2025
Reframing the paradigm- rethinking placental and fetal immunity
Konnikova L. Reframing the paradigm- rethinking placental and fetal immunity. Placenta 2025 PMID: 40425428, DOI: 10.1016/j.placenta.2025.05.011.Peer-Reviewed Original ResearchPreterm birthMemory T cellsFetal immunityPreterm laborT cellsImmune cellsImmune developmentImmune systemNeonatal immune cellsReducing preterm laborFetal immune systemFetal immune developmentWeeks of gestationFetal immune responseMaternal tolerancePlacental immunityFetal organsCord bloodImmune environmentInfant bloodNeonatal healthImmunological issuesNeonatal protectionPrevent complicationsImmune responseInvestigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery
Lynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, PMCID: PMC11972154, DOI: 10.1016/j.biomaterials.2025.123238.Peer-Reviewed Original ResearchAmniotic fluidProtein corona formationProtein coronaIntra-amniotic deliveryNP delivery systemPEGylated nanoparticlesSurface polyethylene glycolPoly(lactic-co-glycolic acidProtein corona compositionLung cells in vitroCorona formationPLA-PEG nanoparticlesNon-PEGylated nanoparticlesCells in vitroLevels of albuminFetal bowelFetal lungFetal organsNP biodistributionPoly(lactic-acidDense brush conformationCorona compositionPolyvinyl alcoholBiodistribution profileCellular association
2022
Immune landscape of human placental villi using single-cell analysis
Toothaker JM, Olaloye O, McCourt BT, McCourt CC, Silva TN, Case RM, Liu P, Yimlamai D, Tseng G, Konnikova L. Immune landscape of human placental villi using single-cell analysis. Development 2022, 149 PMID: 35050308, PMCID: PMC8935213, DOI: 10.1242/dev.200013.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAntigens, Differentiation, MyelomonocyticB7-H1 AntigenB-LymphocytesChorionic VilliFemaleFetusFlow CytometryHLA-DR AntigensHumansKiller Cells, NaturalLeukocyte Common AntigensLymphocyte ActivationMacrophagesMemory T CellsPlacentaPregnancyPregnancy Trimester, SecondReceptors, Cell SurfaceReceptors, ChemokineSingle-Cell AnalysisT-LymphocytesConceptsT cellsHuman placental villiPlacental villiImmune systemFetal immune systemMaternal immune systemFetal immune cellsAdult T-cellT cell receptor stimulationCell receptor stimulationHealthy pregnancyImmune landscapeMemory phenotypeImmune cellsFetal organsEnhanced proliferative capacityReceptor stimulationMultiple subtypesPV tissueComplex immune systemImaging modalitiesMass cytometryProliferative capacityMaternal mechanismsRecent reports
2008
Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma
Kim J, McNiff JM. Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma. Modern Pathology 2008, 21: 764-769. PMID: 18425079, DOI: 10.1038/modpathol.2008.61.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaCell carcinomaPoor prognosisInhibition of apoptosisCutaneous Merkel cell carcinomaMedian patient ageAggressive clinical courseExpression of survivinNuclear staining patternClinical coursePatient ageNormal human tissuesPrimary lesionAggressive malignancyFemale ratioClinical managementDifferent human cancersFetal organsStrong immunoreactivityCarcinomaNuclear expressionSurvivin expressionStaining patternExact regulatory mechanismNuclear subcellular localization
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