2025
An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis
El Bounkari O, Zan C, Yang B, Ebert S, Wagner J, Bugar E, Kramer N, Bourilhon P, Kontos C, Zarwel M, Sinitski D, Milic J, Jansen Y, Kempf W, Sachs N, Maegdefessel L, Ji H, Gokce O, Riols F, Haid M, Gerra S, Hoffmann A, Brandhofer M, Avdic M, Bucala R, Megens R, Willemsen N, Messerer D, Schulz C, Bartelt A, Harm T, Rath D, Döring Y, Gawaz M, Weber C, Kapurniotu A, Bernhagen J. An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis. Nature Communications 2025, 16: 2297. PMID: 40055309, PMCID: PMC11889166, DOI: 10.1038/s41467-025-57540-z.Peer-Reviewed Original ResearchConceptsApoE-/- miceHyperlipidemic apoE-/- miceCoronary artery diseaseDecreased plasma lipid levelsPlasma lipid levelsHepatic lipid accumulationAtherogenic chemokinesFoam-cell formationFLIM-FRET microscopyArtery diseasePlasma concentrationsVascular inflammationInflammatory conditionsMetabolic dysfunctionAtherosclerotic patientsLipid accumulationAdvanced atherosclerosisMyocardial infarctionLipid levelsSuppressed hepatic lipid accumulationAdvanced atherogenesisCarotid plaquesDisease severityIschemic strokeChemokinesSuppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases
Rubinelli L, Manzo O, Sungho J, Del Gaudio I, Bareja R, Marino A, Palikhe S, Di Mauro V, Bucci M, Falcone D, Elemento O, Ersoy B, Diano S, Sasset L, Di Lorenzo A. Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases. Nature Communications 2025, 16: 1968. PMID: 40000621, PMCID: PMC11862206, DOI: 10.1038/s41467-025-56869-9.Peer-Reviewed Original ResearchConceptsNogo-BEndothelial dysfunctionHFD miceCardiometabolic diseasesSphingolipid signalingDevelopment of therapeutic strategiesBioactive sphingolipidsCeramide degradationSphingosine-1-phosphateHepatic glucose productionIn vivo evidenceEndothelial cellsEndothelial specific deletionCeramideBiosynthesisHigh-fat dietPathological implicationsSphingolipidsGlucose productionHFDIn vivoMale miceMetabolic dysfunctionTherapeutic strategiesMetabolic disordersIdentifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort.
John B, Bastaich D, Mezzacappa C, Ferreira R, Hentschel A, Samos A, Mahmud N, Taddei T, Kaplan D, Serper M, Dahman B. Identifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort. The American Journal Of Gastroenterology 2025 PMID: 39950372, DOI: 10.14309/ajg.0000000000003321.Peer-Reviewed Original ResearchElectronic health recordsCardiometabolic risk factorsAlcohol useChart reviewRetrospective study of participantsStudy of participantsLiver diseaseSteatotic liver diseaseIncreased alcohol intakeEligible veteransICD-9/10 codesHealth recordsNational cohortAlcohol intakeEvidence of hepatic steatosisEpidemiological studiesNatural language processing algorithmsRisk factorsStudy cohortOutcome studiesVeteransCohortClinical entityRetrospective studyMetabolic dysfunctionChapter 14 Impact of androgens on cardiovascular risk in women with polycystic ovary syndrome and transgender men
Stachenfeld N, Alexander L, Bender J, Weinzimer S, Pal L, Reckelhoff J. Chapter 14 Impact of androgens on cardiovascular risk in women with polycystic ovary syndrome and transgender men. 2025, 279-293. DOI: 10.1016/b978-0-443-22266-5.00014-8.Peer-Reviewed Original ResearchGender-affirming hormone therapyAE-PCOSTransgender menPolycystic ovary syndromeFemale endocrinopathyHigher androgenLong-term consequencesMild hypertensionEndothelial dysfunctionAssociated with endothelial dysfunctionIncreased risk of endothelial dysfunctionRisk of endothelial dysfunctionMenImpact of androgensHyperandrogenemiaHormone therapyHigher androgen levelsInfertilityAndrogen levelsCardiovascular riskVascular systemIncreased riskMetabolic dysfunctionVascular functionCardiovascular disease
2024
Acute Kidney Injury in Patients with Cirrhosis and Chronic Kidney Disease: Results from the HRS-HARMONY Consortium
