2025
Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation
Carbone F, Després J, Ioannidis J, Neeland I, Garruti G, Busetto L, Liberale L, Ministrini S, Vilahur G, Schindler T, Macedo M, Di Ciaula A, Krawczyk M, Geier A, Baffy G, Faienza M, Farella I, Santoro N, Frühbeck G, Yárnoz‐Esquiroz P, Gómez‐Ambrosi J, Chávez‐Manzanera E, Vázquez‐Velázquez V, Oppert J, Kiortsis D, Sbraccia P, Zoccali C, Portincasa P, Montecucco F. Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation. European Journal Of Clinical Investigation 2025, e70059. PMID: 40371883, DOI: 10.1111/eci.70059.Peer-Reviewed Original ResearchBody mass indexObesity-related cardiometabolic riskStigma associated with obesityCommunity-level interventionsOptimal care deliveryEffective management of obesityConsensus statementGlobal public health challengeAssociated with chronic diseasesClinical investigationDrivers of obesityPublic health challengePublic health narrativesImprove prevention strategiesCare deliveryManagement of obesityObesity trendsTailored interventionsCollaborative effortsHealth systemCardiometabolic riskGlobal health systemObesity epidemicHealth narrativesChronic diseasesDietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Wing A, Jeffery E, Church C, Goodell J, Saavedra-Peña R, Saha M, Holtrup B, Voisin M, Alavi N, Floody M, Wang Z, Zapadka T, Garabedian M, Varshney R, Rudolph M, Rodeheffer M. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Reports 2025, 44: 115527. PMID: 40208790, PMCID: PMC12073628, DOI: 10.1016/j.celrep.2025.115527.Peer-Reviewed Original ResearchAdipocyte precursor cellsDietary fatPlasma monounsaturated fatty acidsAssociated with human obesityHuman adipocyte precursor cellsMonounsaturated fatty acidsDietary fat compositionDietary screeningFatty acidsDietary fatty acidsHuman obesityAdipose expansionMetabolic healthObesity epidemicAkt2 signalingLXR activationPrecursor cellsAdipose biologyOleic acidHyperplasiaObesityAdipocyte hyperplasiaDietary oleic acidPhysiological regulationAdipogenesis
2024
Estimating the lives that could be saved by expanded access to weight-loss drugs
Pandey A, Ye Y, Wells C, Singer B, Galvani A. Estimating the lives that could be saved by expanded access to weight-loss drugs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2412872121. PMID: 39405358, PMCID: PMC11513960, DOI: 10.1073/pnas.2412872121.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Body mass index categoriesObesity prevalence dataGlucagon-like peptide-1 receptor agonistsHazard ratio of mortalityRatio of mortalityPublic health impactWeight loss drugsInsurance coverage issuesGastric inhibitory polypeptideHealthcare accessType 2 diabetesUnited StatesPublic health crisisObesity epidemicReceptor agonistsIndex categoriesHazard ratioPrevalence dataInhibitory polypeptidePeptide-1Health impactsNovel treatmentObesityHealth crisisThe interactions between energy homeostasis and neurovascular plasticity
Chen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. The interactions between energy homeostasis and neurovascular plasticity. Nature Reviews Endocrinology 2024, 20: 749-759. PMID: 39054359, DOI: 10.1038/s41574-024-01021-8.Peer-Reviewed Original ResearchWestern dietLifestyle interventionNeurovascular systemCurrent obesity epidemicEnergy homeostasisStable body weightLocal neuronal networksRegulate energy balanceNeuronal networksFood intakeObesity epidemicSedentary lifestylePharmacological interventionsNeurovascular plasticityOverall healthNutritional milieuWeight lossLong-term needsCardiovascular systemBody weightEnergy expenditureAdverse effectsBrain centresLifestyleBrain vasculatureUnited States Long-Term Trends in Adult BMI (1959–2018): Unraveling the Roots of the Obesity Epidemic
