2025
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Sakuma I, Gaspar R, Nasiri A, Dufour S, Kahn M, Zheng J, LaMoia T, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Huttasch M, Knebel B, Kahl S, Roden M, Samuel V, Tanaka T, Shulman G. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502978122. PMID: 40310463, PMCID: PMC12067271, DOI: 10.1073/pnas.2502978122.Peer-Reviewed Original ResearchConceptsCholine-deficient l-amino acid-defined high-fat dietBempedoic acidLiver fibrosisLiver diseaseL-amino acid-defined high-fat dietAdvanced liver diseaseCholesterol contentHSD17B13 variantsHigh-fat dietTotal liver cholesterol contentTreated miceActivate signaling pathwaysVariant rs738409Liver cholesterol contentLiver lipidsFibrotic responsePromote inflammationTherapeutic approachesSteatotic liver diseaseDietary cholesterol supplementationFibrosisHuman liver samplesI148MAntisense oligonucleotidesProgressive form
2024
1574-P: Catecholamine-Induced Adipose Lipolysis Drives Hepatic Steatosis in Pnpla3I148M Knockin Mice
PRAKASH GOLLA J, SUH R, PAOLELLA L, STROBER J, ZHANG F, PHILBRICK W, VATNER D. 1574-P: Catecholamine-Induced Adipose Lipolysis Drives Hepatic Steatosis in Pnpla3I148M Knockin Mice. Diabetes 2024, 73 DOI: 10.2337/db24-1574-p.Peer-Reviewed Original ResearchWhite adipose tissueM miceDecreased hepatic triglycerideHepatic steatosisMutant miceCatecholamine responseGonadal white adipose tissueBeta-adrenergic blockadeHepatic triglycerideWhite adipose tissue functionResponse to CLHigh-sucrose dietHepatic triglyceride contentWT miceM mutationExtrahepatic sourcesAdrenergic blockadeHepatic triglyceride biosynthesisAgonist CLEx vivoInsulin responseI148MMiceFatty liverAdipose tissue
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply