2025
Association between hyperkalemia and outcomes in hospitalized patients with acute kidney injury
Wang W, Yang H, Wilson F, Gallagher M, Feng Y. Association between hyperkalemia and outcomes in hospitalized patients with acute kidney injury. Intensive And Critical Care Nursing 2025, 90: 104118. PMID: 40554252, DOI: 10.1016/j.iccn.2025.104118.Peer-Reviewed Original ResearchAcute kidney injuryNadir of riskPrimary outcomeSerum potassiumKidney injuryAKI progressionAssociated with AKI progressionOdds ratioHospitalized patientsAcute kidney injury durationAcute kidney injury patientsAssociation of hyperkalemiaMeasured serum potassiumOutcomes of hospitalized patientsSerum potassium levelsRestricted cubic spline regressionDays of randomizationAcute kidney injury progressionConfidence intervalsCubic spline regressionDose-response relationshipDischarged to homeOutcomes of interestsComposite outcomeHyperkalemiaPrediction Model for Safe Contrast Volume Thresholds to Prevent Postcontrast Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair
Bader J, Li Y, Lee C, Li J, Said S, Slade M, Huang Y, Kuwayama D, Guzman R, Ochoa Chaar C. Prediction Model for Safe Contrast Volume Thresholds to Prevent Postcontrast Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair. Journal Of Vascular Surgery 2025 PMID: 40490161, DOI: 10.1016/j.jvs.2025.05.041.Peer-Reviewed Original ResearchElective endovascular abdominal aortic aneurysm repairEndovascular abdominal aortic aneurysm repairRisk of PC-AKIAbdominal aortic aneurysm repairMultivariate logistic regression analysisAortic aneurysm repairPC-AKIAcute kidney injuryLogistic regression analysisPerioperative mortalityAneurysm repairKidney injuryComplication of endovascular abdominal aortic aneurysm repairPatient characteristicsIncidence of preoperative comorbiditiesPost-contrast acute kidney injuryPostcontrast acute kidney injuryAssociated with development of chronic kidney diseaseAssociated with perioperative mortalityDevelopment of chronic kidney diseaseVascular Quality Initiative databasePreoperative patient characteristicsKaplan-Meier analysisProlonged hospital stayRenal artery stentingPredicting the Use of Dialysis for Acute Kidney Injury in Patients with Cirrhosis—Does Diagnosis Matter?
Belcher J. Predicting the Use of Dialysis for Acute Kidney Injury in Patients with Cirrhosis—Does Diagnosis Matter? Digestive Diseases And Sciences 2025, 1-3. PMID: 40471496, DOI: 10.1007/s10620-025-09143-3.Peer-Reviewed Original ResearchResolution of acute kidney injury following intensive dialysis for oxalate nephropathy.
Roth J, Buglioni A, Dahl N. Resolution of acute kidney injury following intensive dialysis for oxalate nephropathy. Clinical Nephrology 2025 PMID: 40454527, DOI: 10.5414/cn111664.Peer-Reviewed Original ResearchAcute kidney injuryOxalate nephropathyKidney injuryStage III acute kidney injuryIII acute kidney injuryResolution of acute kidney injuryUrinary excretion of oxalateIncreased urinary excretion of oxalateAbsorption of dietary oxalateDeposition of calcium oxalate crystalsIncreased absorption of dietary oxalateSerum oxalate levelsExcretion of oxalateIncreased urinary excretionChronic kidney diseaseRenal outcomesRenal recoveryEnteric hyperoxaluriaBariatric proceduresFat malabsorptionIntensive dialysisSecondary hyperoxaluriaRenal parenchymaBiliopancreatic diversionBariatric patientsThe Discrepancy Between Estimated GFR Cystatin C and Estimated GFR Creatinine at 3 Months After Hospitalization and Long-Term Adverse Outcomes
