2025
DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress
Alim S, Cheppali S, Pawar S, Swamy M. DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress. Biochimica Et Biophysica Acta (BBA) - Proteins And Proteomics 2025, 1873: 141064. PMID: 39956303, DOI: 10.1016/j.bbapap.2025.141064.Peer-Reviewed Original ResearchConceptsChaperone-like activitySeminal plasmaFibronectin type IITetramer to monomersSperm capacitationSurface hydrophobicityMolecular chaperonesClient proteinsHeat shock proteinsBiophysical studiesAlcohol dehydrogenaseOxidative stressPhysiological ligandsShock proteinsProteinHead group moietySHspsBinding of phosphorylcholineCholine phospholipidsBindingFibronectinDehydrogenaseChaperoneSpermMammals
2021
Purification, molecular characterization and ligand binding properties of the major donkey seminal plasma protein DSP-1
Alim S, Cheppali S, Laitaoja M, Talluri T, Jänis J, Swamy M. Purification, molecular characterization and ligand binding properties of the major donkey seminal plasma protein DSP-1. International Journal Of Biological Macromolecules 2021, 194: 213-222. PMID: 34863837, DOI: 10.1016/j.ijbiomac.2021.11.177.Peer-Reviewed Original ResearchConceptsSperm plasma membraneSeminal plasma proteinsFibronectin type IIAmino acid sequenceIntrinsic fluorescence titrationBind to phosphorylcholineHSP-1/2PDC-109Family proteinsAcid sequenceCholine phospholipidsLigand binding propertiesEquus hemionusMultiple acetylationsSeminal plasmaPlasma membraneMolecular characterizationMammalian speciesMembrane perturbationProteinHigh-resolution LC-MS analysisProtein 1Head group moietyBinding propertiesCell membrane
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