2025
Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery
Lynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, PMCID: PMC11972154, DOI: 10.1016/j.biomaterials.2025.123238.Peer-Reviewed Original ResearchAmniotic fluidProtein corona formationProtein coronaIntra-amniotic deliveryNP delivery systemPEGylated nanoparticlesSurface polyethylene glycolPoly(lactic-co-glycolic acidProtein corona compositionLung cells in vitroCorona formationPLA-PEG nanoparticlesNon-PEGylated nanoparticlesCells in vitroLevels of albuminFetal bowelFetal lungFetal organsNP biodistributionPoly(lactic-acidDense brush conformationCorona compositionPolyvinyl alcoholBiodistribution profileCellular association
2021
Nanoparticles for delivery of agents to fetal lungs
Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Nanoparticles for delivery of agents to fetal lungs. Acta Biomaterialia 2021, 123: 346-353. PMID: 33484911, PMCID: PMC7962939, DOI: 10.1016/j.actbio.2021.01.024.Peer-Reviewed Original ResearchConceptsFetal lungCellular uptakeIntra-amniotic routeRoute of deliveryCongenital lung diseaseDelivery of agentsIntra-amniotic deliveryRelative cellular uptakeNanoparticlesFetal treatmentDiaphragmatic herniaLung diseaseFetal therapyLung tissueFetal miceIntravenous deliveryCystic fibrosisLungLung therapyInterventional technologiesTherapeutic agentsEndothelial cellsCell populationsEffective targetingTherapy
2000
Expression of Thyroid Transcription Factor-1 in Congenital Cystic Adenomatoid Malformation of the Lung
Morotti R, Gutierrez M, Askin F, Profitt S, Wert S, Whitsett J, Greco M. Expression of Thyroid Transcription Factor-1 in Congenital Cystic Adenomatoid Malformation of the Lung. Pediatric And Developmental Pathology 2000, 3: 455-461. PMID: 10890930, DOI: 10.1007/s100240010092.Peer-Reviewed Original ResearchConceptsCongenital cystic adenomatoid malformationCCAM type 1TTF-1 expressionCystic adenomatoid malformationThyroid transcription factor-1Gestational ageTTF-1Type 1Adenomatoid malformationTranscription factor 1Fetal lungAlveolar cell markersBasal cellsEpithelial cellsWeeks gestational ageTTF-1 stainingType 4Factor 1Bronchiolar basal cellsDistal air spacesAlveolar type II cellsType I cellsEarly lung developmentType II cellsCCAM casesGlucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung
Rooney S. Glucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung. Contemporary Endocrinology 2000, 91-104. DOI: 10.1007/978-1-59259-014-8_5.Peer-Reviewed Original Research
1999
Congenital cystic adenomatoid malformation of the lung (CCAM): Evaluation of the cellular components
Morotti R, Cangiarella J, Gutierrez M, Jagirdar J, Askin F, Singh G, Profitt S, Wert S, Whitsett J, Greco M. Congenital cystic adenomatoid malformation of the lung (CCAM): Evaluation of the cellular components. Human Pathology 1999, 30: 618-625. PMID: 10374767, DOI: 10.1016/s0046-8177(99)90084-9.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NeoplasmCD5 AntigensCystic Adenomatoid Malformation of Lung, CongenitalFetal DiseasesFetusGastrin-Releasing PeptideGlycoproteinsHumansHyaluronan ReceptorsNeoplasm ProteinsPeptidesProtein PrecursorsProteolipidsPulmonary Surfactant-Associated Protein CPulmonary SurfactantsSurface-Active AgentsConceptsCongenital cystic adenomatoid malformationCell-cell interactionsCystic adenomatoid malformationLung developmentCellular compositionAdenomatoid malformationProtein precursorCellular componentsNormal lung developmentPseudoglandular stageCCAM type 1Rare congenital lesionsSaccular stageNeuroendocrine cellsCell-associated antigensSurfactant proteinsEpithelial-lined cystsAdhesion moleculesCongenital lesionsCytodifferentiationImmunohistochemical stainsClara cellsFetal lungTracheobronchial treeMajor subtypes
1995
Lung epithelial Na channel subunits are differentially regulated during development and by steroids
Tchepichev S, Ueda J, Canessa C, Rossier B, O'Brodovich H. Lung epithelial Na channel subunits are differentially regulated during development and by steroids. American Journal Of Physiology 1995, 269: c805-c812. PMID: 7573414, DOI: 10.1152/ajpcell.1995.269.3.c805.Peer-Reviewed Original ResearchConceptsThyroid-releasing hormoneDays gestationFirst weekGamma-rENaC mRNANormal rat fetusesAlpha-rENaCMRNA levelsNa channelsNormal rat pupsEpithelial Na channelLate fetal gestationExpression of alphaCorticosteroid therapyCorticosteroid resistanceLung's abilityPregnant ratsRat pupsAdult ratsFetal lungRat fetusesPostnatal patternGlucocorticosteroid levelsFetal gestationGestationExpression correlates
1993
Expression of the epithelial Na+ channel in the developing rat lung