Banas J, Cook A, Raygoza-Cortez K, Davila D, Irwin M, Ferrucci L, Humphries D. United States Long-Term Trends in Adult BMI (1959–2018): Unraveling the Roots of the Obesity Epidemic. International Journal Of Environmental Research And Public Health 2024, 21: 73. PMID: 38248537, PMCID: PMC10815706, DOI: 10.3390/ijerph21010073.Peer-Reviewed Original ResearchNational Health Examination SurveyExamination SurveyObesity epidemicBody mass index (BMI) trendsOngoing obesity epidemicCritical public health challengeNutrition Examination SurveyHealth Examination SurveyRates of obesityPublic health challengePopulation-level interventionsBMI growth rateEffective population-level interventionsRace/ethnicityAverage BMIAdult BMINational HealthBMI trendsHigh school educationWhite adultsAge groupsBlack adultsHealth challengesBMIRacial disparitiesA Narrative Review of Public Health Interventions for Childhood Obesity
Heerman W, Kenney E, Block J, Fiechtner L, McMahon E, Kruse L, Sharifi M, Edmondson E, Virudachalam S. A Narrative Review of Public Health Interventions for Childhood Obesity. Current Obesity Reports 2024, 13: 87-97. PMID: 38172483, DOI: 10.1007/s13679-023-00550-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPublic health interventionsChildhood obesityHealth interventionsNutrition Assistance ProgramNarrative reviewChild weight statusChildhood obesity ratesScientific evidenceChildhood obesity epidemicCommunity-wide interventionsFederal nutrition assistance programsBest scientific evidenceEarly careCommunity-based programsObesity interventionsWeight statusHigh prevalencePhysical activityObesity epidemicCurrent evidenceObesityObesity ratesPopulation levelHealthy nutritionIntervention
2023
Screening, Diagnosis, and Staging of Non-Alcoholic Fatty Liver Disease (NAFLD): Application of Society Guidelines to Clinical Practice
Ilagan-Ying Y, Banini B, Do A, Lam R, Lim J. Screening, Diagnosis, and Staging of Non-Alcoholic Fatty Liver Disease (NAFLD): Application of Society Guidelines to Clinical Practice. Current Gastroenterology Reports 2023, 25: 213-224. PMID: 37768417, DOI: 10.1007/s11894-023-00883-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNon-alcoholic fatty liver diseaseNon-invasive testsFatty liver diseaseLiver diseaseCommon chronic liver diseaseNonalcoholic fatty liver diseaseCurrent expert guidelinesHigh-risk patientsChronic liver diseaseSteatotic liver diseaseClinical practice implicationsHepatic decompensationLiver biopsySociety guidelinesSpecialty referralsNovel therapiesExpert guidelinesLiver cancerDisease awarenessObesity epidemicSerum indicesClinical practiceScreening toolDiseaseDiagnosis
2022
Revisiting the Principles of Preservation in an Era of Pandemic Obesity
Langford JT, DiRito JR, Doilicho N, Chickering GR, Stern DA, Ouyang X, Mehal W, Tietjen GT. Revisiting the Principles of Preservation in an Era of Pandemic Obesity. Frontiers In Immunology 2022, 13: 830992. PMID: 35432296, PMCID: PMC9011385, DOI: 10.3389/fimmu.2022.830992.Peer-Reviewed Original ResearchConceptsDeceased donorsOrgan preservationDonor populationIschemia-reperfusion injuryCurrent obesity epidemicHealthy donor populationPandemic obesityObese donorsReperfusion injuryMetabolic dysfunctionObesity epidemicObesitySignificant declineOrgansDonorsPopulationCurrent practiceDysfunctionTransplantInjury
2020
Metabolic Syndrome in Child and Adolescent Psychiatry
Kim H, Wilson C, Van Deusen T, Millard H, Qayyum Z, Parke S. Metabolic Syndrome in Child and Adolescent Psychiatry. Psychiatric Annals 2020, 50: 326-333. DOI: 10.3928/00485713-20200630-01.Peer-Reviewed Original ResearchMetabolic syndromeHigh-density lipoprotein cholesterolCardiometabolic risk factorsElevated blood pressureManagement of obesitySecond-generation antipsychoticsPediatric MetSCentral obesityElevated triglyceridesLipoprotein cholesterolBlood pressureMetabolic derangementsPediatric populationRisk factorsClinical utilityObesity epidemicPsychiatric disordersEarly identificationStandardized guidelinesClear consensusObesityAdolescent psychiatrySyndromeMetSControversial topicA Longitudinal Study of Life Trauma, Chronic Stress and Body Mass Index on Weight Gain over a 2-Year Period
