2025
Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury
Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.Peer-Reviewed Original ResearchCalcium signalingCalcium channelsTherapeutic strategiesCalcium homeostasisFunction of calcium channelsDysregulated calcium signalingModulation of injuryTraumatic brain injuryBrain injuryLoss of calcium homeostasisBlast-related traumatic brain injuryDevelopment of neuroprotective interventionsIntracellular calcium dynamicsPlasma membrane stabilityExtracellular calciumBlast traumatic brain injuryPreclinical modelsTherapeutic outcomesNeuroprotective interventionsMembrane abnormalitiesPharmacological inhibitorsNeuronal somataExclusion criteriaCalcium dynamicsSecondary injury
2022
A Systematic Review and Meta-Analysis of the Effectiveness of Neuroprotectants for Paclitaxel-Induced Peripheral Neuropathy
Leen A, Yap D, Teo C, Tan B, Molassiotis A, Ishiguro H, Fan S, Sundar R, Soon Y, Bandla A. A Systematic Review and Meta-Analysis of the Effectiveness of Neuroprotectants for Paclitaxel-Induced Peripheral Neuropathy. Frontiers In Oncology 2022, 11: 763229. PMID: 35070969, PMCID: PMC8766304, DOI: 10.3389/fonc.2021.763229.Peer-Reviewed Original ResearchPaclitaxel-induced peripheral neuropathyPeripheral neuropathyTreatment arm compared to controlsMeta-analysisPooled resultsNeuroprotective interventionsSide effects of paclitaxelEffects of paclitaxelDisabling side effectsEffect of neuroprotectionNon-pharmacological interventionsNon-pharmacological trialsRelevant controlled trialsNon-pharmacological approachesRandom-effects modelEffective prevention strategiesBiomedical Literature DatabasePrimary outcomePharmacological trialsModerate heterogeneityPrevention strategiesPharmacological interventionsSystematic reviewLiterature databasesIntervention
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