2025
Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Wing A, Jeffery E, Church C, Goodell J, Saavedra-Peña R, Saha M, Holtrup B, Voisin M, Alavi N, Floody M, Wang Z, Zapadka T, Garabedian M, Varshney R, Rudolph M, Rodeheffer M. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Reports 2025, 44: 115527. PMID: 40208790, PMCID: PMC12073628, DOI: 10.1016/j.celrep.2025.115527.Peer-Reviewed Original ResearchAdipocyte precursor cellsDietary fatPlasma monounsaturated fatty acidsAssociated with human obesityHuman adipocyte precursor cellsMonounsaturated fatty acidsDietary fat compositionDietary screeningFatty acidsDietary fatty acidsHuman obesityAdipose expansionMetabolic healthObesity epidemicAkt2 signalingLXR activationPrecursor cellsAdipose biologyOleic acidHyperplasiaObesityAdipocyte hyperplasiaDietary oleic acidPhysiological regulationAdipogenesis
2018
APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality
Satizabal CL, Samieri C, Davis-Plourde KL, Voetsch B, Aparicio HJ, Pase MP, Romero JR, Helmer C, Vasan RS, Kase CS, Debette S, Beiser AS, Seshadri S. APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality. Stroke 2018, 49: 2822-2829. PMID: 30571417, PMCID: PMC6310220, DOI: 10.1161/strokeaha.118.022132.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseAPOE ε4 carriersRisk of strokeHeart diseaseSD unit increaseCause strokeIschemic strokeCause mortality eventsPlasma fatty acidsFatty acidsAPOE ε4 genotypeRandom-effects modelFatty acid levelsUnit increaseMeta-analysis resultsMetabolism of lipidsLinoleic acidCause mortalityMean agePotential confoundersCardiovascular healthRisk factorsAPOE genotypeCardiovascular diseaseDietary fat
2017
Age-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat
Damgaard M, Pærregaard S, Søgaard I, Agerholm M, Paulson J, Treebak J, Sina C, Holm J, Kristiansen K, Jensen B. Age-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat. The Journal Of Nutritional Biochemistry 2017, 54: 66-76. PMID: 29268121, DOI: 10.1016/j.jnutbio.2017.09.026.Peer-Reviewed Original ResearchConceptsGlucose homeostasisGut microbial alterationsGene amplicon sequencingInfluence of dietary fat sourceLow-fat dietAmplicon sequencingFatty acidsGut microbiotaResponse to insulinDietary fat sourceMicrobial alterationsAssessed glucose homeostasisMetabolic homeostasisDietary fatGlucose clearanceGlucose regulationLFD-fed miceFat sourcesHomeostasisFish oilGroups of miceInsulin tolerance testWeek 8 to weekSoybean oilSevere nonalcoholic steatohepatitis
2013
A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency
Tellez LA, Medina S, Han W, Ferreira JG, Licona-Limón P, Ren X, Lam TT, Schwartz GJ, de Araujo IE. A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency. Science 2013, 341: 800-802. PMID: 23950538, DOI: 10.1126/science.1239275.Peer-Reviewed Original ResearchConceptsDopamine deficiencyFed miceDietary fatExcess dietary fatBrain dopaminergic functionHigh fat intakeHigh-fat exposureGastrointestinal dysfunctionIntragastric feedingOral intakeDopaminergic functionDopamine releaseExcessive intakeIntakeMiceDeficiencyOleoylethanolamineLipid messengersPhysiological mechanismsFatMotivation deficitsLipid signalingReward sensitivityObesityDysfunction
2008
Reproducibility of single‐ and multi‐voxel 1H MRS measurements of intramyocellular lipid in overweight and lean subjects under conditions of controlled dietary calorie and fat intake
Shen W, Mao X, Wolper C, Heshka S, Dashnaw S, Hirsch J, Heymsfield SB, Shungu DC. Reproducibility of single‐ and multi‐voxel 1H MRS measurements of intramyocellular lipid in overweight and lean subjects under conditions of controlled dietary calorie and fat intake. NMR In Biomedicine 2008, 21: 498-506. PMID: 17955571, PMCID: PMC2892914, DOI: 10.1002/nbm.1218.Peer-Reviewed Original ResearchConceptsIntramyocellular lipidsLean subjectsSV-MRSTotal muscle creatineTibialis anterior muscleOverweight subjectsFat intakeDietary fatAnterior muscleCalorie intakeMuscle creatineFemale CaucasiansDietary caloriesDuplicate measuresMRS measurementsIntakeMRSISubjectsShorter scan timeTCRDaysOverweightLipidsCoefficient of variation
2001
Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria
Willett W, Stampfer M, Chu NF, Spiegelman D, Holmes M, Rimm E. Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria. American Journal Of Epidemiology 2001, 154: 1107-1112. PMID: 11744515, DOI: 10.1093/aje/154.12.1107.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersBody Mass IndexBody WeightCholesterol, HDLCohort StudiesCross-Sectional StudiesDiet SurveysDietary FatsDietary FiberDietary ProteinsEnergy IntakeExerciseFastingFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRegression AnalysisReproducibility of ResultsSmokingSurveys and QuestionnairesTriglyceridesConceptsTotal fat intakeFood frequency questionnaireFat intakeTriglyceride levelsFrequency questionnaireDietary fatSemiquantitative food frequency questionnaireHealth Professionals FollowBody mass indexHigh fat intakePlasma lipid levelsMetabolic studiesIntake of proteinCross-sectional analysisProfessionals FollowOverweight menMass indexInverse associationLipid levelsPhysical activityBlood specimensAlcohol consumptionSpecific biomarkersIntakeMultiple regression analysisTypes of dietary fat and breast cancer: A pooled analysis of cohort studies
Smith‐Warner S, Spiegelman D, Adami H, Beeson W, van den Brandt P, Folsom A, Fraser G, Freudenheim J, Goldbohm R, Graham S, Kushi L, Miller A, Rohan T, Speizer F, Toniolo P, Willett W, Wolk A, Zeleniuch‐Jacquotte A, Hunter D. Types of dietary fat and breast cancer: A pooled analysis of cohort studies. International Journal Of Cancer 2001, 92: 767-774. PMID: 11340585, DOI: 10.1002/1097-0215(20010601)92:5<767::aid-ijc1247>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsType of fatBreast cancer riskRelative riskCancer riskIncident invasive breast cancer casesStudy-specific relative risksInvasive breast cancer casesCarbohydrate consumptionVegetable fat intakePooled relative riskBreast cancer casesEquivalent energy intakeRandom-effects modelWeak positive associationCohort studyMenopausal statusFat intakeProspective studyPooled analysisDietary fatBreast cancerCancer casesPooled databaseEnergy intakeIntakeProspective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3
Cho E, Hung S, Willett W, Spiegelman D, Rimm E, Seddon J, Colditz G, Hankinson S. Prospective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 73: 209-218. PMID: 11157315, DOI: 10.1093/ajcn/73.2.209.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDTotal fat intakeFat intakeRelative riskHealth StudyPooled multivariate relative risksDiagnosis of AMDFish/wkModest inverse relationServings/moHealth Professionals FollowMultivariate relative riskNurses' Health StudyFood frequency questionnaireProfessionals FollowStudy of participantsProspective followVisual lossProspective studyLowest quintileDietary fatMacular degenerationHigh intakeLinolenic acid
1999
Dietary Fat and Coronary Heart Disease: A Comparison of Approaches for Adjusting for Total Energy Intake and Modeling Repeated Dietary Measurements
Hu F, Stampfer M, Rimm E, Ascherio A, Rosner B, Spiegelman D, Willett W. Dietary Fat and Coronary Heart Disease: A Comparison of Approaches for Adjusting for Total Energy Intake and Modeling Repeated Dietary Measurements. American Journal Of Epidemiology 1999, 149: 531-540. PMID: 10084242, DOI: 10.1093/oxfordjournals.aje.a009849.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseRisk of CHDTotal energy intakeNutrient density modelsBaseline dietHeart diseaseHigh intakeHealth StudyDietary measurementsEnergy intakeMultivariate nutrient density modelsPrevious cohort studiesNurses' Health StudyAssessment of dietEnergy adjustment methodCohort studyEnergy adjustmentFat intakeDietary fatRelative riskRecent dietDietary assessmentIntakeTrans fatsMultivariate model
1997
Current Dietary Practices and Stages of Change for Dietary Fat in Women
Krummel D, Humphries D, Rye S, Simon K. Current Dietary Practices and Stages of Change for Dietary Fat in Women. Journal Of The Academy Of Nutrition And Dietetics 1997, 97: a21. DOI: 10.1016/s0002-8223(97)00390-8.Peer-Reviewed Original ResearchLow-fat dietDietary fatStages of changeFat dietChronic diseasesCardiovascular diseaseNutrition interventionsPrimary care sitesSelf-rated healthCurrent dietary practicesWest Virginia womenNumber of barriersSample of womenDiet recallCare sitesRestaurant eatingHealthy dietDietary practicesFamily preferencesStaging algorithmWomenDiseaseActivity levelsDietTable analysisNon-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer
Hunter D, Spiegelman D, Adami H, van den Brandt P, Folsom A, Goldbohm R, Graham S, Howe G, Kushi L, Marshall J, Miller A, Speizer F, Willett W, Wolk A, Yaun S. Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer. Cancer Causes & Control 1997, 8: 49-56. PMID: 9051322, DOI: 10.1023/a:1018431104786.Peer-Reviewed Original ResearchConceptsBenign breast diseaseTotal fat intakeFat intakeBreast cancer riskRisk factorsBreast cancerBreast diseaseRelative riskCancer riskNon-dietary risk factorsEnergy-adjusted fat intakeMultivariate-adjusted riskFood frequency questionnaireDietary fat intakeAge-adjusted analysesCase-control studyNon-dietary factorsProspective studyMaternal historyLate menarcheHigher parityDietary fatFamily historyReproductive factorsEffect modifiers
1994
The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions
Goldin B, Woods M, Spiegelman D, Longcope C, Morrill‐LaBrode A, Dwyer J, Gualtieri L, Hertzmark E, Gorbach S. The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions. Cancer 1994, 74: 1125-1131. PMID: 8039147, DOI: 10.1002/1097-0142(19940801)74:3+<1125::aid-cncr2820741521>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsPremenopausal womenSerum concentrationsSex hormonesDietary fatEstrone sulfateSerum sex hormonesSerum estrogen concentrationsSignificant decreaseInitial control periodDietary fiberMetabolic kitchenFollicular phaseMenstrual cycleFree estradiolAmount of fatEstrogen concentrationsHigh fiberDietary conditionsControl periodEstradiolIndependent effectsWomenAndrostenedioneFatHormone
1992
Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up.
Willett WC, Hunter DJ, Stampfer MJ, Colditz G, Manson JE, Spiegelman D, Rosner B, Hennekens CH, Speizer FE. Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up. JAMA 1992, 268: 2037-44. PMID: 1328696, DOI: 10.1001/jama.268.15.2037.Peer-Reviewed Original ResearchConceptsTotal fat intakeBreast cancer incidenceFat intakeBreast cancerPostmenopausal womenCancer incidenceProtective effectHealth StudySelf-administered food frequency questionnaireEnergy intakePositive associationDietary fat increasesNurses' Health StudyProspective cohort studyFood frequency questionnaireTotal energy intakeMiddle-aged womenYears of ageDietary questionnaireCohort studyFrequency questionnaireIncident casesRisk factorsDietary fatCorresponding RRsDietary Fat and Fiber in Relation to Risk of Breast Cancer: An 8-Year Follow-up
Willett W, Hunter D, Stampfer M, Colditz G, Manson J, Spiegelman D, Rosner B, Hennekens C, Speizer F. Dietary Fat and Fiber in Relation to Risk of Breast Cancer: An 8-Year Follow-up. JAMA 1992, 268: 2037-2044. DOI: 10.1001/jama.1992.03490150089030.Peer-Reviewed Original ResearchTotal fat intakeBreast cancer incidenceFat intakeBreast cancerPostmenopausal womenCancer incidenceProtective effectHealth StudySelf-administered food frequency questionnaireEnergy intakePositive associationDietary fat increasesNurses' Health StudyProspective cohort studyFood frequency questionnaireTotal energy intakeMiddle-aged womenYears of ageDietary questionnaireCohort studyFrequency questionnaireIncident casesRisk factorsDietary fatCorresponding RRs
1990
CORRECTION OF LOGISTIC REGRESSION RELATIVE RISK ESTIMATES AND CONFIDENCE INTERVALS FOR MEASUREMENT ERROR: THE CASE OF MULTIPLE COVARIATES MEASURED WITH ERROR
ROSNER B, SPIEGELMAN D, WILLETT WC. CORRECTION OF LOGISTIC REGRESSION RELATIVE RISK ESTIMATES AND CONFIDENCE INTERVALS FOR MEASUREMENT ERROR: THE CASE OF MULTIPLE COVARIATES MEASURED WITH ERROR. American Journal Of Epidemiology 1990, 132: 734-745. PMID: 2403114, DOI: 10.1093/oxfordjournals.aje.a115715.Peer-Reviewed Original ResearchConceptsAge-adjusted relative riskRelative riskRisk factorsFat intakeMultiple logistic regression modelBreast cancer riskConfidence intervalsTrue risk factorRelative risk estimatesValidation studyLogistic regression modelsMultivariate linear regression modelRegression modelsAlcohol intakeProspective studyDietary fatBreast cancerCancer riskLogistic regressionRisk estimatesIntakeRiskSeparate validation studyContinuous variablesPositive association
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply