002/(sici)1096-9861(19981005)399:4<561::aid-cne8>3.0.co;2-#.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesAxonsBlotting, WesternCytoskeletonDNA, ComplementaryEye ProteinsFemaleGene Expression Regulation, DevelopmentalGoldfishIntermediate Filament ProteinsLarvaMaleMembrane GlycoproteinsNerve Tissue ProteinsNeurofilament ProteinsNeuronsOptic NervePeripherinsRNA, MessengerZebrafishZebrafish ProteinsConceptsRetinal ganglion cellsNervous systemOptic nerve injuryPeripheral nervous systemNerve injuryGanglion neuronsProjection neuronsRGC axonsReticulospinal neuronsGanglion cellsCranial nervesProject axonsAxon regenerationEarly neuronsVisual pathwayLong axonsAxonal outgrowthNeuronsNeuronal developmentAxon tractsRohon-BeardAxonsEarly stagesAxon outgrowthRestricted expressionCloning of Zebrafish Neurofilament cDNAs for Plasticin and Gefiltin: Increased mRNA Expression in Ganglion Cells After Optic Nerve Injury
Asch W, Leake D, Canger A, Passini M, Argenton F, Schechter N. Cloning of Zebrafish Neurofilament cDNAs for Plasticin and Gefiltin: Increased mRNA Expression in Ganglion Cells After Optic Nerve Injury. Journal Of Neurochemistry 1998, 71: 20-32. PMID: 9648847, DOI: 10.1046/j.1471-4159.1998.71010020.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCloning, MolecularDNA, ComplementaryEye ProteinsFish ProteinsGene Expression RegulationGoldfishIntermediate Filament ProteinsMolecular Sequence DataNerve CrushNerve RegenerationNerve Tissue ProteinsNeurofilament ProteinsOptic NerveOptic Nerve InjuriesRetinal Ganglion CellsRNA, MessengerSequence Homology, Amino AcidVisual PathwaysZebrafishConceptsNeuronal intermediate filament proteinOptic nerve crushOptic nerve injuryGoldfish visual pathwayIntermediate filament proteinsOptic axon regenerationIntermediate filament compositionNerve crushNerve injuryUnoperated eyesGanglion cellsGefiltinFilament proteinsAxon regenerationRetinal growthBaseline levelsVisual pathwayAxonal growthSoluble factorsMRNA expressionMRNA levels
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