2025
CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis
Kostiuk V, Kabir R, Akbari R, Rushing A, González D, Kim A, Kim A, Zenisek D, Khokha M. CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis. Genesis 2025, 63: e70009. PMID: 40008628, PMCID: PMC11867209, DOI: 10.1002/dvg.70009.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseCACNA1GLow-voltage-activated calcium channelsExpression of Cacna1gCalcium channelsPatient cohortCardiac functionLR patterningHeterotaxyLR organizerChannel familyCACNA1SHeart diseaseLeft-rightG expressionXenopus tropicalisAbnormal expressionProcess of cilia formationCardiac loopingMultiple organsSignaling cascadesLR asymmetryPatientsT-typeEmbryonic developmentThe evolving understanding of systemic mechanisms in organ-specific IgA nephropathy: a focus on gut-kidney crosstalk
Wang X, Zhou X, Qiao X, Falchi M, Liu J, Zhang H. The evolving understanding of systemic mechanisms in organ-specific IgA nephropathy: a focus on gut-kidney crosstalk. Theranostics 2025, 15: 656-681. PMID: 39744688, PMCID: PMC11671385, DOI: 10.7150/thno.104631.Peer-Reviewed Original ResearchConceptsGut-kidney crosstalkExploration of gut microbiotaGut microbiotaKidney diseaseMechanism of IgANIntestinal microbiomeSignaling pathwayIgA nephropathyInter-organ crosstalkEfficient therapeutic strategiesPrognosis of patientsProgression of IgANElaborate mechanismsTherapeutic strategiesIgAN pathogenesisIgANCrosstalkMicrobiomeMicrobiotaMultiple organsKidneyProbioticsNephropathyDiseaseMechanism
2024
Implementing Entrustable Professional Activities in Pediatric Fellowships: Facilitating the Process.
Langhan M, Boyer D, Hsu D, Moffatt M, Pitts S, Atlas M, Aye T, Chess P, Curran M, Czaja A, Dammann C, Fussell J, George R, Herman B, High P, James S, Kamin D, Karnik R, Kesselheim J, Lopez M, Mahan J, McFadden V, McGann K, Mehta J, Rama J, Robinson B, Sauer C, Stafford D, Turner D, Weiss P, Yussman S, Schwartz A, Mink R. Implementing Entrustable Professional Activities in Pediatric Fellowships: Facilitating the Process. 2024, 153 PMID: 38757175, DOI: 10.1542/peds.2023-065024.Peer-Reviewed Original ResearchEntrustable professional activitiesPediatric fellowshipImplementation of entrustable professional activitiesFellowship program directorsImplementing entrustable professional activitiesFacilitators to implementationFacilitators of implementationResponse rateOutcome dataMultiple organsEPA-based assessmentNonusersAmerican Board of PediatricsPediatric subspecialtiesPerceived barriersSubspecialty physiciansPotential facilitatorsProgram directorsPediatricAmerican BoardAssessment formAssessment toolPediatric fellowsFPDTotal-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council
Slart R, Bengel F, Akincioglu C, Bourque J, Chen W, Dweck M, Hacker M, Malhotra S, Miller E, Pelletier-Galarneau M, Packard R, Schindler T, Weinberg R, Saraste A, Slomka P. Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266858. PMID: 38388512, DOI: 10.2967/jnumed.123.266858.Peer-Reviewed Original ResearchLong axial fieldAxial fieldCardiovascular diseaseLow-dose examinationsWhole-body coveragePET/CT systemField of cardiovascular diseaseCardiac physiologyAnatomic coveragePET/CT applicationsMultiple organsVascular structuresCardiovascular systemTracer kinetic modelAcquisition timeSimultaneous assessmentSystem sensitivityImage qualityDisease
2023
Use of Antipseudomonal Antibiotics is Not Associated With Lower Rates of Postoperative Drainage Procedures or More Favorable Culture Profiles in Children With Complicated Appendicitis
