2025
ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis
Slusher A, Santoro N, Vash-Margita A, Galderisi A, Hu P, Tokoglu F, Li Z, Tarabra E, Strober J, Vatner D, Shulman G, Caprio S. ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis. Journal Of Clinical Investigation 2025, 135: e184740. PMID: 40091831, PMCID: PMC11910223, DOI: 10.1172/jci184740.Peer-Reviewed Original ResearchConceptsHyperinsulinemic-euglycemic clampSubcutaneous adipose tissueInsulin resistanceAdipose triglyceride lipaseInsulin infusionOral glucose tolerance testAbdominal fat distributionGlucose tolerance testMeasuring abdominal fat distributionLower liver fatActivating adipose triglyceride lipaseMetabolic disease riskLiver fat contentEctopic lipid storageFUNDINGThis workAdipose tissue lipolysisInhibition of adipose tissue lipolysisSubcutaneous adipose tissue samplesFat distributionTolerance testInsulin exposureLiver fatInfusionGlycerol turnoverAdipose tissue
2012
Regulation of Glucose Transporter Translocation in Health and Diabetes
Bogan JS. Regulation of Glucose Transporter Translocation in Health and Diabetes. Annual Review Of Biochemistry 2012, 81: 507-532. PMID: 22482906, DOI: 10.1146/annurev-biochem-060109-094246.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTrafficking pathwaysVesicle trafficking pathwaysAS160/TBC1D4GLUT4 glucose transportersGlucose transporter translocationRab GTPasesTrafficking itineraryTransporter translocationIntracellular membranesPlasma membraneInsulin signalingGlucose transporterCell surfaceStorage vesiclesUnstimulated cellsGlucose uptakeTranslocationVesiclesInsulin exposurePathwayFat cellsPathogenesis of diabetesMembraneGTPasesVAMP2
1991
Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes
Salhanick A, Schwartz S, Amatruda J. Insulin inhibits apolipoprotein B secretion in isolated human hepatocytes. Metabolism 1991, 40: 275-279. PMID: 2000040, DOI: 10.1016/0026-0495(91)90109-a.Peer-Reviewed Original ResearchConceptsB secretionApo B secretionHuman hepatocytesApo B contentApolipoprotein B secretionInsulin-dependent inhibitionChronic insulin exposureEffect of insulinPresence of insulinHuman-derived hepatoma cell lineLiver specimensCollagenase dispersionApo BInsulin exposureHepatoma cell lineL insulinSerum-free mediumHuman hepaticInsulinSecretionInsulin controlPrimary culturesCell linesHepatocytesFurther investigation
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