2025
SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy
Ding C, Ndiaye P, Campbell S, Fry M, Gong J, Wienbar S, Gibbs W, Morquette P, Chao L, H. M, Schwarz T. SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy. Journal Of Clinical Investigation 2025, 135: e191315. PMID: 40344041, PMCID: PMC12165793, DOI: 10.1172/jci191315.Peer-Reviewed Original ResearchConceptsAutosomal dominant optic atrophyRetinal ganglion cellsOptic atrophy type 1Dominant optic atrophyOptic atrophyMouse modelRGC degenerationGanglion cellsOptic nerve degenerationHereditary optic neuropathyMitochondrial intermembrane spaceRGC lossOptic neuropathyRGC functionVision lossNerve degenerationIntermembrane spaceType 1Mitochondrial fragmentationDegeneration phenotypeMitochondrial defectsTherapeutic targetMembrane dynamicsMiceTIR motifOptic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell
Zapadka T, Tran N, Demb J. Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell. The Journal Of Physiology 2025 PMID: 39985791, DOI: 10.1113/jp286414.Peer-Reviewed Original ResearchOptic nerve crushRetinal ganglion cellsOptic nerveGanglion cellsSynaptic inputsVoltage-gated sodium channel currentsRetinal ganglion cell typesVoltage-gatedRetinal ganglion cell survivalChelation of intracellular calciumResting membrane potentialOptic nerve injuryVoltage-gated currentsAxonal injurySodium channel currentsRetinal ganglion cell axonsRGC typesAlpha retinal ganglion cellsAxon initial segmentIntracellular calciumRate of survivalNerve injuryElectrophysiological propertiesNerve crushIntrinsic excitability
2024
Specific retinal neurons regulate context-dependent defensive responses to visual threat
Lee T, Weinberg-Wolf H, Zapadka T, Rudenko A, Demb J, Kim I. Specific retinal neurons regulate context-dependent defensive responses to visual threat. PNAS Nexus 2024, 3: pgae423. PMID: 39359403, PMCID: PMC11443969, DOI: 10.1093/pnasnexus/pgae423.Peer-Reviewed Original ResearchRetinal ganglion cellsBehavioral responsesRetinal ganglion cell typesVisual threatAlpha retinal ganglion cellsLooming stimuliThreatening stimuliMature miceGanglion cellsBehavioral reactionsUnique contributionsCell ablationVisual pathwayOutput neuronsEarly visual pathwayStimuliContextual signalsDefense responsesAerial predatorsEnvironmental contextPresynaptic Proteins and Their Roles in Visual Processing by the Retina
Thoreson W, Zenisek D. Presynaptic Proteins and Their Roles in Visual Processing by the Retina. Annual Review Of Vision Science 2024, 10: 347-375. PMID: 38621251, PMCID: PMC11536687, DOI: 10.1146/annurev-vision-101322-111204.Peer-Reviewed Original ResearchExtract critical featuresGanglion cellsHorizontal cellsRetinal ganglion cellsDendritic synapsesSynaptic feedbackSpatial frequencySynaptic connectionsRetinaBipolar cellsSynapse typesVisual worldSense of visionRibbon synapsesPresynaptic moleculesMotion directionTemporal frequencyCritical featuresPhotoreceptorsPresynaptic proteinsCells
2023
The Effects of Aging on Rod Bipolar Cell Ribbon Synapses
Shrestha A, Rameshkumar N, Boff J, Rajmanna R, Chandrasegaran T, Frederick C, Zenisek D, Vaithianathan T. The Effects of Aging on Rod Bipolar Cell Ribbon Synapses. Cells 2023, 12: 2385. PMID: 37830599, PMCID: PMC10572008, DOI: 10.3390/cells12192385.Peer-Reviewed Original ResearchConceptsRod bipolar cellsRibbon synapsesSynaptic ribbonsCalcium currentBipolar cellsRetinal ganglion cellsAge-related morphological changesBipolar cell ribbon synapsesBipolar cell terminalsGlobal health concernAge-related visual impairmentAge-related changesPlexiform layerGanglion cellsInner nuclearCochlear cellsSensory alterationsCell terminalsVisual impairmentFunctional changesHealth concernCalcium signalsSynapsesCalcium dynamicsRetinaHirschsprung's disease associated enterocolitis: A comprehensive review