Cramm S, Graham D, Feng C, Allukian M, Blakely M, Chandler N, Cowles R, Kunisaki S, Lipskar A, Russell R, Santore M, Campbell B, Commander S, DeFazio J, Dukleska K, Echols J, Esparaz J, Gerall C, Griggs C, Hanna D, He K, Keane O, McLean S, Pace E, Scholz S, Sferra S, Tracy E, Zhang L, Rangel S, Network O. Use of Antipseudomonal Antibiotics is Not Associated With Lower Rates of Postoperative Drainage Procedures or More Favorable Culture Profiles in Children With Complicated Appendicitis. Annals Of Surgery 2023, 279: 1070-1076. PMID: 37970676, DOI: 10.1097/sla.0000000000006152.Peer-Reviewed Original ResearchConceptsComplicated appendicitisAntipseudomonal antibioticsDrainage proceduresPostoperative drainageSupplemental chart reviewRetrospective cohort studyAssociated with lower ratesMeasures of disease severityCompared to treatmentAntibiotic regimensNSQIP-Pediatric dataAntipseudomonal activityAntibiotic utilizationChart reviewCohort studyMulticenter dataAppendicitisCulture positivityDisease severityMultiple organsAntibioticsMixed-effects regressionPatientsLow rateCulture dataEndothelial Dysfunction in Cardiorenal Conditions: Implications of Endothelial Glucocorticoid Receptor-Wnt Signaling
Akhter M, Goodwin J. Endothelial Dysfunction in Cardiorenal Conditions: Implications of Endothelial Glucocorticoid Receptor-Wnt Signaling. International Journal Of Molecular Sciences 2023, 24: 14261. PMID: 37762564, PMCID: PMC10531724, DOI: 10.3390/ijms241814261.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorEndothelial dysfunctionVascular inflammationEndothelial cellsEndothelial glucocorticoid receptorAnti-inflammatory effectsFatty acid oxidation pathwayDifferent pathological conditionsSuppression of WntRenal diseaseInflammatory cascadeVascular toneNovel therapiesMultiple organsBlood fluidityEndothelial integrityPlatelet aggregationInnermost liningVessel permeabilityBlood vesselsPathological conditionsWnt pathwayInflammationDysfunctionDevastating diseaseLoss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice
Srivastava S, Goodwin J. Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice. American Journal Of Physiology. Renal Physiology 2023, 325: f519-f526. PMID: 37589053, PMCID: PMC10639025, DOI: 10.1152/ajprenal.00105.2023.Peer-Reviewed Original ResearchConceptsEndothelial glucocorticoid receptorGlucocorticoid receptorOrgan fibrosisMouse modelMultiple organsSpontaneous type 2 diabetesDb/db miceDiabetic kidney fibrosisReceptor-mediated upregulationUse of metforminDiabetic renal fibrosisType 2 diabetesMechanisms of fibrosisGenetic mouse modelsUpregulation of WntRenal fibrosisSevere fibrosisDb miceIL-6Key cytokineKidney fibrosisDisease processFibrosisFibrotic conditionsWnt inhibitorsMultimodality pictorial review of IgG4-related disease in the abdomen and pelvis
Czerniak S, Rao A, Mathur M. Multimodality pictorial review of IgG4-related disease in the abdomen and pelvis. Abdominal Radiology 2023, 48: 3147-3161. PMID: 37407744, DOI: 10.1007/s00261-023-03996-w.Peer-Reviewed Original ResearchConceptsIgG4-RDPictorial reviewMultiple organsVariable imaging manifestationsImmune-mediated diseasesLymph nodesGlucocorticoid treatmentImaging manifestationsPathologic dataBile ductDefinite diagnosisRadiographic characteristicsImaging appearancesConclusionThe presenceTimely diagnosisClinical considerationsThyroid glandDiseaseSalivary glandsAbdomenPelvisSoft tissueDiagnosisGlandOrgans
2022
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases
Zhou R, Liang H, Hu W, Ding J, Li S, Chen Y, Zhao Y, Lu C, Chen F, Hu W. Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases. Ageing Research Reviews 2022, 83: 101785. PMID: 36371015, DOI: 10.1016/j.arr.2022.101785.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aAge-related diseasesTherapeutic targetPotential therapeutic targetMost age-related diseasesIon channel 1aNovel drug targetsEffective drugsMultiple organsPathophysiological processesChannel 1aDiseaseChannel family membersPharmacological propertiesImproved treatmentSuch diseasesTissue degenerationCellular apoptosisTreatmentDrug targetsFamily membersPhysiological functionsUrgent needWorldwide populationIschemiaCellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organsImmunopathological changes, complications, sequelae and immunological memory in COVID-19 patients