Wen Y, Srialluri N, Farrington D, Thiessen-Philbrook H, Menez S, Moledina D, Coca S, Ikizler T, Siew E, Go A, Hsu C, Himmelfarb J, Chinchilli V, Kaufman J, Kimmel P, Garg A, Grams M, Parikh C. The Discrepancy Between Estimated GFR Cystatin C and Estimated GFR Creatinine at 3 Months After Hospitalization and Long-Term Adverse Outcomes. Kidney International Reports 2025, 10: 1896-1906. DOI: 10.1016/j.ekir.2025.04.003.Peer-Reviewed Original ResearchAcute kidney injuryEnd-stage kidney diseaseHeart failure hospitalizationFailure hospitalizationCystatin CHospitalized adultsRisk of heart failure hospitalizationHigher risk of heart failure hospitalizationLong-term adverse outcomesMedian follow-upRisk of end-stage kidney diseaseAge of study participantsPrognostic valuePrognostic markerCardiac eventsKidney injuryRisk stratificationFollow-upAdverse outcomesKidney diseaseEGFRcrHospitalized patientsHigh riskSurvival analysisEGFRcysPrediction Model for Safe Contrast Volume Thresholds—Preventing Postcontrast Acute Kidney Injury to Decrease Mortality After Endovascular Abdominal Aortic Aneurysm Repair
Bader J, Li J, Li Y, Lee C, Said S, Slade M, Huang Y, Guzman R, Chaar C. Prediction Model for Safe Contrast Volume Thresholds—Preventing Postcontrast Acute Kidney Injury to Decrease Mortality After Endovascular Abdominal Aortic Aneurysm Repair. Journal Of Vascular Surgery 2025, 81: e310-e312. DOI: 10.1016/j.jvs.2025.03.457.Peer-Reviewed Original ResearchOS-038-YI Urinary neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic and prognostic biomarker of acute kidney injury in patients with decompensated cirrhosis: an individual patient data meta-analysis
Moreta M, Juanola A, Allegretti A, Piano S, Belcher J, Yewale R, Jaques D, Robinson J, Ouyang T, Gambino C, Huelin P, Ariza X, Angeli P, Parikh C, Ramakrishna B, Ponte B, Ginès P. OS-038-YI Urinary neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic and prognostic biomarker of acute kidney injury in patients with decompensated cirrhosis: an individual patient data meta-analysis. Journal Of Hepatology 2025, 82: s32-s33. DOI: 10.1016/s0168-8278(25)00353-8.Peer-Reviewed Original ResearchHospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchConceptsAcute kidney injuryClinician-level variationAssociated with acute kidney injuryAcute kidney injury ratesCardiac surgeryIntraclass correlation coefficientAdult patientsKidney injuryCohort studyCohort study of adult patientsResuscitation practicesPostoperative acute kidney injuryOperating room practiceStudy of adult patientsAssociated with increased morbidityCardiac surgical proceduresCardiac surgical databasePractice variationRBC transfusion ratesFluid volume administrationHospital-level variationMultilevel mixed-effects modelsPatient-level characteristicsRisk-adjustment modelsHealth care costsGlucarpidase for treatment of high-dose methotrexate toxicity
Gupta S, Kaunfer S, Chen K, Dias J, Vijayan A, Rajasekaran A, Prosek J, Truong H, Wood A, Bassil C, Renaghan A, Shah C, Zhang J, Glezerman I, Carlos C, Kelly K, Passero C, Drappatz J, Abudayyeh A, Shin D, Sperati C, Yelvington B, Kanduri S, Neyra J, Edmonston D, Shirali A, Bansal A, Geara A, Mithani Z, Ziolkowski S, Rashidi A, Jakubowski J, Pujari A, Bond D, Dotson E, Wall S, Patton J, Barreto J, Herrmann S, Sheikh M, Baz R, Lee J, Lucchesi N, Kolman M, Rasheed M, Afzal A, Kang D, Mahesh A, Hsu R, Nicolaysen A, Tefera K, Schretlen C, Miller R, Velez J, Flannery