Fogelman N, Magin Z, Hart R, Sinha R. A Longitudinal Study of Life Trauma, Chronic Stress and Body Mass Index on Weight Gain over a 2-Year Period. Behavioral Medicine 2020, 48: 162-170. PMID: 32552603, PMCID: PMC7744435, DOI: 10.1080/08964289.2020.1780192.Peer-Reviewed Original ResearchConceptsBody mass indexCumulative Adversity InterviewLife traumaWeight gainChronic stressMass indexObesity-related health outcomesTrauma copingGreater weight gainLean individualsTrauma eventsObesity epidemicLongitudinal effectsHealth outcomesCurrent findingsLongitudinal studyTraumaVulnerable individualsObesitySignificant increaseTwo-year periodIndividualsCopingHigh levelsOverweightDeterminants of accurate visual perception of child anthropometric phenotype among ethnically diverse preschool parents in the United States
Messiah S, Weerakoon S, Atem F, Schulte M, Lebron C, Kambali S, Mathew M, Chang C, Natale R. Determinants of accurate visual perception of child anthropometric phenotype among ethnically diverse preschool parents in the United States. Health & Social Care In The Community 2020, 28: 2095-2104. PMID: 32510693, DOI: 10.1111/hsc.13020.Peer-Reviewed Original ResearchConceptsChild weight statusWeight statusBMI percentileParental perceptions of child weight statusPerceptions of child weight statusAnthropometric phenotypesHigher obesity prevalenceChild BMI percentileChildhood obesity epidemicAssociated with parental perceptionsCountry of birthNon-Hispanic parentsMexican caregiversMultivariate linear regressionCaregiver perceptionsObesity prevalenceHeight/weight measurementsUnhealthy weightHealthy weightUnhealthy BMIChi-square analysisObesity epidemicCaregiversChild sociodemographicsParents' perceptionsRegulating food craving: From mechanisms to interventions
Sun W, Kober H. Regulating food craving: From mechanisms to interventions. Physiology & Behavior 2020, 222: 112878. PMID: 32298667, PMCID: PMC7321886, DOI: 10.1016/j.physbeh.2020.112878.Peer-Reviewed Original ResearchConceptsCognitive strategiesCue reactivityNeural mechanismsCue-induced cravingUnderlying neural mechanismsToxic food environmentSubsequent food choiceFood cravingsCommon experienceCravingFood choicesStrong desireWeight outcomesFuture directionsCausal effectClinical perspectiveImportant lineInterventionTaskFood environmentCaloric consumptionPromising effectsObesity epidemicIndividualsExperienceMeeting ACR Dose Guidelines for CT Lung Cancer Screening in an Overweight and Obese Population
Peng R, Mardakhaev E, Shmukler A, Levsky J, Haramati L. Meeting ACR Dose Guidelines for CT Lung Cancer Screening in an Overweight and Obese Population. Academic Radiology 2020, 28: 381-386. PMID: 32284173, DOI: 10.1016/j.acra.2020.02.009.Peer-Reviewed Original ResearchConceptsBody mass indexLung cancer screeningBMI classificationDose guidelinesObese patientsDose metricsObese populationCancer screeningLung cancerCT lung cancer screeningRadiation doseMedian effective doseLow radiation doseMass indexStudy populationAmerican CollegeObesity epidemicDose requirementsEffective doseClinical programsPatientsDoseWomenSignificant differencesCTDIvol
2019
Gaps in provider lifestyle counseling and its adherence among obese adults with prediabetes and diabetes in the United States
Valero-Elizondo J, Aneni EC, Osondu CU, Grandhi GR, Virani SS, Nasir K. Gaps in provider lifestyle counseling and its adherence among obese adults with prediabetes and diabetes in the United States. Preventive Medicine 2019, 129: 105815. PMID: 31454663, DOI: 10.1016/j.ypmed.2019.105815.Peer-Reviewed Original ResearchConceptsLifestyle counselingObese adultsHealthcare providersManagement of obesityPrevalence of diabetesWeight loss programUS adult populationLevels of obesityLifestyle modificationDiabetes statusObese patientsSevere obesityLoss programMild obesityCardiovascular diseasePhysical activityObesity epidemicObesityDiabetesMetabolic diseasesAdult populationHealthy lifestyleCounselingPatientsAdultsSemiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis
Srikumar T, Siegel E, Gu Y, Balagurunathan Y, Garcia A, Chen Y, Zhou J, Zhao X, Gillies R, Clark W, Gamenthaler A, Choi J, Shibata D. Semiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis. Journal Of Surgical Research 2019, 237: 12-21. PMID: 30694786, PMCID: PMC7771581, DOI: 10.1016/j.jss.2018.11.027.Peer-Reviewed Original ResearchConceptsVisceral fat areaSubcutaneous fat areaTotal fat areaFat areaTomography scan analysisAbdominal adiposityIntraclass correlationL4-L5 intervertebral levelAverage body mass indexSubcutaneous fat ratioBody mass indexMedian ageRectal adenocarcinomaRisk stratificationMass indexIntervertebral levelObesity epidemicRadiologic methodsAdipose tissueSemiautomated measureAdiposityFat ratioHuman pathophysiologyImaging suiteSemiautomated method
2018
Positive views of aging reduce risk of developing later-life obesity
Levy BR, Slade MD. Positive views of aging reduce risk of developing later-life obesity. Preventive Medicine Reports 2018, 13: 196-198. PMID: 30705805, PMCID: PMC6348756, DOI: 10.1016/j.pmedr.2018.12.012.Peer-Reviewed Original ResearchOlder personsMore health-promoting behaviorsPositive SPAPrevalence of obesityLater life obesityHealth-promoting behaviorsPublic health effortsObesity epidemicRepresentative HealthObesityAge groupsNew casesPsychosocial determinantsRelevant covariatesOlder adultsLater lifeNegative SPASPA scoresRetirement StudySPA measuresScoresSpAPersonsAverage scoreParticipantsObesity as a Disease: The Obesity Society 2018 Position Statement
Jastreboff AM, Kotz CM, Kahan S, Kelly AS, Heymsfield SB. Obesity as a Disease: The Obesity Society 2018 Position Statement. Obesity 2018, 27: 7-9. PMID: 30569641, DOI: 10.1002/oby.22378.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDefined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State
Li C, Navarrete J, Liang-Guallpa J, Lu C, Funderburk S, Chang R, Liberles S, Olson D, Krashes M. Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State. Cell Metabolism 2018, 29: 681-694.e5. PMID: 30472090, PMCID: PMC6402975, DOI: 10.1016/j.cmet.2018.10.016.Peer-Reviewed Original ResearchConceptsParaventricular hypothalamusCorticotropin-releasing hormoneGlucagon-like peptide 1 receptorBody weight maintenancePeptide 1 receptorMelanocortin-4 receptorHypothalamic populationsEffective therapyWeight maintenanceFiber photometryAppetite regulationObesity epidemicMelanocortin-4Physiological response propertiesNeuronsFeeding behaviorParaventricularImmunohistochemistryTherapyLiraglutideDifferential responseHypothalamusObesityThe Obesity Epidemic
Mazer L, Morton J. The Obesity Epidemic. 2018, 81-92. DOI: 10.1007/978-3-319-71282-6_7.Peer-Reviewed Original ResearchPressing public health challengesDecreased life expectancyPublic health challengeSignificant health implicationsObese patientsKidney diseaseWorldwide epidemicCardiovascular diseaseObesity epidemicGreater health costsHealth challengesObesityPreventative effortsDiseaseLife expectancyHealth costsHealth implicationsPotential determinantsEpidemicPatientsDiabetesOsteoarthritisCancerLiverFood Cues and Obesity: Overpowering Hormones and Energy Balance Regulation
Belfort-DeAguiar R, Seo D. Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation. Current Obesity Reports 2018, 7: 122-129. PMID: 29619632, PMCID: PMC5959777, DOI: 10.1007/s13679-018-0303-1.BooksConceptsEnergy balance regulationFood cuesObesity epidemicBalance regulationTreatment of obesityDevelopment of obesityPoor treatment outcomesFood cue exposureFood cue reactivityPurpose of ReviewInModern obesogenic environmentFood cue responsesObese individualsWeight managementTreatment outcomesFood intakeCue-elicited responsesPsychosocial interventionsObesityConventional treatmentObesogenic environmentCue exposurePhysiology of feedingCue reactivityHormone
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