Yao L, Lu L, Ma W. Immunopathological changes, complications, sequelae and immunological memory in COVID-19 patients. Heliyon 2022, 8: e09302. PMID: 35497026, PMCID: PMC9040416, DOI: 10.1016/j.heliyon.2022.e09302.Peer-Reviewed Original ResearchCOVID-19 patientsSARS-CoV-2Immunological memoryMultiple organsHealth problemsSARS-CoV-2 infectionACE2 protein levelsMultidisciplinary care teamCOVID-19 survivorsLong-term health problemsSARS-CoV-2 virusImmunopathological changesImmunological changesSevere complicationsOrgan failureModerate symptomsSevere illnessCare teamFurther managementLung tissueComplicationsPatientsDisease casesMajor organsReceptors results
2021
Pathological characteristics of liver sinusoidal thrombosis in COVID‐19 patients: A series of 43 cases
Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Pathological characteristics of liver sinusoidal thrombosis in COVID‐19 patients: A series of 43 cases. Hepatology Research 2021, 51: 1000-1006. PMID: 34260803, PMCID: PMC8444906, DOI: 10.1111/hepr.13696.Peer-Reviewed Original ResearchCOVID-19 patientsVon Willebrand factorLiver injuryPatient's liverPapa Giovanni XXIII HospitalHigher serum ALTLiver sinusoidal endothelial cellsLiver biopsy samplesSinusoidal endothelial cellsSinusoidal thrombosisSerum ALTAST levelsPathological characteristicsHigher fibrinogenPlatelet microthrombiBiopsy samplesMultiple organsPatientsDisease severityCoronavirus diseaseLiverEndothelial cellsInjurySecondary damageWillebrand factorAn update: the emerging evidence of complement involvement in COVID-19
Li Q, Chen Z. An update: the emerging evidence of complement involvement in COVID-19. Medical Microbiology And Immunology 2021, 210: 101-109. PMID: 33811541, PMCID: PMC8019074, DOI: 10.1007/s00430-021-00704-7.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeCOVID-19 patientsCOVID-19Pre-clinical samplesRespiratory distress syndromePotential treatment optionCoronavirus disease 2019Host immune responseMultiorgan failureComplement involvementSystemic inflammationDistress syndromeSevere patientsOrgan damageKidney failureTreatment optionsInflammatory responseTissue injuryDisease 2019Immune responseAnimal modelsMultiple organsAbnormal activationInnate immunityComplement inhibitors
2020
Imaging Evaluation of Abdominopelvic Gunshot Trauma.
Sodagari F, Katz DS, Menias CO, Moshiri M, Pellerito JS, Mustafa A, Revzin MV. Imaging Evaluation of Abdominopelvic Gunshot Trauma. RadioGraphics 2020, 40: 1766-1788. PMID: 33001782, DOI: 10.1148/rg.2020200018.BooksConceptsGunshot woundsImportant worldwide public health problemPotential long-term complicationsWorldwide public health problemAcute trauma settingLong-term complicationsImaging modalitiesPublic health problemPrimary imaging modalityFirearm-related injuriesSeverity of injuryNonoperative managementCT findingsTrauma settingNeurologic systemsFirearm injuriesGunshot injuriesOnline supplemental materialMultiple organsClinical teamDifferent imaging modalitiesHealth problemsInjuryAnnual morbiditySubstantial injury
2017
Podoplanin is a negative regulator of Th17 inflammation
Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. Podoplanin is a negative regulator of Th17 inflammation. JCI Insight 2017, 2: e92321. PMID: 28878118, PMCID: PMC5621890, DOI: 10.1172/jci.insight.92321.Peer-Reviewed Original ResearchConceptsT cellsIL-17IL-17 secretionDistinct cytokine profilesInflammatory gene signatureTh17-polarizing conditionsTh17 cellsCytokine profileCell subsetsInflammatory responseSkin biopsiesMouse modelPDPN expressionMultiple organsSkin diseasesGene signatureInflammationLymphatic systemCLEC-2PDPNRecent dataDifferent subpopulationsCellsTranscriptional profilesShRNA geneNLRP3 Inflammasome controls adipose tissue macrophage activation during aging