St. Hillien S, Robinson J, Ouyang T, Patidar K, Belcher J, Cullaro G, Regner K, Chung R, Ufere N, Velez J, Neyra J, Asrani S, Wadei H, Teixeira J, Saly D, Levitsky J, Orman E, Sawinski D, Dageforde L, Allegretti A, Consortium H. Acute Kidney Injury in Patients with Cirrhosis and Chronic Kidney Disease: Results from the HRS-HARMONY Consortium. Clinical Gastroenterology And Hepatology 2024 PMID: 39675402, PMCID: PMC12163100, DOI: 10.1016/j.cgh.2024.10.023.Peer-Reviewed Original ResearchAcute kidney injuryChronic kidney diseaseLiver function parametersKidney diseaseKidney injuryAssociated with lower 90-day mortalityRates of intensive care unit admissionLiver diseaseAlcohol-associated liver diseaseIntensive care unit admissionMELD-Na scoreRenal replacement therapyShort-term outcomesFunction parametersComparison of outcomesPeak creatinineAdmission creatinineTransplant listing statusReplacement therapyUnit admissionPrimary outcomeCirrhosisMetabolic dysfunctionHospitalized patientsPatientsRewiring of the glymphatic landscape in metabolic disorders
Chen B, Meseguer D, Lenck S, Thomas J, Schneeberger M. Rewiring of the glymphatic landscape in metabolic disorders. Trends In Endocrinology And Metabolism 2024 PMID: 39638721, PMCID: PMC12134147, DOI: 10.1016/j.tem.2024.11.005.Peer-Reviewed Original ResearchMetabolic dysfunctionNeurological disordersBlood-brain barrier leakageCerebral blood flow disruptionBlood flow disruptionGlymphatic systemTreatment strategiesCognitive declineRisk factorsMetabolic disordersNeurovascular uncouplingBarrier leakageGlymphatic clearance systemMetabolic diseasesDisordersObesityDysfunctionThe glymphatic system as a nexus between obesity and neurological diseases
Chen B, Lenck S, Thomas J, Schneeberger M. The glymphatic system as a nexus between obesity and neurological diseases. Nature Reviews Endocrinology 2024, 21: 1-2. PMID: 39304738, PMCID: PMC11801375, DOI: 10.1038/s41574-024-01042-3.Peer-Reviewed Original ResearchDefying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity
Kim H, Dixit V. Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity. Cell Metabolism 2024, 36: 1911-1913. PMID: 39232279, DOI: 10.1016/j.cmet.2024.08.003.Peer-Reviewed Original ResearchmicroRNA-33 controls hunger signaling in hypothalamic AgRP neurons
Price N, Fernández-Tussy P, Varela L, Cardelo M, Shanabrough M, Aryal B, de Cabo R, Suárez Y, Horvath T, Fernández-Hernando C. microRNA-33 controls hunger signaling in hypothalamic AgRP neurons. Nature Communications 2024, 15: 2131. PMID: 38459068, PMCID: PMC10923783, DOI: 10.1038/s41467-024-46427-0.Peer-Reviewed Original ResearchConceptsAgRP neuronsFeeding behaviorFatty acid metabolismNon-coding RNAsMitochondrial biogenesisRegulatory pathwaysTarget genesHypothalamic AgRP neuronsExcessive nutrient intakeCentral regulatorBioenergetic processesAcid metabolismActivation of AgRP neuronsModulate feeding behaviorCentral regulation of feeding behaviorRegulation of feeding behaviorMiR-33Hunger signalsMicroRNA-33Metabolic diseasesAlternative therapeutic approachLoss of miR-33Mouse modelMetabolic dysfunctionRegulation
2023
IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING
Dixit V. IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING. Innovation In Aging 2023, 7: 140-140. PMCID: PMC10735998, DOI: 10.1093/geroni/igad104.0458.Peer-Reviewed Original ResearchCaloric restrictionAnti-inflammatory effectsAnti-inflammatory responseAge-related functional declineNegative energy balanceTissue-resident macrophagesAge-associated degenerative diseasesThymic involutionMaintenance of homeostasisMetabolic dysfunctionFunctional declineAdipose tissueInflammationResident macrophagesStudy participantsDegenerative diseasesMacrophagesKey hallmarksRNA sequence analysisMitochondrial metabolismHuman physiologyUnique regulatorCellular quiescenceMetabolismTranscriptional programsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
Doulias P, Yang H, Andreyev A, Dolatabadi N, Scott H, K Raspur C, Patel P, Nakamura T, Tannenbaum S, Ischiropoulos H, Lipton S. S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons. Cell Chemical Biology 2023, 30: 965-975.e6. PMID: 37478858, PMCID: PMC10530441, DOI: 10.1016/j.chembiol.2023.06.018.Peer-Reviewed Original ResearchConceptsTCA cycleLewy body dementiaAberrant S-nitrosylationMitochondrial metabolic dysfunctionTricarboxylic acid cyclePluripotent stem cellsMitochondrial energy metabolismParkinson's diseaseHiPSC-derived neuronsTCA enzymesMetabolic flux experimentsS-nitrosylationAcid cycleCell deathNeuronal cell deathΑ-ketoglutaratePostmortem human brainEnergy metabolismStem cellsLBD brainsDendritic lengthBioenergetic failureMetabolic dysfunctionSynaptic integrityPathophysiological relevance1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo
LAMOIA T, HUBBARD B, GUERRA M, GOODMAN R, NATHANSON M, SHULMAN G. 1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo. Diabetes 2023, 72 DOI: 10.2337/db23-1558-p.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseHepatic mitochondrial oxidationMitochondrial calcium uniporterHepatocellular redox stateFatty liver diseaseEctopic lipid accumulationType 2 diabetesHepatic lipid contentNovel therapeutic targetMitochondrial oxidationHepatic triacylglycerol contentMitochondrial calcium influxMitochondrial redox ratioMitochondrial calciumKnockout mouse modelFortress BiotechMitochondrial fat oxidationNonalcoholic steatohepatitisLiver diseaseWT miceKO miceMetabolic dysfunctionCalcium uniporterCalcium influxMouse modelA Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
Ding C, Yu Z, Sefik E, Zhou J, Kaffe E, Wang G, Li B, Flavell R, Hu W, Ye Y, Li H. A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver. Nature Aging 2023, 3: 813-828. PMID: 37277640, DOI: 10.1038/s43587-023-00428-8.Peer-Reviewed Original ResearchConceptsAged miceLiver diseaseLiver microenvironmentAge-related liver diseasesYin Yang 1Liver immune microenvironmentRegulatory T cellsTreg-specific deletionPotential therapeutic targetMitochondrial functionYang 1Treg apoptosisTreg homeostasisTreg cellsTreg functionImmune microenvironmentLiver fibrosisMetabolic dysfunctionOptimal mitochondrial functionYoung miceT cellsLiver cancerTherapeutic targetAged liverLong noncoding RNASociety of Anesthesia and Sleep Medicine Position Paper on Patient Sleep During Hospitalization
Hillman D, Carlucci M, Charchaflieh J, Cloward T, Gali B, Gay P, Lyons M, McNeill M, Singh M, Yilmaz M, Auckley D. Society of Anesthesia and Sleep Medicine Position Paper on Patient Sleep During Hospitalization. Anesthesia & Analgesia 2023, 136: 814-824. PMID: 36745563, DOI: 10.1213/ane.0000000000006395.Peer-Reviewed Original ResearchConceptsSociety of AnesthesiaPatients' sleepSleep needSleep medicineCare-related factorsImpact of hospitalizationPatient care guidelinesHealth care providersAssessment of interventionsUrinary dysfunctionMedication withdrawalImmune dysfunctionCardiovascular dysfunctionCare guidelinesVentilatory functionProinflammatory effectsPain perceptionMetabolic dysfunctionPoor sleepPsychomotor disturbanceSleep disordersCare providersSleep durationStaff educationHospitalizationSleep apnea and stroke
Geer J, Karagoz E, Yaggi H. Sleep apnea and stroke. 2023, 271-277. DOI: 10.1016/b978-0-12-822963-7.00325-x.Peer-Reviewed Original ResearchObstructive sleep apneaCerebrovascular diseaseRisk factorsImportant public health issueIndependent risk factorModifiable risk factorsMechanism of strokeSleep-disordered breathingPotential treatment modalityPublic health issueParadoxical embolismSystemic inflammationIntermittent hypoxiaSleep apneaSympathetic activationTreatment modalitiesLeading causeMetabolic dysfunctionStrokeHealth issuesApneaCurrent literatureDiseaseEmbolismAtherosclerosis
2022
Distress response in granulosa cells of women affected by PCOS with or without insulin resistance