A, Aklilu A, Anand S, Chandrasekhara S, Donley V, Patel A, Ni J, Krishnamurthy S, Ali R, Yilmam O, Wells S, Ortega J, Green-Lingren O, Leaf R, Sise M, Nayak L, LaCasce A, Leung N, Leaf D. Glucarpidase for treatment of high-dose methotrexate toxicity. Blood 2025, 145: 1858-1869. PMID: 39760780, DOI: 10.1182/blood.2024026211.Peer-Reviewed Original ResearchAcute kidney injuryHigh-dose methotrexate toxicityKidney recoveryPatients treated with glucarpidaseRates of acute kidney injuryDay 7Time to deathHigh-dose methotrexateCox regression modelsGlucarpidase administrationDialysis-dependentMethotrexate toxicityMethotrexate initiationKidney injuryClinical dataGlucarpidaseCancer CenterNeutropeniaEnd pointsMethotrexatePatientsHospital dischargeOutcomesTarget trial emulation frameworkDaysLoss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy
Prakash S, Steers N, Li Y, Sanchez-Rodriguez E, Verbitsky M, Robbins I, Simpson J, Pathak S, Raska M, Reily C, Ng A, Liang J, DeMaria N, Katiraei A, O'Stevens K, Fischman C, Shapiro S, Kodali S, McCutchan J, Park H, Eliby D, Delsante M, Allegri L, Fiaccadori E, Bodria M, Marasa M, Raveche E, Julian B, Uhlemann A, Kiryluk K, Zhang H, D'Agati V, Sanna-Cherchi S, Novak J, Gharavi A. Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy. Journal Of Clinical Investigation 2025, 135: e181164. PMID: 40153534, PMCID: PMC12077892, DOI: 10.1172/jci181164.Peer-Reviewed Original ResearchConceptsO-glycosylationAberrant O-glycosylationIgA nephropathyMucosal immunityN-acetylgalactosaminyltransferaseElevated serum IgA levelsAdoptive-transfer experimentsB-cell homingSerum IgA levelsProtein O-glycosylationIgA-producing cellsGlomerular IgA depositionImmune-complex formationPathogenesis of IgANIgA1 hinge regionIgA1-producing cellsPeripheral bloodImpaired homingKidney injuryB cellsB lymphocytesIgA levelsLoF variantsIgA depositionGalNAc-T14Identification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation
Sun S, Ding Y, Yang D, Shen J, Zhang T, Song G, Chen X, Lin Y, Chen R. Identification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation. Frontiers In Medicine 2025, 12: 1502189. PMID: 40166075, PMCID: PMC11955678, DOI: 10.3389/fmed.2025.1502189.Peer-Reviewed Original ResearchHub genesSeptic kidney injuryAcute kidney injurySignaling pathwayDrug-gene interaction databaseKidney injuryAssociated with hub genesGene Ontology biological processesProtein-protein interactionsIntensive care unitPotential hub genesDrug-gene interactionsCandidate genesKEGG pathwaysCytoscape softwareDrug-geneSTRING databaseInfiltration of immune cellsBioinformatics analysisGene screeningSerum creatinine levelsInteraction databasesRelated genesBiological processesGenesTreatment of Extraosseous Giant Cell Tumor of Bone and Calcitriol-Mediated Hypercalcemia With Denosumab in Paget Disease
Magvanjav O, Bergwitz C. Treatment of Extraosseous Giant Cell Tumor of Bone and Calcitriol-Mediated Hypercalcemia With Denosumab in Paget Disease. JCEM Case Reports 2025, 3: luaf031. PMID: 40110572, PMCID: PMC11920620, DOI: 10.1210/jcemcr/luaf031.Peer-Reviewed Original ResearchBone-specific alkaline phosphataseGiant cell tumorCell tumorsPaget's diseaseCalcitriol-mediated hypercalcemiaOsteoclast-like giant cellsDose of denosumabTreated with bisphosphonatesReduced tumor sizeOne-time doseElevated calcitriolParathyroid autonomyPolyostotic PDBStromal mononuclear cellsPelvic massSymptomatic hypercalcemiaTumor regrowthTumor sizeParathyroid hormoneKidney injuryNormal calciumMononuclear cellsDenosumabHypercalcemiaLong-term management optionAdding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.Peer-Reviewed Original ResearchConceptsAcute kidney injuryTubular epithelial cellsKidney injuryTubular cellsCases of acute kidney injuryImmune-mediated processPersistence of inflammationBiphasic immune responseChronic kidney diseaseCell deathTubular cell injuryLymphocyte subsetsTubular repairCell cycle arrestOutflow obstructionTEC differentiationPreclinical findingsLymphocytic infiltrationProinflammatory macrophagesKidney diseaseModulate inflammationImmune responseActivated macrophagesMetabolic reprogrammingTubular castsPostoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study
Stannard B, Epstein R, Gabel E, Nadkarni G, Ouyang Y, Lin H, Salari V, Hofer I. Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study. BJA Open 2025, 14: 100384. PMID: 40129614, PMCID: PMC11930183, DOI: 10.1016/j.bjao.2025.100384.Peer-Reviewed Original ResearchPostoperative acute kidney injuryGlomerular filtration rateAcute kidney injuryRenal functionKidney injuryRates of postoperative acute kidney injuryOccurrence of postoperative acute kidney injuryAcute Kidney Injury Network classificationLong-term renal functionRetrospective propensity-matched studyCox modelPropensity-matched cohort studyPersistent renal dysfunctionIncreased hazardKaplan-Meier analysisFollow-up outpatient visitsFollow-up glomerular filtration ratePropensity-matched studyTertiary care hospitalHaemodialysis requirementRenal dysfunctionAdult patientsFiltration rateCohort studyHazard ratioAssociation of Causative Pathogens With Acute Kidney Injury in Adult Patients With Community-Onset Sepsis
Pant P, Chihara S, Krishnamoorthy V, Treggiari M, Messina J, Privratsky J, Raghunathan K, Ohnuma T. Association of Causative Pathogens With Acute Kidney Injury in Adult Patients With Community-Onset Sepsis. Critical Care Explorations 2025, 7: e1219. PMID: 39937578, PMCID: PMC11826047, DOI: 10.1097/cce.0000000000001219.Peer-Reviewed Original ResearchConceptsAcute kidney injuryOdds of acute kidney injuryDevelopment of acute kidney injuryCommunity-onset sepsisAdult patientsKidney injuryAssociated with increased odds of AKICausative pathogenPINC AI Healthcare DatabaseAcute kidney injury riskMultilevel logistic regressionGlobal Outcomes serum creatinine criteriaAssociated with decreased oddsAssociated with increased oddsSerum creatinine criteriaStage 1 AKIStage 3 AKIStage 2 AKIRetrospective cohort studyCritically ill patientsDay of admissionE. coli infectionCommunity-onsetCreatinine criteriaMedian age1599: ASSOCIATION OF ADEQUATE EMPIRIC ANTIBIOTIC THERAPY WITH ACUTE KIDNEY INJURY IN GRAM-NEGATIVE SEPSIS
Ohnuma T, Khandelwal S, Chihara S, Treggiari M, Privratsky J, Wongsripuemtet P, Messina J, Raghunathan K, Krishnamoorthy V. 1599: ASSOCIATION OF ADEQUATE EMPIRIC ANTIBIOTIC THERAPY WITH ACUTE KIDNEY INJURY IN GRAM-NEGATIVE SEPSIS. Critical Care Medicine 2025, 53 DOI: 10.1097/01.ccm.0001105060.93731.0c.Peer-Reviewed Original ResearchNon-uremic calciphylaxis: A dermatologic complication in both MASH and alcohol-associated cirrhosis
Balter D, Cao Y, Garritano J, Micevic G, Sanchez A. Non-uremic calciphylaxis: A dermatologic complication in both MASH and alcohol-associated cirrhosis. Clinical Nephrology - Case Studies 2025, 13: 8-12. PMID: 39949516, PMCID: PMC11823000, DOI: 10.5414/cncs111578.Peer-Reviewed Original ResearchNon-uremic calciphylaxisDermatological complicationsAlcohol-associated cirrhosisPainful skin lesionsAcute kidney injurySodium thiosulfate therapyInfectious complicationsKidney injuryTreatment optionsSkin biopsiesHepatic encephalopathyWork-upSkin lesionsCalciphylaxisCirrhosisComplicationsThiosulfate therapyAlcohol associationsPatientsTreatmentBiopsyPrognosisTherapyLesionsEncephalopathy
2024
POLYGENIC RISK SCORE FOR DIABETES PREDICTS POSTOPERATIVE ACUTE KIDNEY INJURY
Leis A, Mathis M, Smith J, Mukherjee B, Karvonen-Gutierrez C. POLYGENIC RISK SCORE FOR DIABETES PREDICTS POSTOPERATIVE ACUTE KIDNEY INJURY. Innovation In Aging 2024, 8: 132-133. PMCID: PMC11689292, DOI: 10.1093/geroni/igae098.0427.Peer-Reviewed Original ResearchPolygenic risk scoresAcute kidney injuryKidney Disease-Improving Global OutcomesOdds of acute kidney injuryPostoperative acute kidney injuryPredicting postoperative acute kidney injuryRisk scoreKidney injuryAcute kidney injury prevalenceLogistic regression modelsOlder adultsT2DM statusType 2 diabetesInformation biasPRS modelTransplant surgical proceduresAnalysis of outcomesGenetic cohortsDiabetes statusLowest decileIntraoperative factorsNon-cardiacNon-renalNon-urologicalSurgical proceduresOccurrence of Low Cardiac Index During Normotensive Periods in Cardiac Surgery: A Prospective Cohort Study Using Continuous Noninvasive Cardiac Output Monitoring
Goeddel L, Koffman L, Hernandez M, Whitman G, Parikh C, Lima J, Bandeen-Roche K, Zhou X, Muschelli J, Crainiceanu C, Faraday N, Brown C. Occurrence of Low Cardiac Index During Normotensive Periods in Cardiac Surgery: A Prospective Cohort Study Using Continuous Noninvasive Cardiac Output Monitoring. Anesthesia & Analgesia 2024, 140: 77-86. PMID: 39207928, PMCID: PMC11649474, DOI: 10.1213/ane.0000000000007206.Peer-Reviewed Original ResearchCentral venous pressurePre-CPBCardiac output monitoringCardiopulmonary bypassProspective cohort studyCardiac surgeryPost-CPBKidney injuryCoronary bypassRisk of postoperative acute kidney injuryCohort studyCardiac outputNoninvasive cardiac output monitoringOutput monitoringBlood pressurePostoperative acute kidney injuryProspective cohort of patientsPaired Wilcoxon rank sum testContinuous cardiac output monitoringPostoperative kidney injuryIsolated coronary bypassLow cardiac indexLow cardiac outputUS Food and Drug AdministrationAssociated with increased riskBiomarker Panels for Predicting Progression of Kidney Disease in Acute Kidney Injury Survivors
Menez S, Kerr K, Cheng S, Hu D, Thiessen-Philbrook H, Moledina D, Mansour S, Go A, Ikizler T, Kaufman J, Kimmel P, Himmelfarb J, Coca S, Parikh C. Biomarker Panels for Predicting Progression of Kidney Disease in Acute Kidney Injury Survivors. Clinical Journal Of The American Society Of Nephrology 2024, 20: 337-345. PMID: 39671257, PMCID: PMC11906013, DOI: 10.2215/cjn.0000000622.Peer-Reviewed Original ResearchAcute kidney injurySoluble tumor necrosis factor receptor 1End-stage kidney diseaseChronic kidney diseaseKidney diseaseFollow-upPost-AKI careDevelopment of end-stage kidney diseaseKidney-specific outcomesYears of follow-upCombination of clinical variablesReceiver-operating characteristic curveTumor necrosis factor receptor 1Progression of kidney diseaseSequelae of acute kidney injuryAdverse kidney eventsAge of study participantsAcute kidney injury survivorsDiuretic useEGFR declineKidney disease riskKidney eventsAKI patientsKidney injuryPost-discharge follow-up
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