Camell C, Sander J, Spadaro O, Lee A, Nguyen K, Wing A, Goldberg E, Youm Y, Rodeheffer M, Schultze J, Dixit V. NLRP3 Inflammasome controls adipose tissue macrophage activation during aging. The Journal Of Immunology 2017, 198: 154.3-154.3. DOI: 10.4049/jimmunol.198.supp.154.3.Peer-Reviewed Original ResearchAge-related inflammationMacrophage activationAT macrophagesImmune-metabolic interactionsCaspase-1 activationAdipose tissue homeostasisAge-related defectsAT inflammationOld WTVisceral adiposityImmune defectsChronic inflammationInsulin resistanceAged miceImmune populationsImmune cellsInflammatory responseMetabolic dysfunctionAge-induced changesMacrophage subsetsMultiple organsInflammationNLRP3Tissue macrophagesDegenerative disordersMicrometastasis of endometriosis to distant organs in a murine model
Samani EN, Mamillapalli R, Li F, Mutlu L, Hufnagel D, Krikun G, Taylor HS. Micrometastasis of endometriosis to distant organs in a murine model. Oncotarget 2017, 10: 2282-2291. PMID: 31040919, PMCID: PMC6481344, DOI: 10.18632/oncotarget.16889.Peer-Reviewed Original ResearchPeritoneal cavityMultiple organsDistant organsDiffuse clinical manifestationsMurine endometriosis modelReproductive-aged womenDisseminated endometriosisEndometriosis modelRetrograde menstruationClinical manifestationsEndometrial tissueEndometriotic lesionsImmunocompetent miceFallopian tubeEndometrial cellsGynecological disordersMurine modelMouse modelEndometriosisExperimental animalsEngraftmentMicrometastasisImmunofluorescence analysisOrgansDisease
2016
CD301b+ Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha
Kumamoto Y, Camporez JP, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A. CD301b+ Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha. Immunity 2016, 45: 583-596. PMID: 27566941, PMCID: PMC5033704, DOI: 10.1016/j.immuni.2016.08.002.Peer-Reviewed Original ResearchConceptsMononuclear phagocytesResistin-like molecule αResistin-like molecule alphaSignificant weight lossPositive energy balanceInsulin sensitivityGlucose metabolismAdipose tissueBody weightMultiple organsMultifunctional cytokineBody homeostasisMarked reductionHeterogeneous groupWeight lossPhagocytesMolecule αHomeostasisEnergy balanceRELMαCD301bNormoglycemiaCytokinesMacrophagesPhysiology of Weight Regulation
Chaptini L, Peikin S. Physiology of Weight Regulation. 2016, 1-4. DOI: 10.1002/9781119127437.ch102.ChaptersCentral nervous systemWeight regulationMain peripheral organsPathogenesis of obesityPeripheral organsFood intakeGastrointestinal systemObesity epidemicMultiple organsNervous systemEnergy intakeMajor deleterious effectsEnergy homeostasisTherapeutic agentsEnergy expenditurePublic healthCentral signalsDeleterious effectsIntakeOrgansPrimary formCurrent understandingObesityPathogenesisPhysiology
2015
A treatment program for babies with esophageal atresia in Belize
Rosati S, Maarouf R, Oiticica C, Lange P, Haynes J, Lanning D. A treatment program for babies with esophageal atresia in Belize. Journal Of Surgical Research 2015, 199: 72-76. PMID: 26227676, DOI: 10.1016/j.jss.2015.06.065.Peer-Reviewed Original ResearchConceptsEsophageal atresiaCongenital anomaliesWorld Pediatric ProjectPediatric surgical servicesMiddle-income countriesTracheoesophageal fistulaChildren's HospitalOperative correctionAtresiaEsophagealMortality rateInfantsMultiple organsSurgical servicesTreatment programsLack of medical facilitiesChildrenPediatric ProjectInternational careMedical facilitiesFistulaCareSurgeonsBabiesTracheoesophageal
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