Gershon E, Rodriguez L, Arbizu R. Hirschsprung's disease associated enterocolitis: A comprehensive review. World Journal Of Clinical Pediatrics 2023, 12: 68-76. PMID: 37342453, PMCID: PMC10278080, DOI: 10.5409/wjcp.v12.i3.68.Peer-Reviewed Original ResearchHirschsprung’s disease associated enterocolitisHirschsprung's diseaseAffected bowel segmentCurrent therapeutic optionsIntestinal barrier functionIntestinal dysmotilityInflammatory complicationsPostoperative periodDistal bowelSurgical treatmentAssociated enterocolitisBowel segmentsClinical presentationFunctional obstructionTherapeutic optionsMucosal defenseGanglion cellsNeural crest cellsBarrier functionCongenital disorderDiseaseDiagnosisCrest cellsComprehensive reviewTreatment
2022
Focal electrical stimulation of human retinal ganglion cells for vision restoration
Madugula S, Gogliettino A, Zaidi M, Aggarwal G, Kling A, Shah N, Brown J, Vilkhu R, Hays M, Nguyen H, Fan V, Wu E, Hottowy P, Sher A, Litke A, Silva R, Chichilnisky E. Focal electrical stimulation of human retinal ganglion cells for vision restoration. Journal Of Neural Engineering 2022, 19: 066040. PMID: 36533865, PMCID: PMC10010036, DOI: 10.1088/1741-2552/aca5b5.Peer-Reviewed Original ResearchConceptsHuman retinal ganglion cellsRetinal ganglion cellsElectrical stimulationVision restorationGanglion cellsExtracellular electrical stimulationPrimate retinal ganglion cellsFocal electrical stimulationRetina ex vivoRGC typesAxon bundlesEx vivoHuman retinaStimulationStimulation algorithmMulti-electrode arraysSimultaneous recordingEpiretinal implantsRetinaSimultaneous activationRetinal implantsCell typesNeural codeActivation propertiesMacaques
2021
Automatic Identification of Axon Bundle Activation for Epiretinal Prosthesis
Tandon P, Bhaskhar N, Shah N, Madugula S, Grosberg L, Fan VH, Hottowy P, Sher A, Litke AM, Chichilnisky EJ, Mitra S. Automatic Identification of Axon Bundle Activation for Epiretinal Prosthesis. IEEE Transactions On Neural Systems And Rehabilitation Engineering 2021, 29: 2496-2502. PMID: 34784278, PMCID: PMC8860174, DOI: 10.1109/tnsre.2021.3128486.Peer-Reviewed Original ResearchConceptsAxon bundle activationRetinal ganglion cellsBundle activationAxonal stimulationEpiretinal prosthesisEx vivo stimulationStimulation current amplitudeGanglion cellsReceptive field locationMacaque retinaVivo stimulationElectrical stimulationAxon bundlesAxonal spikesStimulationProsthesisCortical implantsRetinal prosthesisActivationRetinal implantsVisual perceptsElectrical recordingsCellsInadvertent activationImplantsPreservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetinaOptic nerve regeneration screen identifies multiple genes restricting adult neural repair
Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Reports 2021, 34: 108777. PMID: 33657370, PMCID: PMC8009559, DOI: 10.1016/j.celrep.2021.108777.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCRISPR-Cas SystemsDependovirusFemaleGene EditingGene Expression RegulationGenetic Association StudiesHEK293 CellsHumansInterleukinsMaleMAP Kinase Kinase KinasesMice, Inbred C57BLMice, TransgenicNerve RegenerationNeurogenesisOptic NerveOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionSTAT3 Transcription FactorConceptsOptic nerve crushRetinal ganglion cellsRegeneration-associated genesShort hairpin RNAIL-22Neural repairCentral nervous system traumaNeurological deficits persistNervous system traumaNerve crushAxonal damageAxonal regenerationGanglion cellsSystem traumaInflammatory responseCNS regenerationDeficits persistAxonal growthHairpin RNAConcurrent activationTranscription 3Cell-autonomous factorsKinase pathwaySignal transducerRepairPhotoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina
Pottackal J, Walsh HL, Rahmani P, Zhang K, Justice NJ, Demb JB. Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina. Journal Of Neuroscience 2021, 41: 1489-1504. PMID: 33397711, PMCID: PMC7896016, DOI: 10.1523/jneurosci.0674-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAmacrine CellsAnimalsCorticotropin-Releasing HormoneElectrophysiological PhenomenaExcitatory Postsynaptic PotentialsFemalegamma-Aminobutyric AcidGap JunctionsMaleMiceMice, Inbred C57BLNeural InhibitionNeuronsOptogeneticsPhotoreceptor Cells, VertebrateRetinaRetinal Cone Photoreceptor CellsRetinal Ganglion CellsRetinal Rod Photoreceptor CellsRod OpsinsSynapsesConceptsGap junction-mediated electrical synapsesAmacrine cellsElectrical synapsesIpRGC activityGanglion cellsRetinal interneuronsRetinal circuitsPhotosensitive retinal ganglion cellsGABAergic amacrine cellsRetinal ganglion cellsWhole-cell recordingsSpecific RGC typesAbsence of rodsIpRGC typesRGC typesPharmacological blockadeRetinal neuronsMelanopsin expressionMature retinaMouse retinaSynaptic circuitsNeuronal circuitsInterneuronsOptogenetic stimulationLocal inhibition
2020
Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry
Pottackal J, Singer JH, Demb JB. Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry. Frontiers In Cellular Neuroscience 2020, 14: 604163. PMID: 33324168, PMCID: PMC7726240, DOI: 10.3389/fncel.2020.604163.Peer-Reviewed Original ResearchDirection-selective ganglion cellsStarburst amacrine cellsFast cholinergic transmissionGABAergic inhibitionCholinergic transmissionGABAergic transmissionCholinergic excitationPostsynaptic currentsSynaptic mechanismsConventional synaptic transmissionReceptoral mechanismsReceptor blockadeAmacrine cellsGanglion cellsRetinal circuitryParacrine natureSynaptic transmissionConventional synapsesMammalian retinaMouse retinaParacrine transmissionParacrine modeDirection selectivityDistinct temporal propertiesReceptor kineticsConnectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision
Park SJ, Lieberman EE, Ke JB, Rho N, Ghorbani P, Rahmani P, Jun NY, Lee HL, Kim IJ, Briggman KL, Demb JB, Singer JH. Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision. ELife 2020, 9: e56077. PMID: 32412412, PMCID: PMC7228767, DOI: 10.7554/elife.56077.Peer-Reviewed Original ResearchConceptsAII amacrine cellsProjection neuronsSingle interneuron typeConnectomic analysisBipolar cell pathwaysNovel neural circuitGABAergic cellsAmacrine cellsCentral neuronsGanglion cellsSynaptic layersRetinal circuitsInterneuron typesSurround inhibitionMouse retinaNight visionON responseExcitatory centerOptogenetic analysesNeural circuitsInhibitory surroundCell pathwaysRod photoreceptorsReceptive fieldsRb pathwayRetinal innervation tunes circuits that drive nonphotic entrainment to food
Fernandez DC, Komal R, Langel J, Ma J, Duy PQ, Penzo MA, Zhao H, Hattar S. Retinal innervation tunes circuits that drive nonphotic entrainment to food. Nature 2020, 581: 194-198. PMID: 32404998, PMCID: PMC7291822, DOI: 10.1038/s41586-020-2204-1.Peer-Reviewed Original ResearchConceptsTime-restricted feedingEarly postnatal stagesPostnatal stagesAdult miceIntergeniculate leafletPhotosensitive retinal ganglion cellsRetinal ganglion cellsEarly postnatal periodFood anticipatory activityIGL neuronsGanglion cellsPostnatal periodRetinal inputIpRGCsAcute inhibitionCentral circadian pacemakerPhotic informationTime cuesMajor time cueSuprachiasmatic nucleusInnervationNonphotic cuesMiceNeuronsNonphotic entrainmentA retinal circuit for the suppressed-by-contrast receptive field of a polyaxonal amacrine cell