Cozzolino M, Herraiz S, Cakiroglu Y, Garcia-Velasco JA, Tiras B, Pacheco A, Rabadan S, Kohls G, Barrio AI, Pellicer A, Seli E. Distress response in granulosa cells of women affected by PCOS with or without insulin resistance. Endocrine 2022, 79: 200-207. PMID: 36149529, DOI: 10.1007/s12020-022-03192-8.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeHomeostasis model assessmentPCOS-IRInsulin resistanceHealthy oocyte donorsCumulus GCsOvarian syndromePCOS groupPlasma glucoseCONT groupMetabolic dysfunctionPathological changesFollicular microenvironmentConclusionOur findingsOocyte donorsGranulosa cellsModel assessmentQRT-PCRWomenER stressCONTMolecular mechanismsCell stressDistress responsesGroupIdentifying the individual metabolic abnormities from a systemic perspective using whole-body PET imaging
Sun T, Wang Z, Wu Y, Gu F, Li X, Bai Y, Shen C, Hu Z, Liang D, Liu X, Zheng H, Yang Y, El Fakhri G, Zhou Y, Wang M. Identifying the individual metabolic abnormities from a systemic perspective using whole-body PET imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 2994-3004. PMID: 35567627, PMCID: PMC9106794, DOI: 10.1007/s00259-022-05832-7.Peer-Reviewed Original ResearchConceptsPET imagingNormal control databaseTotal-body imagingWhole-body PET imagingNon-invasive modalitySUV measurementsGastrointestinal bleedingMetabolic abnormitiesSystem abnormalitiesTotal bodyLung cancerHealthy subjectsMetabolic dysfunctionFocal lesionsCOVID-19 diseaseGlucose metabolismControl databaseSUV imagesPatientsAbnormal networkBiological mechanismsDiseasePETMetabolic connectivityRevisiting the Principles of Preservation in an Era of Pandemic Obesity
Langford JT, DiRito JR, Doilicho N, Chickering GR, Stern DA, Ouyang X, Mehal W, Tietjen GT. Revisiting the Principles of Preservation in an Era of Pandemic Obesity. Frontiers In Immunology 2022, 13: 830992. PMID: 35432296, PMCID: PMC9011385, DOI: 10.3389/fimmu.2022.830992.Peer-Reviewed Original ResearchConceptsDeceased donorsOrgan preservationDonor populationIschemia-reperfusion injuryCurrent obesity epidemicHealthy donor populationPandemic obesityObese donorsReperfusion injuryMetabolic dysfunctionObesity epidemicObesitySignificant declineOrgansDonorsPopulationCurrent practiceDysfunctionTransplantInjury
2021
Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice
Singh AK, Chaube B, Zhang X, Sun J, Citrin KM, Canfrán-Duque A, Aryal B, Rotllan N, Varela L, Lee RG, Horvath TL, Price N, Suárez Y, Fernandez-Hernando C. Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice. Journal Of Clinical Investigation 2021, 131 PMID: 34255741, PMCID: PMC8409581, DOI: 10.1172/jci140989.Peer-Reviewed Original ResearchDiet-induced obesityGlucose intoleranceHigh-fat fed conditionsLipoprotein lipaseExcess hepatic lipid accumulationSystemic metabolic dysfunctionRole of ANGPTL4Liver lipid metabolismHepatic lipid accumulationTargeted pharmacologic therapyANGPTL4 gene expressionMetabolic turnover studiesHepatic lipase activityObesity-associated diabetesFatty acidsNovel inhibition strategiesPharmacologic therapyLiver steatosisLiver damageLipoprotein remnantsCholesterol levelsMetabolic dysfunctionHepatic uptakeANGPTL4 deficiencyHL activityNAFLD: a multi-faceted morbid spectrum with uncertain diagnosis and complicated management.
DI Renzo C, Vitale A, D'Amico F, Cillo U. NAFLD: a multi-faceted morbid spectrum with uncertain diagnosis and complicated management. Minerva Surgery 2021, 76: 450-466. PMID: 33855376, DOI: 10.23736/s2724-5691.21.08729-0.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisNon-alcoholic steatohepatitis cirrhosisNon-alcoholic steatohepatitis patientsDegree of suspicionPost-transplant managementFatty liver diseasePatient related issuesLiver transplantationLiver diseaseEarly diagnosisMetabolic dysfunctionMorbidity spectrumComplication managementDiagnostic testsDiagnosisMetabolic issuesPatients
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply