2025
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Sakuma I, Gaspar R, Nasiri A, Dufour S, Kahn M, Zheng J, LaMoia T, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Huttasch M, Knebel B, Kahl S, Roden M, Samuel V, Tanaka T, Shulman G. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502978122. PMID: 40310463, PMCID: PMC12067271, DOI: 10.1073/pnas.2502978122.Peer-Reviewed Original ResearchConceptsCholine-deficient l-amino acid-defined high-fat dietBempedoic acidLiver fibrosisLiver diseaseL-amino acid-defined high-fat dietAdvanced liver diseaseCholesterol contentHSD17B13 variantsHigh-fat dietTotal liver cholesterol contentTreated miceActivate signaling pathwaysVariant rs738409Liver cholesterol contentLiver lipidsFibrotic responsePromote inflammationTherapeutic approachesSteatotic liver diseaseDietary cholesterol supplementationFibrosisHuman liver samplesI148MAntisense oligonucleotidesProgressive form
1991
Effect of Silibinin on biliary lipid composition experimental and clinical study
Nassuato G, Iemmolo R, Strazzabosco M, Lirussi F, Deana R, Francesconi M, Muraca M, Passera D, Fragasso A, Orlando R, Csomós G, Okolicsányi L. Effect of Silibinin on biliary lipid composition experimental and clinical study. Journal Of Hepatology 1991, 12: 290-295. PMID: 1940257, DOI: 10.1016/0168-8278(91)90829-z.Peer-Reviewed Original ResearchConceptsBiliary lipid compositionBiliary cholesterol concentrationTotal bile salt concentrationBile salt concentrationBile flowBiliary cholesterolCholesterol concentrationsBody weightTotal liver cholesterol contentBile saturation indexSignificant dose-dependent inhibitionEffect of silymarinLiver cholesterol contentEffect of silibininDose-dependent inhibitionCoA reductase activitySilymarin treatmentLiver cholesterolPlacebo administrationCholecystectomized patientsControl ratsClinical studiesLipid compositionSilibinin doseSilibinin
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