2025
EPS4.09The gut's role in pulmonary and extrapulmonary manifestation of cystic fibrosis
Cigana C, Delmonte G, Faccoetti A, Veschetti L, Gianferro F, Neri A, Fiorotto R, Livraghi-Butrico A, Massimino L, Ungaro F, Bragonzi A. EPS4.09The gut's role in pulmonary and extrapulmonary manifestation of cystic fibrosis. Journal Of Cystic Fibrosis 2025, 24: s52. DOI: 10.1016/j.jcf.2025.03.626.Peer-Reviewed Original ResearchWT miceCystic fibrosisHO miceDistal organsCollaborative CrossGenetically diverse Collaborative CrossInflammatory responseBarrier integrityManifestations of cystic fibrosisMouse models of CFEnteric bacteriaIncreased gut permeabilityCFTR modulator treatmentModel of CFEnhanced defense responsesGut barrier integrityImmune response pathwaysHigher bacterial loadsExtrapulmonary manifestationsSystemic inflammationChronic infectionInflammatory profileGut permeabilityGenomic toolsMicrobiological cultureCerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome.
Bastos V, Greene K, Tabachnikova A, Bhattacharjee B, Sjögren P, Bertilson B, Reifert J, Zhang M, Kamath K, Shon J, Gehlhausen J, Guan L, VanElzakker M, Proal A, Bragée B, Iwasaki A. Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome. The Journal Of Immunology 2025 PMID: 40373264, DOI: 10.1093/jimmun/vkaf087.Peer-Reviewed Original ResearchMyalgic encephalomyelitis/chronic fatigue syndromeCerebrospinal fluidImmune phenotypeFatigue syndromeMatched healthy control subjectsAssessed plasma samplesMultiplex analysis of cytokinesHealthy control subjectsAnalysis of cerebrospinal fluidAnalysis of cytokinesTreatment developmentClinical presentationSymptom presentationMultiorgan diseaseInflammatory profileControl subjectsPathophysiological mechanismsMatrix metalloproteinase profilesDisease subgroupsME/CFS participantsClinical questionnaireMatrix metalloproteinasesMetalloproteinase profilesHigh-throughput microarrayPlasma samplesCCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models
Leser F, Júnyor F, Pagnoncelli I, Delgado A, Medeiros I, Nóbrega A, Andrade B, de Lima M, da Silva N, Jacob L, Boyé K, Geraldo L, de Souza A, Maron-Gutierrez T, Castro-Faria-Neto H, Follmer C, Braga C, Neves G, Eichmann A, Romão L, Lima F. CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models. Journal Of Neuroinflammation 2025, 22: 31. PMID: 39894839, PMCID: PMC11789347, DOI: 10.1186/s12974-024-03318-x.Peer-Reviewed Original ResearchConceptsMouse model of PDModel of PDMouse modelDopaminergic neuronsNeuron-microglia communicationNeuron-glia communicationParkinson's diseaseCCR7-dependent mannerMicroglial cell activationCCR7 expressionCCL21-CCR7Progressive degenerative diseaseCCR7 receptorMicroglial cell migrationInflammatory profileChemokine CCL21Cell activationCCL21Therapeutic strategiesChemokine inhibitorsTherapeutic implicationsMicroglial activationReceptor pathwayCCR7Behavioral deficitsBuprenorphine induces human fetal membrane sterile inflammation
Lynn T, Kelleher M, Georges H, McCauley E, Logan R, Yonkers K, Abrahams V. Buprenorphine induces human fetal membrane sterile inflammation. Journal Of Reproductive Immunology 2025, 168: 104445. PMID: 39914058, PMCID: PMC11890952, DOI: 10.1016/j.jri.2025.104445.Peer-Reviewed Original ResearchConceptsOpioid-use disorderPreterm birthToll-like receptor 4Prostaglandin E2Sterile inflammationRate of preterm birthAssociated with pregnancy complicationsInnate immune toll-like receptor 4Maternal-fetal interfaceNeutrophil chemokine IL-8Induce sterile inflammationM-opioid receptorCytokines IL-1bInflammatory cytokines IL-6Chemokine IL-8Cytokines IL-6Maternal morbidityPregnancy complicationsOpioid useOpioid-usersHuman FMInflammatory profileMembrane weakeningIL-1BPreterm
2024
Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice
Hussain H, Elumalai N, Sampath N, Shamaladevi N, Hajjar R, Druyan B, Rashed A, Ramamoorthy R, Kenyon N, Jayakumar A, Paidas M. Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice. Viruses 2024, 16: 832. PMID: 38932125, PMCID: PMC11209276, DOI: 10.3390/v16060832.Peer-Reviewed Original ResearchMurine hepatitis virus-1Inflammatory bowel diseaseCeliac diseaseImmune cell infiltrationDevelopment of targeted therapeutic strategiesGoblet cell hyperplasiaHistopathological alterationsRestore tissue homeostasisAmeliorating inflammatory responsesLung complicationsGastrointestinal complicationsMucosal inflammationLymphoid hyperplasiaCell hyperplasiaCardiovascular abnormalitiesMurine modelCell infiltrationInflammatory profileRestore tissue architectureVillous atrophyEpithelial integrityMouse modelPathological featuresTherapeutic strategiesExposure to SARS-CoV-2Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients
Abdel-Karim T, Hodges J, Herold K, Pruett T, Ramanathan K, Hering B, Dunn T, Kirchner V, Beilman G, Bellin M. Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients. Transplant International 2024, 37: 12320. PMID: 38357216, PMCID: PMC10864605, DOI: 10.3389/ti.2024.12320.Peer-Reviewed Original ResearchConceptsAlpha 1-antitrypsinTolerance testPerioperative periodAlpha-1 antitrypsin treatmentMixed meal tolerance testBenefit of etanerceptMeal tolerance testTrial of etanerceptGlucose tolerance testMonths post-TPIATIntravenous glucose tolerance testIslet autotransplant recipientsLong-term diabetes outcomesSerum A1ATEtanercept groupAdministered etanerceptAutotransplant recipientsDiabetes outcomesInflammatory profileEtanerceptIL-10Endogenous upregulationMCP-1Randomized trialsInflammatory cytokines
2022
Effects of the Seed Oil of Carica papaya Linn on Food Consumption, Adiposity, Metabolic and Inflammatory Profile of Mice Using Hyperlipidic Diet
Santana L, do Espirito Santo B, Tatara M, Negrão F, Croda J, Alves F, de Oliveira Filiú W, Cavalheiro L, Nazário C, Asato M, de Faria B, do Nascimento V, de Cássia Avellaneda Guimarães R, de Cássia Freitas K, Hiane P. Effects of the Seed Oil of Carica papaya Linn on Food Consumption, Adiposity, Metabolic and Inflammatory Profile of Mice Using Hyperlipidic Diet. Molecules 2022, 27: 6705. PMID: 36235241, PMCID: PMC9570947, DOI: 10.3390/molecules27196705.Peer-Reviewed Original ResearchConceptsOral glucose toleranceHigh-fat dietArea of adipocytesInsulin sensitivity testAcute toxicity testInflammatory profileGlucose toleranceTotal cholesterolFatty acidsIL-6Insulin resistanceMCP-1Swiss miceHyperlipidic dietLower insulinCaloric intakeMonounsaturated fatty acidsProtective effectHypoglycemic effectAdipose tissueCytokine resistanceWeight gainAdiposityFood consumptionFatty acid compositionTreating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation
Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.Peer-Reviewed Original ResearchConceptsSeptic arthritisBacterial burdenAntibiotic treatmentMurine modelTherapeutic goalsConcurrent antimicrobial therapyDistinct therapeutic goalsGeneration of inflammationMRSA septic arthritisSeptic knee arthritisInflammatory joint conditionsArticular cartilageMitigation of inflammationPost-antibiotic treatmentNovel therapeutic strategiesSeptic arthritis modelArticular cartilage damageEx vivo modelArticular cartilage integrityInflammatory arthritisInhibitors of ERKInflammatory profileMRSA infectionSynovial tissueExcessive inflammationMicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV
Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Research Neuroimaging 2022, 321: 111445. PMID: 35101828, DOI: 10.1016/j.pscychresns.2022.111445.Peer-Reviewed Original ResearchConceptsGp120 transgenic miceWildtype miceTransgenic miceCognitive deficits persistElevated inflammatory profilesPositron emission tomography studyEmission tomography studiesElevated neuroinflammationNeuroinflammatory profileInflammatory profileInflammatory insultVentral striataHIV envelopeLipopolysaccharide treatmentHIV entryMouse modelHIVBehavioral abnormalitiesDeficits persistMiceTomography studyVivo evidenceEnvelope glycoproteinPLWHNeuroinflammation
2021
Changes in Serum Fatty Acids and Inflammatory Markers in Postmenopausal Women With Breast Cancer Following Chemotherapy Treatment
Zhang Z, Ormiston K, Schnell P, Kopec R, Lustberg M, Orchard T. Changes in Serum Fatty Acids and Inflammatory Markers in Postmenopausal Women With Breast Cancer Following Chemotherapy Treatment. Current Developments In Nutrition 2021, 5: 5140290. PMCID: PMC8182042, DOI: 10.1093/cdn/nzab036_032.Peer-Reviewed Original ResearchSerum fatty acidsInflammatory markersInterleukin-6Breast cancerSerum cytokinesPostmenopausal breast cancer patientsSerum inflammatory markersBreast cancer survivorsBreast cancer patientsFatty acidsMethods Serum samplesTumor necrosis factorTotal monounsaturated FAsTotal monounsaturated fatty acidsEnzyme-linked immunoassaySerum FCytokine changesPostmenopausal womenInflammatory profileCancer survivorsInflammatory stateCancer patientsIL-8Chemotherapy treatmentNecrosis factor
2019
Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study
Lu H, Surkan P, Irwin M, Treisman G, Breen E, Sacktor N, Stall R, Wolinsky S, Jacobson L, Abraham A. Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study. American Journal Of Epidemiology 2019, 188: 1994-2003. PMID: 31642472, PMCID: PMC6825834, DOI: 10.1093/aje/kwz190.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusMulticenter AIDS Cohort StudyAIDS Cohort StudyInflammatory processCohort studyHigher oddsDepressive symptomsSoluble tumor necrosis factor receptor 2Soluble interleukin-2 receptor αTumor necrosis factor receptor 2B-cell activating factorEpidemiological Studies Depression ScaleInterleukin-2 receptor αNecrosis factor receptor 2Relevant depression symptomsSoluble interleukin-6 receptorPathogenesis of depressionHigh-risk populationRisk of depressionFactor receptor 2Interleukin-6 receptorExploratory factor analysisHIV- menHIV- participantsInflammatory profile
2016
TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage
Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. Journal Of Clinical Investigation 2016, 127: 280-292. PMID: 27893460, PMCID: PMC5199690, DOI: 10.1172/jci88647.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageTGF-β1 treatmentTGF-β1Functional recoveryBrain injuryMurine modelPlasma TGF-β1 concentrationResolution phasePhenotype of microgliaTissue-resident microgliaAcute brain injuryBlood-derived macrophagesTGF-β1 concentrationsRapid inflammatory reactionIL6 gene expressionLongitudinal transcriptional profilingInflammatory profileMicroglial phenotypeFunctional outcomeBrain parenchymaInflammatory reactionPromotes recoveryMicrogliaTherapeutic targetDevastating formResponse to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells
Moreno B, Zaretsky JM, Garcia-Diaz A, Tsoi J, Parisi G, Robert L, Meeth K, Ndoye A, Bosenberg M, Weeraratna AT, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Ribas A. Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells. Cancer Immunology Research 2016, 4: 845-857. PMID: 27589875, PMCID: PMC5050168, DOI: 10.1158/2326-6066.cir-16-0060.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorDendritic CellsInterferon-gammaLymphocytes, Tumor-InfiltratingMacrophagesMelanomaMice, Inbred C57BLMutationProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins B-rafXenograft Model Antitumor AssaysConceptsPD-1 blockade therapyPD-1 blockadeCD8 T cellsBlockade therapyDendritic cellsT cellsTumor modelEffector T cell functionSyngeneic murine tumor modelsAntitumor activityPD-L1 expressionT cell primingImmune cell recruitmentT cell functionTumor-associated macrophagesMurine tumor modelsTumor-host interactionsStrong antitumor activityCD80/86 costimulationL1 therapyInflammatory profileClinical benefitMHC-IIPeripheral tissuesCell recruitment
2015
Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis
Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Science Translational Medicine 2015, 7: 287ra74. PMID: 25972006, PMCID: PMC4497538, DOI: 10.1126/scitranslmed.aaa8038.Peer-Reviewed Original ResearchConceptsMyelin-reactive T cellsMultiple sclerosisT cellsHealthy controlsT cell librariesT helper cell 17Antigen-specific T cellsGene signatureMore IL-10More proinflammatory cytokinesAutoreactive T cellsIL-10 productionHuman autoimmune diseasesGranulocyte-macrophage colony-stimulating factorProduction of interferonColony-stimulating factorMyelin antigensTh17 cellsIL-10Inflammatory profileInterleukin-17Proinflammatory cytokinesAutoimmune diseasesDisease progressionHealthy subjects
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