2025
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.Peer-Reviewed Original ResearchConceptsAcute kidney injuryTubular epithelial cellsKidney injuryTubular cellsCases of acute kidney injuryImmune-mediated processPersistence of inflammationBiphasic immune responseChronic kidney diseaseCell deathTubular cell injuryLymphocyte subsetsTubular repairCell cycle arrestOutflow obstructionTEC differentiationPreclinical findingsLymphocytic infiltrationProinflammatory macrophagesKidney diseaseModulate inflammationImmune responseActivated macrophagesMetabolic reprogrammingTubular casts
2015
IgG4-Sclerosing Cholangitis in a Pediatric Patient
Rosen D, Thung S, Sheflin-Findling S, Lai J, Rosen A, Arnon R, Chu J. IgG4-Sclerosing Cholangitis in a Pediatric Patient. Seminars In Liver Disease 2015, 35: 089-094. PMID: 25632939, DOI: 10.1055/s-0034-1398475.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisIgG4-SCPediatric patientsSerum IgG4Characteristic pathology findingsBile duct stricturesImmune-mediated processElevated serum IgG4Bile duct wallReversal of diseaseAsymptomatic elevationObliterative phlebitisAbdominal painSclerosing cholangitisDuct stricturesAutoimmune pancreatitisObstructive jaundicePediatric gastroenterologistsPathology findingsExtensive fibrosisLymphoplasmacellular infiltrationLiver enzymesDisease entityAppropriate treatmentPlasma cells
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