2025
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.Peer-Reviewed Original ResearchConceptsAcute kidney injuryTubular epithelial cellsKidney injuryTubular cellsCases of acute kidney injuryImmune-mediated processPersistence of inflammationBiphasic immune responseChronic kidney diseaseCell deathTubular cell injuryLymphocyte subsetsTubular repairCell cycle arrestOutflow obstructionTEC differentiationPreclinical findingsLymphocytic infiltrationProinflammatory macrophagesKidney diseaseModulate inflammationImmune responseActivated macrophagesMetabolic reprogrammingTubular casts
2020
Dimethyl fumarate treatment shifts the immune environment toward an anti-inflammatory cell profile while maintaining protective humoral immunity
Longbrake EE, Mao-Draayer Y, Cascione M, Zielinski T, Bame E, Brassat D, Chen C, Kapadia S, Mendoza JP, Miller C, Parks B, Xing D, Robertson D. Dimethyl fumarate treatment shifts the immune environment toward an anti-inflammatory cell profile while maintaining protective humoral immunity. Multiple Sclerosis Journal 2020, 27: 883-894. PMID: 32716690, PMCID: PMC8023410, DOI: 10.1177/1352458520937282.Peer-Reviewed Original ResearchConceptsDelayed-release dimethyl fumarateAbsolute lymphocyte countT cellsMedian absolute lymphocyte countEffector memory T cellsDimethyl fumarate treatmentPhase 3b studyTotal T cellsAdverse event ratesMemory T cellsProtective humoral immunityForms of MSDMF BIDLymphocyte subsetsAdverse eventsLymphocyte countTotal IgAImmune environmentImmunoglobulin levelsNaive CD4Sustained efficacyHumoral immunityFumarate treatmentSubclass levelsCount changesT Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus
Bailin SS, McGinnis KA, McDonnell WJ, So-Armah K, Wellons M, Tracy RP, Doyle MF, Mallal S, Justice AC, Freiberg MS, Landay AL, Wanjalla C, Koethe JR. T Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2020, 222: 252-262. PMID: 32052044, PMCID: PMC7323499, DOI: 10.1093/infdis/jiaa069.Peer-Reviewed Original ResearchConceptsT cell subsetsT cellsMemory CD4Prevalent diabetesMemory T cell expansionVeterans Aging Cohort StudyMultivariable logistic regression modelHuman immunodeficiency virus (HIV) populationPrevalent diabetes casesPrevalent diabetes mellitusChronic immune activationHIV-negative individualsHIV-negative participantsT lymphocyte subsetsPrevalence of diabetesTraditional risk factorsAging Cohort StudyHuman immunodeficiency virusT cell expansionLogistic regression modelsCytomegalovirus serostatusLymphocyte subsetsCohort studyDiabetes mellitusHIV status
2019
Association between lymphocyte subsets and cytomegalovirus infection status among patients with systemic lupus erythematosus
Qin L, Qiu Z, Hsieh E, Geng T, Zhao J, Zeng X, Wan L, Xie J, Ramendra R, Routy JP, Li T. Association between lymphocyte subsets and cytomegalovirus infection status among patients with systemic lupus erythematosus. Medicine 2019, 98: e16997. PMID: 31574798, PMCID: PMC6775378, DOI: 10.1097/md.0000000000016997.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusCMV diseaseLymphocyte subsetsCMV viremiaT cellsSLE patientsCMV infectionInfection statusLupus erythematosusNatural killer cell countsMultivariable logistic regression analysisCMV infection statusCytomegalovirus infection statusEvidence of CMVHospitalized SLE patientsLymphocyte subset countsDifferent lymphocyte subsetsCMV-infected patientsT-cell lymphopeniaLogistic regression analysisTotal lymphocytesUninfected patientsClinical characteristicsSubset countsMultivariable analysisSelective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis
Ciolac D, Luessi F, Gonzalez-Escamilla G, Koirala N, Riedel C, Fleischer V, Bittner S, Krämer J, Meuth S, Muthuraman M, Groppa S. Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis. Frontiers In Immunology 2019, 10: 1779. PMID: 31417557, PMCID: PMC6682686, DOI: 10.3389/fimmu.2019.01779.Peer-Reviewed Original ResearchConceptsCortical atrophyDisease activityMultiple sclerosisDMF groupDeep GM volumesDimethyl fumarate treatmentT-cell depletionDisease-modifying drugsWhite matter damageImmune cell dynamicsDMF therapyNAT patientsStrong CD8Lymphocyte subsetsDisease durationDisease courseMS patientsCell depletionMatter damageLess atrophyFumarate treatmentTreatment paradigmBrain network responsesLesion volumeTherapy responseFunctional profile and clinical significance of major tumor infiltrating lymphocyte subsets in lung cancer-associated brain metastases.
Lu B, Gupta R, Stewart T, Kluger H, Jilaveanu L, Schalper K, Goldberg S. Functional profile and clinical significance of major tumor infiltrating lymphocyte subsets in lung cancer-associated brain metastases. Journal Of Clinical Oncology 2019, 37: 2066-2066. DOI: 10.1200/jco.2019.37.15_suppl.2066.Peer-Reviewed Original ResearchPrimary lung tumorsMajor T cell subsetsMultiplexed quantitative immunofluorescenceT cell subsetsExtracranial metastasesT cellsLung tumorsBrain metastasesQuantitative immunofluorescenceAdaptive anti-tumor responsesLow T cell infiltrationMajor clinicopathologic variablesYale Cancer CenterAdaptive immune cellsRegulatory T cellsT cell infiltrationAnti-tumor responseLonger overall survivalOptimal treatment strategyLung cancer patientsKi-67 levelsLung cancer histologyLymphocyte subsetsOverall survivalPrimary malignancyExpression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)
Carvajal-Hausdorf D, Altan M, Velcheti V, Gettinger SN, Herbst RS, Rimm DL, Schalper KA. Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC). Journal For ImmunoTherapy Of Cancer 2019, 7: 65. PMID: 30850021, PMCID: PMC6408760, DOI: 10.1186/s40425-019-0540-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overB7 AntigensB7-H1 AntigenBiomarkers, TumorFemaleFluorescent Antibody TechniqueHumansKaplan-Meier EstimateLung NeoplasmsLymphocytes, Tumor-InfiltratingMaleMiddle AgedNeoplasm GradingNeoplasm StagingPrognosisRetrospective StudiesSmall Cell Lung CarcinomaV-Set Domain-Containing T-Cell Activation Inhibitor 1ConceptsSmall cell lung cancerCell lung cancerB7-H4B7-H3Lung cancerPD-L1Non-small cell lung cancerBackgroundSmall cell lung cancerAnti-tumor immune responseHuman small cell lung cancerQuantitative immunofluorescenceB7 family ligandsLevels of TILsMultiplexed quantitative immunofluorescenceLevels of CD3Effector T cellsImmune checkpoint blockersPromising clinical activityTissue microarray formatLymphocyte subsetsCheckpoint blockersOverall survivalLung malignancyClinicopathological variablesMarker levels
2017
Host-related immunodeficiency in the development of multiple myeloma
Dosani T, Mailankody S, Korde N, Manasanch E, Bhutani M, Tageja N, Roschewski M, Kwok M, Kazandjian D, Costello R, Burton D, Zhang Y, Liewehr D, Steinberg SM, Maric I, Landgren O. Host-related immunodeficiency in the development of multiple myeloma. Leukemia & Lymphoma 2017, 59: 1127-1132. PMID: 28792255, PMCID: PMC6750254, DOI: 10.1080/10428194.2017.1361026.Peer-Reviewed Original ResearchConceptsMultiple myelomaLymphocyte subsetsCD57- subsetImmune biomarkersDevelopment of MMMyeloma precursor diseaseNK cell proportionNovel immune biomarkersProgression of SMMMultiparametric flow cytometrySMM patientsImmune changesImmune patternsClinical guidancePrecursor diseaseCell proportionFlow cytometryMGUSPotential markerImmunodeficiencySequential changesMyelomaPatientsPrecursor conditionsProgression
2016
Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia
Swann J, Woods K, Wu Y, Glanemann B, Garden O. Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia. PLOS ONE 2016, 11: e0168296. PMID: 27942026, PMCID: PMC5152924, DOI: 10.1371/journal.pone.0168296.Peer-Reviewed Original ResearchConceptsImmune-mediated haemolytic anaemiaPrimary immune-mediated haemolytic anaemiaHealthy control dogsControl dogsDisease of dogsEDTA anti-coagulated blood samplesMeasure serum concentrations of cytokinesHealthy dogsConcentrations of serum cytokinesAffected animalsInvestigate cytokine gene expressionPrincipal component analysisLymphocyte subsetsDogsAbsolute numbers of TregsExpression of cytokine genesInflammatory diseasesAutoimmune diseasesComponent analysisFrequency of regulatory T cellsHaemolytic anaemiaCytokine genesPeripheral blood mononuclear cell expressionSerum concentrations of cytokinesFrequency of TregsEffects of Systemically Administered Hydrocortisone on the Human Immunome
Olnes M, Kotliarov Y, Biancotto A, Cheung F, Chen J, Shi R, Zhou H, Wang E, Tsang J, Nussenblatt R. Effects of Systemically Administered Hydrocortisone on the Human Immunome. Scientific Reports 2016, 6: 23002. PMID: 26972611, PMCID: PMC4789739, DOI: 10.1038/srep23002.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-Lymphocyte SubsetsCluster AnalysisDose-Response Relationship, DrugFemaleFlow CytometryGene Expression ProfilingHumansHydrocortisoneImmunophenotypingInfusions, IntravenousKiller Cells, NaturalLymphocyte CountLymphocyte SubsetsMaleMiddle AgedSignal TransductionT-Lymphocyte SubsetsTime FactorsTranscriptomeYoung AdultConceptsSystemic corticosteroid administrationNK cell numbersHigh-dimensional flow cytometryEffect of corticosteroidsNatural killer cellsT cell subsetsEffects of systemicallyImmune system parametersAdministration of hydrocortisoneNF-κB signalingPaucity of dataHuman immunomeIntravenous hydrocortisoneCorticosteroid administrationLymphocyte subsetsNK cellsKiller cellsCell subsetsHC infusionsT cellsT lymphocytesHealthy humansGlucocorticoid receptorLow dosesCorticosteroids
2015
Immature B Cell Egress from Bone Marrow Is SOCS3 Independent
Nadrah K, Beck TC, Pereira JP. Immature B Cell Egress from Bone Marrow Is SOCS3 Independent. PLOS ONE 2015, 10: e0136061. PMID: 26274929, PMCID: PMC4537204, DOI: 10.1371/journal.pone.0136061.Peer-Reviewed Original ResearchConceptsB cell subsetsBone marrowBM parenchymaCell subsetsImmature-B cell egressB cell egressImmature B cell subsetsB cell distributionB lymphocyte subsetsCXCR4 desensitizationSuppressor of cytokineLymphocyte subsetsSOCS3 deficiencyPeripheral bloodSOCS3 deletionB lineage cellsB-lineage lymphocytesB cellsB cell developmentCXCR4Cell egressLigand exposureSOCS3Significant differencesHuman cell lines
2014
Large granular lymphocyte (LGL) subsets in smoldering multiple myeloma (SMM): Immunophenotypic profiles that predict progression to multiple myeloma (MM).
Dosani T, Korde N, Manasanch E, Bhutani M, Tageja N, Mailankody S, Roschewski M, Kwok M, Kazandjian D, Landgren O, Maric I. Large granular lymphocyte (LGL) subsets in smoldering multiple myeloma (SMM): Immunophenotypic profiles that predict progression to multiple myeloma (MM). Journal Of Clinical Oncology 2014, 32: 8597-8597. DOI: 10.1200/jco.2014.32.15_suppl.8597.Peer-Reviewed Original Research
2013
Cellular Composition of Cerebrospinal Fluid in HIV-1 Infected and Uninfected Subjects
Ho EL, Ronquillo R, Altmeppen H, Spudich SS, Price RW, Sinclair E. Cellular Composition of Cerebrospinal Fluid in HIV-1 Infected and Uninfected Subjects. PLOS ONE 2013, 8: e66188. PMID: 23822975, PMCID: PMC3688831, DOI: 10.1371/journal.pone.0066188.Peer-Reviewed Original ResearchConceptsT cellsCerebrospinal fluidHIV infectionMajor cellular componentCD8 ratioUninfected subjectsNK cellsB cellsHIV-1 infectionCellular compositionMulti-parameter flow cytometrySpectrum of diseaseCentral nervous systemCSF CD4Lymphocyte subsetsPeripheral lossPeripheral bloodHealthy controlsHIV-1Absolute countsCD4HIVPreferential traffickingNervous systemCD8Clinical and pharmacodynamic (PD) results of a phase I trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor.
