2025
Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery
Lynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, PMCID: PMC11972154, DOI: 10.1016/j.biomaterials.2025.123238.Peer-Reviewed Original ResearchAmniotic fluidProtein corona formationProtein coronaIntra-amniotic deliveryNP delivery systemPEGylated nanoparticlesSurface polyethylene glycolPoly(lactic-co-glycolic acidProtein corona compositionLung cells in vitroCorona formationPLA-PEG nanoparticlesNon-PEGylated nanoparticlesCells in vitroLevels of albuminFetal bowelFetal lungFetal organsNP biodistributionPoly(lactic-acidDense brush conformationCorona compositionPolyvinyl alcoholBiodistribution profileCellular association
2018
21 Omphalocele
Campbell K, Copel J. 21 Omphalocele. 2018, 84-91.e1. DOI: 10.1016/b978-0-323-44548-1.00021-8.ChaptersMaternal serum alpha-fetoproteinUmbilical cordSilastic spring-loaded siloKaryotype abnormalitiesAdditional fetal anomaliesAnterior abdominal massSpring-loaded siloUmbilical cord cystsOverall survival rateSerum alpha-fetoproteinCases of omphaloceleIncidence of omphalocelePentalogy of CantrellLimb-body wall complexFetal karyotype abnormalitiesCord cystsFetal bowelAbdominal massCord insertionUrachal abnormalitiesBladder exstrophyPostnatal therapyPrimary closureReproductive ageFetal anomalies20 Gastroschisis
Campbell K, Copel J. 20 Gastroschisis. 2018, 78-84.e1. DOI: 10.1016/b978-0-323-44548-1.00020-6.ChaptersFetal bowelAmniotic cavityLong-term total parenteral nutritionSilastic spring-loaded siloAlpha fetal protein levelCharacteristic US appearanceSpring-loaded siloUmbilical cord cystsOverall survival rateSerum alpha fetal protein levelShort gut syndromeLong-term complicationsTotal parenteral nutritionCases of gastroschisisPrenatal detection ratePentalogy of CantrellAdditional fetal malformationsLimb-body wall complexBowel dysmotilityCord cystsParenteral nutritionGut syndromeLiver failureUrachal abnormalitiesBladder exstrophy
1998
An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers
Bahado-Singh R, Deren O, Oz U, Tan A, Hunter D, Copel J, Mahoney M. An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers. American Journal Of Obstetrics And Gynecology 1998, 179: 514-519. PMID: 9731862, DOI: 10.1016/s0002-9378(98)70388-6.Peer-Reviewed Original ResearchConceptsHyperechoic fetal bowelMaternal ageDown syndromeFetal bowelUltrasonographic parametersScreen-positive rateSignificant independent predictorsAge-related riskDown syndrome riskIndividual oddsLikelihood ratioPositive predictive valueHypoplastic fifth digitDigit hypoplasiaWeeks' gestationIndependent predictorsNormal medianIndividual Down syndrome oddsSingleton fetusesSyndrome riskUltrasonographic markersSerum screeningGenetic amniocentesisHigh riskNuchal thickening
1994
Hyperechoic fetal bowel: The perinatal consequences
Bahado‐Singh R, Morotti R, Copel I, Mahoney M. Hyperechoic fetal bowel: The perinatal consequences. Prenatal Diagnosis 1994, 14: 981-987. PMID: 7899272, DOI: 10.1002/pd.1970141014.Peer-Reviewed Original ResearchConceptsCystic fibrosisFetal populationHyperechoic fetal bowelRate of complicationsIntrauterine growth retardationPerinatal consequencesFetal bowelFetal demiseAdverse outcomesBowel echogenicityHigh prevalencePrenatal sonogramsPriori riskGrowth retardationFibrosisWarrants investigationComplicationsChromosome abnormalitiesHigh rateFetusesRiskRisk figuresAneuploidyPopulationPrematurity
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