O'Brodovich H, Canessa C, Ueda J, Rafii B, Rossier B, Edelson J. Expression of the epithelial Na+ channel in the developing rat lung. American Journal Of Physiology 1993, 265: c491-c496. PMID: 7690185, DOI: 10.1152/ajpcell.1993.265.2.c491.Peer-Reviewed Original ResearchConceptsFetal lungAlveolar epitheliumRat lungAdult lungThyroid-releasing hormoneRat colonic epitheliumAlpha-rENaCWhole rat lungRat whole kidneyCombined administrationPregnant ratsImmature lungLung alphaAlveolar spaceColonic epitheliumLower mRNA levelsWhole kidneyLungSaccular stageLung developmentAdult alveolar epitheliumPrimary culturesDays GAEpitheliumMRNA levels
1989
Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis
Gross I, Wilson C, Floros J, Dynia D. Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis. Pediatric Research 1989, 25: 239-244. PMID: 2704589, DOI: 10.1203/00006450-198903000-00004.Peer-Reviewed Original ResearchConceptsRU 486Lung tissueGlucocorticoid agonist activityRat lung phospholipidsAntagonist RU 486Steroid antagonist RU 486Surfactant-associated protein AFetal rat lungGlucocorticoid antagonistSurfactant associated proteinsLung phospholipidsSurfactant-associated proteinsFetal lungRat lungSurfactant productionComponents of surfactantSignificant increaseGlucocorticoidsLungControl explantsSpecific cytoplasmicPhosphatidylcholine synthesisSame extentPhospholipid productionTissue
1984
DO EGF AND GLUCOCORTICOIDS ACT AT THE SAME METABOLIC SITES IN FETAL RAT LUNG?
Gross I, Dynia D. DO EGF AND GLUCOCORTICOIDS ACT AT THE SAME METABOLIC SITES IN FETAL RAT LUNG? Pediatric Research 1984, 18: 392-392. DOI: 10.1203/00006450-198404001-01797.Peer-Reviewed Original ResearchFetal rat lungCholine incorporationEffect of EGFRat lungFetal lung maturationEffect of DexDose-dependent fashionMetabolic sitesGestational ageLung maturationOrgan culture systemFetal lungGlucocorticoids actSerum-free organ culture systemMaximal effectDistribution of radioactivityThymidine incorporationMouse skinLungDependent fashionBiochemical developmentPhosphatidylglycerol fractionT3T4 actionEGF
1983
Fetal rat lung maturation: initiation and modulation
Gross I, Wilson C. Fetal rat lung maturation: initiation and modulation. Journal Of Applied Physiology 1983, 55: 1725-1732. PMID: 6662763, DOI: 10.1152/jappl.1983.55.6.1725.Peer-Reviewed Original ResearchConceptsFetal lung maturationGestational ageLung maturationCholine incorporationEquivalent gestational ageFetal rat lungGlucocorticoid bindingDays gestationLung tissueFetal lungRat lungBiochemical markersLung developmentMorphological maturationDSPC contentMesenchymal tissueMaturational processesMarked increaseHormoneSimilar increaseLungLate modulationPhosphatidylcholine synthesisAgeMaturation
1982
Fetal lung in organ culture. IV. Supra-additive hormone interactions
Gross I, Wilson C. Fetal lung in organ culture. IV. Supra-additive hormone interactions. Journal Of Applied Physiology 1982, 52: 1420-1425. PMID: 6286561, DOI: 10.1152/jappl.1982.52.6.1420.Peer-Reviewed Original ResearchConceptsFetal lung maturationLung maturationSupra-additive interactionOrgan cultureCombination of dexamethasoneRate of incorporationFetal rat lungVivo animal studiesHormone administrationFetal lungAnimal studiesRat lungSupra-additive stimulationThyroid hormonesNM dexamethasoneDexamethasone concentrationsMaximal stimulationLungDexamethasoneNM triiodothyroninePulmonary surfactantSignificant increaseStimulationPrecursor incorporationCyclic monophosphate
1980
Fetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. Fetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines. Journal Of Applied Physiology 1980, 48: 872-877. PMID: 7451297, DOI: 10.1152/jappl.1980.48.5.872.Peer-Reviewed Original ResearchConceptsFetal lungComparison of dexamethasoneLung glycogen contentSurfactant-associated phospholipidsFetal rat lungPercentage of radioactivityRat lungAminophyllineCholine-containing phospholipidsThyroxineGlycogen contentCholine incorporationLungCaffeine treatmentSignificant decreaseOrgan cultureRate of incorporationSignificant increaseLysolecithin acyltransferaseExposure of explantsCholinephosphate cytidylyltransferaseDexamethasoneDifferent effectsMembrane phospholipidsMethylxanthines
1979
The influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. The influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen. Biochimica Et Biophysica Acta 1979, 575: 375-383. PMID: 518894, DOI: 10.1016/0005-2760(79)90106-1.Peer-Reviewed Original ResearchConceptsFetal rat lungPercentage of radioactivityEstrogen actsFetal lungRat lungPhospholipid fractionInfluence of hormonesProtein/DNA ratioEstrogen treatmentIncorporation of cholineLungGlycogen contentTotal phospholipidsOrgan cultureSignificant stimulationPulmonary surfactantBiochemical developmentIndividual phospholipidsPhosphatidylcholine synthesisSignificant changesPhospholipid synthesisPhospholipidsAbundant phospholipidDNA ratioRadioactivityThe Hormonal Regulation of Fetal Lung Maturation
Gross I. The Hormonal Regulation of Fetal Lung Maturation. Clinics In Perinatology 1979, 6: 377-395. PMID: 230006, DOI: 10.1016/s0095-5108(18)31155-2.ChaptersEffects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung
Rooney S, Gobran L, Marino P, Maniscalco W, Gross I. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung. Biochimica Et Biophysica Acta 1979, 572: 64-76. PMID: 216408, DOI: 10.1016/0005-2760(79)90200-5.Peer-Reviewed Original ResearchConceptsLung lavageFetal lung lavageFetal lung slicesAdministration of betamethasoneEffect of betamethasoneFetal lung maturationFetal rabbit lungPhosphatidylcholine/sphingomyelin ratioLung glycogenBetamethasone administrationLung maturationPregnant rabbitsDays gestationFetal lungLung slicesRabbit lungsStress-induced accelerationDirect administrationSphingomyelin ratioSurfactant phospholipidsBetamethasoneAdministrationRate of incorporationSurfactant productionLavage
1978
Development of glycogen and phospholipid metabolism in fetal and newborn rat lung
Maniscalco W, Wilson C, Gross I, Gobran L, Rooney S, Warshaw J. Development of glycogen and phospholipid metabolism in fetal and newborn rat lung. Biochimica Et Biophysica Acta 1978, 530: 333-346. PMID: 100141, DOI: 10.1016/0005-2760(78)90153-4.Peer-Reviewed Original ResearchConceptsNewborn rat lungGlycogen phosphorylase activityFetal lungRat lungGlycogen concentrationFetal lung glycogenFirst postnatal dayPhosphorylase activityTotal glycogen synthaseTotal glycogen phosphorylase activityMajor metabolic substratesLung glycogenPhosphatidylcholine synthesisGlycogen synthase activityIncorporation of cholinePostnatal dayGlycogen depletionDay 19LungGestationDay 20Adult lungMammalian fetusGlycogen contentTotal phospholipids
1977
INSULIN DELAYS THE MORPHOLOGIC MATURATION OF FETAL RAT LUNG IN VITRO
Gross I, Walker Smith G, Warshaw J. INSULIN DELAYS THE MORPHOLOGIC MATURATION OF FETAL RAT LUNG IN VITRO. Pediatric Research 1977, 11: 515-515. DOI: 10.1203/00006450-197704000-00871.Peer-Reviewed Original ResearchAlveolar lining cellsLining cellsFetal rat lungAlveolar spaceLamellar bodiesRat lungGlycogen contentLevels of insulinIncidence of RDSInfluence of insulinControl culturesF12 mediumDiabetic mothersLung maturationFetal lungInsulinMorphologic maturationInterstitial tissueLungOrgan cultureGlycogen synthesisInterstitial mesenchymeContinued maturationMorphologic developmentCellsAN ORGAN CULTURE MODEL FOR THE STUDY OF FETAL LUNG MATURATION
Gross I, Czaika M, Walker Smith G, Warahaw J. AN ORGAN CULTURE MODEL FOR THE STUDY OF FETAL LUNG MATURATION. Pediatric Research 1977, 11: 406-406. DOI: 10.1203/00006450-197704000-00220.Peer-Reviewed Original ResearchOrgan culture modelLate-gestation fetal rat lungAlveolar lining cellsFetal lung maturationFresh lung tissueShort-term organ cultureFetal rat lungCulture modelDay fetal ratsLung maturationCentral necrosisLung tissueFetal lungFetal ratsLining cellsHormonal influencesBiochemical findingsRat lungLung developmentStromal tissueTissue chopperDay fetusesMorphologic maturationMorphological maturationGlycogen content
1976
Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis
Rooney S, Gobran L, Gross I, Wai-Lee T, Nardone L, Motoyama E. Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis. Biochimica Et Biophysica Acta 1976, 450: 121-130. PMID: 186118, DOI: 10.1016/0005-2760(76)90083-7.Peer-Reviewed Original ResearchMeSH Keywords1-Acylglycerophosphocholine O-AcyltransferaseAnimalsCholine KinaseCytidine Diphosphate CholineDiacylglycerol CholinephosphotransferaseFatty AcidsFemaleFetusGestational AgeGlycerolHydrocortisoneLungNucleotidyltransferasesPhosphatidylcholinesPhospholipidsPregnancyPulmonary SurfactantsRabbitsConceptsLung lavageCortisol administrationDays gestationFetal rabbitsUntreated fetusesLung phospholipid contentGreater gestational ageSaline-injected controlsLysolecithin acyltransferasePhospholipid contentGestational ageIntrauterine injectionLung tissueSaline injectionFetal lungMaturational effectsGestationFetusesLavageMajor surface-active componentAdministrationCorticosteroidsCholinephosphate cytidylyltransferaseSynthesis of phosphatidylcholineHormone
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