Infante J, Powderly J, Burris H, Kittaneh M, Grice J, Smothers J, Brett S, Fleming M, May R, Marshall S, Devenport M, Pillemer S, Pardoll D, Chen L, Langermann S, LoRusso P. Clinical and pharmacodynamic (PD) results of a phase I trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor. Journal Of Clinical Oncology 2013, 31: 3044-3044. DOI: 10.1200/jco.2013.31.15_suppl.3044.Peer-Reviewed Original ResearchPD-1B7-H1T cellsFunctional T cell responsesT cell effector functionPK/PD relationshipInflammatory adverse eventsPD-1 axisAdvanced solid tumorsPre-treatment biopsiesTumor immune evasionPhase I trialT cell poolT cell responsesInitial disease progressionPD-1 receptorCell effector functionsFunctional T cellsMultiple tumor typesBaseline tumorPD-1highStable diseaseB7-DCLymphocyte subsetsAdverse events
2012
Interstitial lung disease
Murray LA, Rubinowitz A, Herzog EL. Interstitial lung disease. Current Opinion In Rheumatology 2012, 24: 656-662. PMID: 22955020, DOI: 10.1097/bor.0b013e3283588de4.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisInterstitial lung diseaseSSc-ILDClinical presentationPulmonary fibrosisLung diseaseRecent clinical trialsConcepts of pathogenesisLymphocyte subsetsOrigin of fibroblastsEpithelial injuryLung fibrosisPathologic criteriaPredictive biomarkersPathogenic roleClinical trialsDisease progressionCell injuryPutative biomarkersDiseaseFibrosisDeadly diseaseCommon formMillions of peopleDevastating disease
2002
Cytokine Regulation of Mucus Production in a Model of Allergic Asthma
Cohn L, Whittaker L, Niu N, Homer RJ. Cytokine Regulation of Mucus Production in a Model of Allergic Asthma. Novartis Foundation Symposia 2002, 248: 201-220. PMID: 12568496, DOI: 10.1002/0470860790.ch13.BooksMeSH KeywordsAdministration, InhalationAnimalsAsthmaBronchoalveolar Lavage FluidCells, CulturedExocytosisGene Expression RegulationImmunizationInterferon-gammaInterferonsInterleukin-13Interleukin-13 Receptor alpha1 SubunitInterleukin-4Interleukin-5Interleukin-9Mast CellsMiceMice, TransgenicModels, AnimalMucinsMucusOvalbuminPeptide FragmentsPulmonary EosinophiliaRadiation ChimeraReceptors, Antigen, T-Cell, alpha-betaReceptors, InterleukinReceptors, Interleukin-13Receptors, Interleukin-4Respiratory SystemSignal TransductionTh1 CellsTh2 CellsConceptsAirway inflammationTh2 cellsMucus productionTh1 cellsT cell receptor transgenic CD4Airway inflammatory infiltrateDifferent lymphocyte subsetsBone marrow chimerasAbsence of interleukinAirway obstructionAllergic asthmaLymphocyte subsetsEosinophilic inflammationMucus hyperproductionInflammatory infiltrateClinical symptomsInflammatory cellsTh2 lymphocytesRecipient miceTh cellsTransgenic CD4Respiratory tractMast cellsCytokine regulationInflammationRecent Concepts in the Pathogenesis and Treatment of Asthma
Whittaker L, Cohn L. Recent Concepts in the Pathogenesis and Treatment of Asthma. Clinical Pulmonary Medicine 2002, 9: 135-144. DOI: 10.1097/00045413-200205000-00001.Peer-Reviewed Original ResearchTreatment of asthmaLow-dose antigen exposureCD4 lymphocyte subsetsSpecific proinflammatory mediatorsMainstay of therapyAirways of asthmaticsPathogenesis of asthmaAirway hyperresponsivenessAirflow obstructionLymphocyte subsetsMucus hypersecretionAntigen exposureProinflammatory mediatorsInflammatory cytokinesTh2 lymphocytesTh1 cellsCellular inflammationCommon syndromeNovel therapiesAsthmaDisease processInflammationPathogenesisΒ-agonistsContinued investigation
2001
Immunologic recovery after autologous blood stem cell transplantation in patients with AL-amyloidosis
Akpek G, Lenz G, Lee S, Sanchorawala V, Wright D, Colarusso T, Waraska K, Lerner A, Vosburgh E, Skinner M, Comenzo R. Immunologic recovery after autologous blood stem cell transplantation in patients with AL-amyloidosis. Bone Marrow Transplantation 2001, 28: 1105-1109. PMID: 11803350, DOI: 10.1038/sj.bmt.1703298.Peer-Reviewed Original ResearchConceptsStem cell transplantationAutologous blood stem cell transplantationBlood stem cell transplantationAbsolute lymphocyteT cellsImmunoglobulin levelsCell transplantationAL amyloidosisProliferative responsePost-stem cell transplantationT cell proliferative responsesNumber of CD4Post-transplant immunosuppressionCellular immune functionSerum immunoglobulin levelsT-cell immunosuppressionCell proliferative responsesT cell proliferationB cell functionInitial study groupImmunologic recoveryLymphoid recoveryPCP pneumoniaCell immunosuppressionLymphocyte subsetsPhenotypic and Functional Analysis of Tumor-Infiltrating Lymphocytes Compared with Tumor-Associated Lymphocytes from Ascitic Fluid and Peripheral Blood Lymphocytes in Patients with Advanced Ovarian Cancer
Santin AD, Hermonat PL, Ravaggi A, Bellone S, Roman JJ, Smith CV, Pecorelli S, Radominska-Pandya A, Cannon MJ, Parham GP. Phenotypic and Functional Analysis of Tumor-Infiltrating Lymphocytes Compared with Tumor-Associated Lymphocytes from Ascitic Fluid and Peripheral Blood Lymphocytes in Patients with Advanced Ovarian Cancer. Gynecologic And Obstetric Investigation 2001, 51: 254-261. PMID: 11408737, DOI: 10.1159/000058060.Peer-Reviewed Original ResearchConceptsTumor-associated lymphocytesTumor-infiltrating lymphocytesPeripheral blood lymphocytesAdvanced ovarian cancerType 1 cytokinesT cellsBlood lymphocytesOvarian cancerAscitic fluidAntigen-experienced T lymphocytesActivation markers HLA-DREarly activation markers CD25Markers HLA-DRType 2 cytokinesActivation markers CD25Major leukocyte populationsIL-2 pathwayIL-2 receptorFunction of lymphocytesIL-2 productionLow surface expressionLymphocyte subsetsHigher proportionHLA-DRActivation markersTumor-Infiltrating Lymphocytes Contain Higher Numbers of Type 1 Cytokine Expressors and DR+ T Cells Compared with Lymphocytes from Tumor Draining Lymph Nodes and Peripheral Blood in Patients with Cancer of the Uterine Cervix
Santin A, Ravaggi A, Bellone S, Pecorelli S, Cannon M, Parham G, Hermonat P. Tumor-Infiltrating Lymphocytes Contain Higher Numbers of Type 1 Cytokine Expressors and DR+ T Cells Compared with Lymphocytes from Tumor Draining Lymph Nodes and Peripheral Blood in Patients with Cancer of the Uterine Cervix. Gynecologic Oncology 2001, 81: 424-432. PMID: 11371133, DOI: 10.1006/gyno.2001.6200.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedCarcinoma, Squamous CellCD4-CD8 RatioCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesFemaleHLA-DR AntigensHumansImmunophenotypingInterferon-gammaInterleukin-2Interleukin-4Lymph NodesLymphocytesLymphocytes, Tumor-InfiltratingMiddle AgedNeoplasm StagingReceptors, Interleukin-2Th1 CellsTh2 CellsUterine Cervical NeoplasmsConceptsType 1 cytokinesLymph nodesPeripheral bloodT cellsTumor tissueLymphocyte subsetsStage IB-IIA cervical cancerAntigen-experienced T lymphocytesIB-IIA cervical cancerTumor draining lymph nodeActivation markers HLA-DREarly activation markers CD25Draining Lymph NodesMarkers HLA-DRType 2 cytokinesCervical cancer patientsRegional lymph nodesActivation markers CD25Tumor-Infiltrating LymphocytesMajor leukocyte populationsFunction of lymphocytesCervical tumor tissuesDifferent anatomical sitesHLA-DRUterine cervix
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