2025
Partial Hydatidiform Mole
Buza N. Partial Hydatidiform Mole. 2025, 83-96. DOI: 10.1007/978-3-031-83545-2_6.Peer-Reviewed Original ResearchPartial hydatidiform moleGestational trophoblastic neoplasiaGestational trophoblastic diseaseHydatidiform moleComplete moleTrophoblastic hyperplasiaPersistent gestational trophoblastic diseaseNon-neoplastic proliferationTriploid gestationsTrophoblastic neoplasiaCytogenetic abnormalitiesTrophoblastic diseaseClinical presentationVillous trophoblastDiagnostic accuracyHydatidiformFlow cytometryTriploid karyotypeHyperplasiaFocal sparingVilliGestationFetusesEmbryo/fetusNeoplasiaErgonomic Challenges and Considerations in Endoscopic Treatment of Benign Prostatic Hyperplasia
Gardezi M, Sanekommu G, Lee J. Ergonomic Challenges and Considerations in Endoscopic Treatment of Benign Prostatic Hyperplasia. Current Urology Reports 2025, 26: 37. PMID: 40232581, DOI: 10.1007/s11934-025-01266-4.Peer-Reviewed Original ResearchConceptsEndoscopic treatment of benign prostatic hyperplasiaTreatment of benign prostatic hyperplasiaBenign prostatic hyperplasiaProstatic hyperplasiaEndoscopic treatmentModifiable risk factorsReviewThe present reviewEnhance surgical performanceMusculoskeletal painSummaryThe combinationHyperplasiaRisk factorsProlonged proceduresOperating roomSurgeonsSurgeon communitySurgical performancePresent reviewSurgeon educationUrologyErgonomic challengesOptimal ergonomicsErgonomic factorsRising volumeErgonomic considerationsDietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Wing A, Jeffery E, Church C, Goodell J, Saavedra-Peña R, Saha M, Holtrup B, Voisin M, Alavi N, Floody M, Wang Z, Zapadka T, Garabedian M, Varshney R, Rudolph M, Rodeheffer M. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Reports 2025, 44: 115527. PMID: 40208790, PMCID: PMC12073628, DOI: 10.1016/j.celrep.2025.115527.Peer-Reviewed Original ResearchAdipocyte precursor cellsDietary fatPlasma monounsaturated fatty acidsAssociated with human obesityHuman adipocyte precursor cellsMonounsaturated fatty acidsDietary fat compositionDietary screeningFatty acidsDietary fatty acidsHuman obesityAdipose expansionMetabolic healthObesity epidemicAkt2 signalingLXR activationPrecursor cellsAdipose biologyOleic acidHyperplasiaObesityAdipocyte hyperplasiaDietary oleic acidPhysiological regulationAdipogenesisHepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk
Bao K, Berger J, Na E, Su Q, Halasz G, Sleeman M, Okamoto H. Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk. Diabetes 2025, 74: 885-897. PMID: 40095004, PMCID: PMC12097458, DOI: 10.2337/db24-0958.Peer-Reviewed Original ResearchConceptsAmino acid catabolismGlucagon receptorControlling amino acid metabolismDownstream effectorsGlucagon receptor blockadeA cellsElevated plasma amino acidsAmino acidsAlpha cell massPlasma amino acidsCatabolism of amino acidsPKA knockdownAmino acid metabolismGlucagon-stimulated hepatic glucose productionCatabolic genesGcgr signalingPancreatic A cellsEPAC2 knockdownGNASHyperplasiaHepatic glucose productionDownstream factorsAcid metabolismCell massEpac2
2024
Low Dose Tamoxifen for Breast Cancer Prevention: A Real-World Experience
Patel R, Jin C, Jaber D, Casasanta N, Jain M, Fu W, Wu C, Moshier E, Tiersten A. Low Dose Tamoxifen for Breast Cancer Prevention: A Real-World Experience. Clinical Breast Cancer 2024, 25: 283-290. PMID: 39837695, DOI: 10.1016/j.clbc.2024.12.020.Peer-Reviewed Original ResearchConceptsLobular carcinoma in situDuctal carcinoma in situLow dose tamoxifenCarcinoma in situAtypical hyperplasiaBreast cancer preventionLog-binomial modelsRetrospective chart review of womenPoison regression modelsChart review of womenIncidence rate of AEFrequency of adverse eventsReview of womenCompare adverse event ratesRetrospective chart reviewHigh-risk lesionsAdverse event ratesCancer preventionIncidence rateAromatase inhibitorsAtypical lesionsAdverse eventsRegression modelsDisease characteristicsHyperplasiaTRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis
Lin Y, Chen Y, Hu W, Liu X, Hao W, Xing J, Ding J, Xu Y, Yao F, Zhao Y, Wang K, Li S, Yu Q, Hu W, Zhou R. TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis. International Immunopharmacology 2024, 132: 111933. PMID: 38581988, DOI: 10.1016/j.intimp.2024.111933.Peer-Reviewed Original ResearchConceptsTransient receptor potential melastatin 7Rheumatoid arthritisInhibition of transient receptor potential melastatin 7Human RA patientsSynovial hyperplasiaAdjuvant-induced arthritis ratsIncreased TRPM7 expressionIL-6 mRNATreatment of RAPathogenesis of RAFibroblast-like synoviocytesTRPM7 silencingProgression of rheumatoid arthritisTRPM7 expressionChannel inhibitionCation channelsRA patientsMetastasisPharmacological inhibitionArthritis ratsInflammationNuclear translocationSynoviocyte proliferationHyperplasiaProliferationDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, PMCID: PMC11380968, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVF
2023
Liver and Biliary Tract
Wang X, Cai G. Liver and Biliary Tract. 2023, 247-266. DOI: 10.1007/978-3-031-44289-6_14.Peer-Reviewed Original ResearchBiliary tractPrimary sclerosis cholangitisExtrahepatic biliary tractRelevant clinical historyEchinococcal cystsLiver cystsAmebic abscessClinical historyNonneoplastic lesionsNonneoplastic disordersCytomorphologic featuresBenign lesionsSolid lesionsHepatocyte hyperplasiaMalignant counterpartsInfectious entitiesLesionsCystsLiverTractCholangitisCirrhosisAbscessStentingHyperplasiaEstradiol cycling drives female obesogenic adipocyte hyperplasia
del M. Saavedra-Peña R, Taylor N, Flannery C, Rodeheffer M. Estradiol cycling drives female obesogenic adipocyte hyperplasia. Cell Reports 2023, 42: 112390. PMID: 37053070, PMCID: PMC10567995, DOI: 10.1016/j.celrep.2023.112390.Peer-Reviewed Original ResearchConceptsAdipocyte precursor cellsHigh-fat dietAdipocyte hyperplasiaHFD feedingVisceral WATDifferential fat distributionAdipose tissue distributionEstrogen receptor αWAT distributionFat distributionOvariectomized femalesHyperplasiaMice showEstrous cycleReceptor αTissue distributionPrecursor cellsObesityAPC proliferationTissue microenvironmentProliferationFemalesSexOnsetFeedingPrimary hypothyroidism presenting as neuropsychiatric symptoms and pituitary enlargement in a young woman: illustrative case
Haider S, Templeton K, Omay S, Inzucchi S. Primary hypothyroidism presenting as neuropsychiatric symptoms and pituitary enlargement in a young woman: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 5: case22496. PMID: 36794728, PMCID: PMC10550602, DOI: 10.3171/case22496.Peer-Reviewed Original ResearchPituitary enlargementPrimary hypothyroidismPituitary hyperplasiaElevated thyroid-stimulating hormoneSevere primary hypothyroidismThyroid-stimulating hormoneComputed tomography scanMagnetic resonance imagingLevothyroxine replacementHormone replacementNeuropsychiatric symptomsRare presentationSellar massSurgical interventionTomography scanCommon causePituitary adenomasPhysiological causesResonance imagingPsychiatry departmentYoung womenHypothyroidismHyperplasiaSymptomsEnlargement
2022
Chronic cholecystitis from Raoultella planticola infection associated with adenomyomatous hyperplasia
Doherty G, Kreinces J, Souza F, Kim D. Chronic cholecystitis from Raoultella planticola infection associated with adenomyomatous hyperplasia. Journal Of Surgical Case Reports 2022, 2022: rjac529. PMID: 36452290, PMCID: PMC9704786, DOI: 10.1093/jscr/rjac529.Peer-Reviewed Original ResearchAdenomyomatous hyperplasiaChronic cholecystitisBlood culturesEvidence of cholecystitisLower abdominal painNegative rod bacteremiaHistory of immunosuppressionSignificant risk factorsBiliary ductal dilatationMagnetic resonance cholangiopancreatographyPositive blood culturesUnderlying malignancyAbdominal painBile culturesDuctal dilatationDiabetes mellitusLaparoscopic cholecystectomyPiperacillin-tazobactamResonance cholangiopancreatographyRisk factorsCholecystitisComputed tomographyHyperplasiaInfectionPatientsS188 Idiopathic Myointimal Hyperplasia of Mesenteric Veins: A Systematic Review and Individual Patient Regression Analysis
Rozner R, Gisriel S, Damianos J, Grimshaw A, Rizwan R, Nawaz A, Chan K, Wan D, Pantel H, Bhutta A, Fenster M, Brandt L, Barbieri A, Robert M, Feuerstadt P, Li D. S188 Idiopathic Myointimal Hyperplasia of Mesenteric Veins: A Systematic Review and Individual Patient Regression Analysis. The American Journal Of Gastroenterology 2022, 117: e137-e138. DOI: 10.14309/01.ajg.0000857392.98857.01.Peer-Reviewed Original ResearchProminent Pseudoacini in Focal Nodular Hyperplasia
Wang D, González IA, Russo PA, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia. The American Journal Of Surgical Pathology 2022, 46: 1380-1385. PMID: 35749760, DOI: 10.1097/pas.0000000000001931.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaHepatocellular carcinomaNodular hyperplasiaFNH casesPotential diagnostic pitfallInspissated bileChronic cholestasisInitial biopsyPathologic featuresClinicopathologic correlationDiagnostic challengeNeedle biopsyDifferential diagnosisHepatocellular neoplasmsHepatocellular adenomaDiagnostic pitfallsMorphologic featuresLobular parenchymaStaining patternPseudoaciniBiliary transdifferentiationBiopsyHyperplasiaLesionsHepatocytes
2021
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: clinical characteristics and progression to carcinoid tumour
Sun TY, Hwang G, Pancirer D, Hornbacker K, Codima A, Lui NS, Raj R, Kunz P, Padda SK. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: clinical characteristics and progression to carcinoid tumour. European Respiratory Journal 2021, 59: 2101058. PMID: 34795035, PMCID: PMC8792466, DOI: 10.1183/13993003.01058-2021.Peer-Reviewed Original ResearchConceptsDiffuse idiopathic pulmonary neuroendocrine cell hyperplasiaIdiopathic pulmonary neuroendocrine cell hyperplasiaPulmonary neuroendocrine cell hyperplasiaElderly white womenNeuroendocrine cell hyperplasiaBasement membraneSuch hyperplasiaClinical characteristicsCarcinoid tumorsCell hyperplasiaIdentifiable causeLung diseasePreinvasive lesionsRare diseaseTumorsWhite womenNeuroendocrine cellsLung nodulesHyperplasiaTumourletsDiseaseNodulesNeoplasmsLesionsYearsDesmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons
Wang MZ, McNiff JM, McCalmont TH, LeBoit PE. Desmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons. American Journal Of Dermatopathology 2021, 43: 788-793. PMID: 33899770, DOI: 10.1097/dad.0000000000001922.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaCell carcinomaImmunohistochemical profileMorphoeic basal cell carcinomaSquamous cell carcinomaMicrocystic adnexal carcinomaBasal cell carcinomaFollicular germinative cellsMedian ageBer-EP4Clinical manifestationsAdnexal carcinomaMalignant neoplasmsFibrotic stromaBasaloid cellsEpidermal hyperplasiaPseudocarcinomatous hyperplasiaMerkel cellsSurface epitheliumAccurate diagnosisCarcinomaTrichoepitheliomaGerminative cellsBasal layerHyperplasia
2020
A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin
Kondo J, Huh WJ, Franklin JL, Heinrich MC, Rubin BP, Coffey RJ. A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin. The Journal Of Pathology 2020, 252: 441-450. PMID: 32944951, PMCID: PMC7802691, DOI: 10.1002/path.5552.Peer-Reviewed Original ResearchConceptsGastrointestinal stromal tumorsSmooth muscle cellsICC hyperplasiaMuscle cellsTyrosine kinase inhibitor imatinibFrequent driver eventsCommon mesenchymal tumorsSmooth muscle cell progenitorsDevelopment of GISTsKinase inhibitor imatinibLoss of Trp53ICC-DMPGut motilityStromal tumorsMesenchymal tumorsMouse modelInhibitor imatinibInterstitial cellsMutant BRAFBRAF expressionTumorsBRAFHyperplasiaCell progenitorsDriver eventsManagement of recurrent bilateral multifocal pseudoangiomatous stromal hyperplasia (PASH)
Xu X, Persing SM, Allam O, Park KE, Mozaffari MA, Lannin DR, Bossuyt V, Alperovich M. Management of recurrent bilateral multifocal pseudoangiomatous stromal hyperplasia (PASH). The Breast Journal 2020, 26: 1814-1817. PMID: 32562297, DOI: 10.1111/tbj.13950.Peer-Reviewed Original ResearchConceptsPseudoangiomatous stromal hyperplasiaStromal hyperplasiaBilateral mastectomyReduction mammoplastyTwo-stage implant-based breast reconstructionImplant-based breast reconstructionExcellent aesthetic outcomesPain reliefBreast enlargementStandard treatmentBreast reconstructionFocal excisionReconstructive surgeryRare caseConservative optionsAesthetic outcomeHyperplastic conditionsMastectomyHyperplasiaMammoplastyMacromastiaPatientsSurgeryExcisionBreastModern best practice in the management of benign prostatic hyperplasia in the elderly
Bortnick E, Brown C, Simma-Chiang V, Kaplan S. Modern best practice in the management of benign prostatic hyperplasia in the elderly. Therapeutic Advances In Urology 2020, 12: 1756287220929486. PMID: 32547642, PMCID: PMC7273551, DOI: 10.1177/1756287220929486.Peer-Reviewed Original ResearchBenign prostatic hyperplasiaProstatic hyperplasiaManagement of benign prostatic hyperplasiaTreatment of benign prostatic hyperplasiaElderly malesUrinary tract symptomsMinimally invasive techniquesLong-term riskTransurethral resectionMedical therapySurgical optionsEjaculatory functionInvasive techniquesGeneral anesthesiaTreatment planningSide effectsGold standardPatientsProcedural techniquesDebilitating diseaseHyperplasiaEffective alternativeTreatmentMaleUroLift
2019
Angiolymphoid Hyperplasia with Eosinophilia with Clinical Presentation Concerning for Juvenile Temporal Arteritis
Li E, Sinard J, Distefano A, Sohrab M. Angiolymphoid Hyperplasia with Eosinophilia with Clinical Presentation Concerning for Juvenile Temporal Arteritis. Ocular Oncology And Pathology 2019, 6: 25-30. PMID: 32002401, PMCID: PMC6984143, DOI: 10.1159/000500361.Peer-Reviewed Original ResearchJuvenile temporal arteritisTemporal arteritisRare eosinophilic dermatosisMagnetic resonance imagingAngiolymphoid hyperplasiaPreoperative workupClinical presentationEosinophilic dermatosisPediatric populationUnknown etiologyVascular tumorsExcisional biopsyFinal diagnosisMonths durationRecent traumaDoppler ultrasoundRight eyebrowResonance imagingComplete examinationArteritisEosinophiliaHyperplasiaWorkupDiagnosisDurationMedial artery calcification increases neointimal hyperplasia after balloon injury
Marshall AP, Luo W, Wang XL, Lin T, Cai Y, Guzman RJ. Medial artery calcification increases neointimal hyperplasia after balloon injury. Scientific Reports 2019, 9: 8193. PMID: 31160618, PMCID: PMC6547750, DOI: 10.1038/s41598-019-44668-4.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsBone Morphogenetic Protein 2CalcinosisCalcium ChlorideCarotid ArteriesCarotid Artery InjuriesCell ProliferationCoronary RestenosisDisease Models, AnimalHyperplasiaMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaProliferating Cell Nuclear AntigenRatsRats, Sprague-DawleyTunica IntimaConceptsSmooth muscle cellsNeointimal hyperplasiaBalloon injuryArterial calcificationCalcified arteriesMedial smooth muscle cellsCell nuclear antigen stainingBalloon catheter injuryMedial artery calcificationTime of injuryVascular smooth muscle cellsNeointimal cell proliferationCell proliferationCatheter injuryArtery calcificationMedial calcificationSubcutaneous injectionAntigen stainingVitamin D3Rat carotidEffect of calcificationArteryHyperplasiaAdventitial applicationInjury
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