Jia Y, Lee S, Zhuo Y, Zhou ZJ. A retinal circuit for the suppressed-by-contrast receptive field of a polyaxonal amacrine cell. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 9577-9583. PMID: 32273387, PMCID: PMC7196907, DOI: 10.1073/pnas.1913417117.Peer-Reviewed Original ResearchConceptsPolyaxonal amacrine cellsAmacrine cellsGanglion cellsReceptive fieldsRetinal output neuronsTrigger featuresVGluT3 cellsRetinal activityCell dendritesRetinal circuitsLocal controlIntricate circuitryDownstream circuitsOutput neuronsDifferent subpopulationsRetinaDifferential connectivityDistal tipForm of crosstalkCellsDiverse populationsVisual processingCritical roleGlycinergicAmacrine
2019
TRPC5 regulates axonal outgrowth in developing retinal ganglion cells
Oda M, Yamamoto H, Matsumoto H, Ishizaki Y, Shibasaki K. TRPC5 regulates axonal outgrowth in developing retinal ganglion cells. Laboratory Investigation 2019, 100: 297-310. PMID: 31844148, DOI: 10.1038/s41374-019-0347-1.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cell layerRetinal ganglion cell axon outgrowthTRPC5 expressionDepletion of intracellular calcium storesAmacrine cellsExcessive Ca<sup>2+</sup> entryDeath of retinal ganglion cellsExpression of TRPC5Ganglion cellsAxonal outgrowthIntracellular calcium storesMuller glial cellsNitric oxideMature retinal ganglion cellsRetinal cell typesIn situ hybridizationCentral nervous systemTRPC5 activityCalcium storesTRPC5Characteristic cell morphologyMouse retinaGlial cellsHippocampal neurons
2018
Melanopsin Shows Its (Contrast-)Sensitive Side
Pottackal J, Demb JB. Melanopsin Shows Its (Contrast-)Sensitive Side. Neuron 2018, 99: 630-632. PMID: 30138585, DOI: 10.1016/j.neuron.2018.08.007.Peer-Reviewed Original ResearchA Fine-Scale Functional Logic to Convergence from Retina to Thalamus
Liang L, Fratzl A, Goldey G, Ramesh RN, Sugden AU, Morgan JL, Chen C, Andermann ML. A Fine-Scale Functional Logic to Convergence from Retina to Thalamus. Cell 2018, 173: 1343-1355.e24. PMID: 29856953, PMCID: PMC6003778, DOI: 10.1016/j.cell.2018.04.041.Peer-Reviewed Original ResearchConceptsAxonal boutonsRetinal ganglion cellsTwo-photon calciumImage-forming visionClusters of boutonsVisual thalamusGanglion cellsRetinal axonsBouton clustersThalamusMouse thalamusIndividual axonsDifferent axonsFeature selectivityBoutonsFine-scale organizationAxonsDendritic domainsUltrastructural analysisRetinaConvergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry
Park SJH, Pottackal J, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB. Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry. Journal Of Neuroscience 2018, 38: 3753-3766. PMID: 29572434, PMCID: PMC5895998, DOI: 10.1523/jneurosci.2518-17.2018.Peer-Reviewed Original ResearchConceptsAlpha ganglion cellsGanglion cell typesAmacrine cellsGanglion cellsCRH cellsAlpha cellsGABAergic synapsesInhibitory interneuronsExcitation/inhibition balanceCorticotropin-releasing hormoneCre transgenic miceFire action potentialsTonic excitatory driveCell typesBalance of excitationGABA releaseExcitatory circuitsRetinal circuitryExcitatory driveInhibition balanceInhibitory inputsMammalian retinaMouse retinaAction potentialsOptogenetic analyses
2017
Selective synaptic connections in the retinal pathway for night vision
Beaudoin DL, Kupershtok M, Demb JB. Selective synaptic connections in the retinal pathway for night vision. The Journal Of Comparative Neurology 2017, 527: 117-132. PMID: 28856684, PMCID: PMC5832573, DOI: 10.1002/cne.24313.Peer-Reviewed Original ResearchConceptsAII amacrine cellsRetinal ganglion cellsAmacrine cellsRGC typesBipolar terminalsSynaptic connectionsCertain retinal ganglion cellsConnected retinal ganglion cellsIonotropic glutamate receptor antagonistsOFF alpha cellsGlutamate receptor antagonistsInner plexiform layerBipolar cell terminalsSelective synaptic connectionsBipolar cell activityOFF alphaRetinal connectionsRetinal pathwaysPlexiform layerReceptor antagonistDirect synapsesGanglion cellsGlycinergic synapsesInhibitory currentsMammalian retina
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