2025
Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure
Hubbell K, Rao V, Scherzer R, Shlipak M, Ivery‐Miranda J, Bansal N, Cox Z, Testani J, Estrella M. Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure. ESC Heart Failure 2025 PMID: 40504107, DOI: 10.1002/ehf2.15342.Peer-Reviewed Original ResearchAcute decompensated heart failureDecompensated heart failureDiuretic responseHeart failureHF rehospitalizationRisk of HF rehospitalizationBiomarker modelAssociated with poor outcomesAssociated with decreased riskAssociated with increased riskAssociated with cardiometabolic diseasesAssociated with mortalityAssociated with rehospitalizationDiuretic resistanceMedian ageResistance cohortClinical factorsPoor outcomeSociodemographic/lifestyle factorsPrognostic toolCombined biomarkersCardiometabolic diseasesPatientsAmbulatory settingMortality riskAssociation Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium
Lee S, Ahn C, Abe S, Rahman M, Islam M, Saito E, An S, Sawada N, Shu X, Koh W, Cai H, Hozawa A, Kanemura S, Nagata C, You S, Kang D, Kanehara R, Gao Y, Yuan J, Wen W, Sugawara Y, Wada K, Chen C, Yoo K, Ahsan H, Chia K, Shin A, Kim J, Lee J, Matsuo K, Rothman N, Qiao Y, Zheng W, Boffetta P, Inoue M, Park S. Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium. Journal Of Epidemiology 2025, 35: je20240362. PMID: 40368779, PMCID: PMC12162181, DOI: 10.2188/jea.je20240362.Peer-Reviewed Original ResearchAsia Cohort ConsortiumCardiovascular disease mortalityAll-causeHazard ratioCardiometabolic multimorbidityCohort ConsortiumPremature mortalityCardiovascular diseaseAge- and sex-adjusted hazard ratioSex-adjusted hazard ratioCardiometabolic diseasesRisk of premature mortalityCohort studyConfidence intervalsIndividual cardiometabolic diseasesProspective cohort studyBody mass indexHigh-risk conditionsPersonalized management strategiesAsian cohort studiesMultimorbiditySmoking statusIschemic heart diseaseMortality riskCox hazard regressionThe Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Mahabamunuge J, Sekula N, Lepore C, Kudrimoti M, Upadhyay A, Alshowaikh K, Li H, Seifer D, AlAshqar A. The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review. Biomedicines 2025, 13: 709. PMID: 40149685, PMCID: PMC11940587, DOI: 10.3390/biomedicines13030709.Peer-Reviewed Original ResearchPolycystic ovary syndromeType 2 diabetes mellitusCardiometabolic morbidityIncreased cardiovascular riskDevelopment of hypertensionCardiovascular risk factorsNarrative reviewPotential clinical implicationsAndrogen excessEndothelial dysfunctionCardiovascular riskClinical conditionsPredisposed individualsTherapeutic strategiesAdipokine secretionRisk factorsInsulin resistanceCardiometabolic diseasesCardiovascular diseaseClinical implicationsMorbidityMellitusSyndromeMolecular mechanismsDiseaseSuppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases
Rubinelli L, Manzo O, Sungho J, Del Gaudio I, Bareja R, Marino A, Palikhe S, Di Mauro V, Bucci M, Falcone D, Elemento O, Ersoy B, Diano S, Sasset L, Di Lorenzo A. Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases. Nature Communications 2025, 16: 1968. PMID: 40000621, PMCID: PMC11862206, DOI: 10.1038/s41467-025-56869-9.Peer-Reviewed Original ResearchConceptsNogo-BEndothelial dysfunctionHFD miceCardiometabolic diseasesSphingolipid signalingDevelopment of therapeutic strategiesBioactive sphingolipidsCeramide degradationSphingosine-1-phosphateHepatic glucose productionIn vivo evidenceEndothelial cellsEndothelial specific deletionCeramideBiosynthesisHigh-fat dietPathological implicationsSphingolipidsGlucose productionHFDIn vivoMale miceMetabolic dysfunctionTherapeutic strategiesMetabolic disorders
2024
A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program
Kember R, Rentsch C, Lynch J, Vujkovic M, Voight B, Justice A, Program M, Assimes T, Kranzler H. A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program. Alcohol Clinical And Experimental Research 2024, 48: 2256-2268. PMID: 39580711, PMCID: PMC11629435, DOI: 10.1111/acer.15445.Peer-Reviewed Original ResearchCoronary heart diseaseMR analysisMillion Veteran ProgramGenetic scoreAlcohol consumptionBody mass indexMendelian randomizationCardiometabolic diseasesVeteran ProgramAfrican AmericansAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) scoresEuropean AmericansHispanic AmericansAssociation of alcohol consumptionMultivariable MR analysisAssociated with CHD riskMendelian randomization studiesRisk of cardiometabolic diseasesAssociated with alcohol consumptionCardiometabolic disease riskIncidence of coronary heart diseaseObservational studyNested case-control studyReduced risk of cardiometabolic diseasesMulti-ancestry populationChildhood adversity, accelerated GrimAge, and associated health consequences
Harvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 47: 913-926. PMID: 38762606, PMCID: PMC11365810, DOI: 10.1007/s10865-024-00496-0.Peer-Reviewed Original ResearchBody mass indexChildhood Trauma QuestionnaireGrimAge accelerationEarly life stressChildhood adversityAssociated with higher body mass indexCross-sectional cohort of adultsMetabolic healthEffect of body mass indexHigher body mass indexPhysical health problemsLife stressCohort of adultsAssociated health consequencesEffects of early life stressMetabolic health effectsModerating effect of body mass indexChildhood Trauma Questionnaire subscalesCross-sectional cohortCardiometabolic healthAccelerated GrimAgeCardiometabolic diseasesMedical illnessHealth consequencesMass indexAccelerometer-Based Estimates of Physical Activity and Sedentary Time Among Samoan Adults.
Hawley N, Zarei P, Crouter S, Desai M, Pomer A, Rivara A, Naseri T, Reupena M, Viali S, Duckham R, McGarvey S. Accelerometer-Based Estimates of Physical Activity and Sedentary Time Among Samoan Adults. Journal Of Physical Activity And Health 2024, 21: 636-644. PMID: 38621669, DOI: 10.1123/jpah.2023-0590.Peer-Reviewed Original ResearchModerate to vigorous physical activityVigorous physical activityEstimates of physical activityPhysical activitySamoan adultsSedentary timeLight physical activityPhysical activity levelsAccelerometer-based devicesModifiable risk factorsClass II/III obesitySedentary activitiesWeight statusHealthy weightAdult SamoansParticipant characteristicsObesity-related diseasesCardiometabolic diseasesCensus regionActivity levelsGeneralized linear modelRural areasObesity-related cardiometabolic diseasesRisk factorsAdultsImpact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study
Jansana A, Auguste A, Kvaskoff M, Fournier A, Fontvieille E, Peruchet‐Noray L, Biessy C, Cordova R, Petersen K, Tjønneland A, Katzke V, Kaaks R, Ricceri F, Panico S, Contiero P, Sánchez M, Castilla J, Crous‐Bou M, Heath A, Aglago E, Weiderpass E, Gunter M, Ferrari P, Riboli E, Viallon V, Freisling H. Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study. Cancer Communications 2024, 44: 593-597. PMID: 38487965, PMCID: PMC11110950, DOI: 10.1002/cac2.12526.Peer-Reviewed Original ResearchSelection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Lennon N, Kottyan L, Kachulis C, Abul-Husn N, Arias J, Belbin G, Below J, Berndt S, Chung W, Cimino J, Clayton E, Connolly J, Crosslin D, Dikilitas O, Velez Edwards D, Feng Q, Fisher M, Freimuth R, Ge T, Glessner J, Gordon A, Patterson C, Hakonarson H, Harden M, Harr M, Hirschhorn J, Hoggart C, Hsu L, Irvin M, Jarvik G, Karlson E, Khan A, Khera A, Kiryluk K, Kullo I, Larkin K, Limdi N, Linder J, Loos R, Luo Y, Malolepsza E, Manolio T, Martin L, McCarthy L, McNally E, Meigs J, Mersha T, Mosley J, Musick A, Namjou B, Pai N, Pesce L, Peters U, Peterson J, Prows C, Puckelwartz M, Rehm H, Roden D, Rosenthal E, Rowley R, Sawicki K, Schaid D, Smit R, Smith J, Smoller J, Thomas M, Tiwari H, Toledo D, Vaitinadin N, Veenstra D, Walunas T, Wang Z, Wei W, Weng C, Wiesner G, Yin X, Kenny E. Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations. Nature Medicine 2024, 30: 480-487. PMID: 38374346, PMCID: PMC10878968, DOI: 10.1038/s41591-024-02796-z.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPredictive performance of polygenic risk scoresPerformance of polygenic risk scoresPolygenic risk score performanceRisk scoreGenetic diversity dataElectronic medical recordsDiverse US populationStrength of evidenceDiverse clinical settingsDiverse adultsUS populationHispanic populationCardiometabolic diseasesGenetic ancestryProgram cohortGenetic resultsMedical recordsDiverse populationsMedical actionClinical settingProvidersRisk assessmentScoresDiverse data
2023
SEQUENCE ANALYSIS OF CARDIOMETABOLIC MULTIMORBIDITY AND ASSOCIATION WITH SUBSEQUENT DEMENTIA
Nagel C, Allore H, Botoseneanu A, Kaye J, Newsom J, Bishop N, Quiñones A. SEQUENCE ANALYSIS OF CARDIOMETABOLIC MULTIMORBIDITY AND ASSOCIATION WITH SUBSEQUENT DEMENTIA. Innovation In Aging 2023, 7: 230-231. PMCID: PMC10736019, DOI: 10.1093/geroni/igad104.0758.Peer-Reviewed Original ResearchIncident cardiometabolic diseaseCardiometabolic multimorbidityCardiometabolic diseasesMyocardial infarctionSubsequent dementiaHeart diseaseSelf-reported diagnosisAging Trends StudyBaseline diseasePrior diseaseIncident diseaseNational HealthMultimorbidityMultimorbidity researchDiseaseCognitive healthBody mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies
Fontvieille E, Viallon V, Recalde M, Cordova R, Jansana A, Peruchet-Noray L, Lennon H, Heath A, Aune D, Christakoudi S, Katzke V, Kaaks R, Inan-Eroglu E, Schulze M, Mellemkjær L, Tjønneland A, Overvad K, Farràs M, Petrova D, Amiano P, Chirlaque M, Moreno-Iribas C, Tin Tin S, Masala G, Sieri S, Ricceri F, Panico S, May A, Monninkhof E, Weiderpass E, Gunter M, Ferrari P, Freisling H. Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies. BMC Medicine 2023, 21: 418. PMID: 37993940, PMCID: PMC10666332, DOI: 10.1186/s12916-023-03114-z.Peer-Reviewed Original ResearchConceptsRisk due to interactionObesity-related cancersRisk of obesity-related cancersBody mass indexHigher body mass indexCardiometabolic diseasesJoint associationsHazard ratioCancer riskIncidence of obesity-related cancersJoint association of body mass indexCardiovascular diseaseConfidence intervalsRisk of overall cancerExcess risk due to interactionAssociation of body mass indexSurrogate measure of adiposityUK Biobank prospective cohortCategories of overweight/obesityUK Biobank (UKBAdditive interactionMass indexCardiometabolic disease statusParticipant data meta-analysisCancer risk reductionBirth weight influences cardiac structure, function, and disease risk: evidence of a causal association
Ardissino M, Morley A, Slob E, Schuermans A, Rayes B, Raisi-Estabragh Z, de Marvao A, Burgess S, Rogne T, Honigberg M, Ng F. Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. European Heart Journal 2023, 45: 443-454. PMID: 37738114, PMCID: PMC10849320, DOI: 10.1093/eurheartj/ehad631.Peer-Reviewed Original ResearchLow birth weightAdverse intrauterine environmentCoronary artery diseaseBirth weightIntrauterine environmentCardiac structureArtery diseaseFoetal effectsCardiovascular disease prevention strategiesDisease riskAdverse cardiac structureCardiovascular disease riskCommon pregnancy complicationLower stroke volumeDisease prevention strategiesMendelian randomization studyBenjamini-Hochberg correctionPregnancy complicationsIschemic strokeHeart failureAtrial fibrillationCardiometabolic diseasesIntrauterine influencesStroke volumeCardiovascular diseaseDesign and methods of a translational, community-based, lifestyle weight management pilot intervention trial in breast cancer survivors with overweight or obesity
Haynam M, Chaplow Z, DeScenza V, Bowman J, Dispennette K, Zhang X, Kilar M, Hohn S, Fairman C, Lustberg M, Focht B. Design and methods of a translational, community-based, lifestyle weight management pilot intervention trial in breast cancer survivors with overweight or obesity. Contemporary Clinical Trials Communications 2023, 33: 101154. PMID: 37250507, PMCID: PMC10220259, DOI: 10.1016/j.conctc.2023.101154.Peer-Reviewed Original ResearchBreast cancer survivorsLifestyle weight management interventionsWeight management programWeight management interventionsPilot trialCancer survivorsPreliminary efficacyPilot intervention trialPatient-reported outcomesLifestyle behavior changeSignificant weight gainBreast cancer treatmentMode of deliveryCommunity-based intervention modelMulti-component interventionCommunity-based interventionsQuality of lifeTrial feasibilityDietary modificationCardiometabolic diseasesIntervention trialsCancer recurrenceEfficacy trialsOverweightWeight gainCardiometabolic disease and obesity patterns differentially predict acute kidney injury after total joint replacement: a retrospective analysis
Leis A, Mathis M, Kheterpal S, Zawistowski M, Mukherjee B, Pace N, O'Reilly-Shah V, Smith J, Karvonen-Gutierrez C. Cardiometabolic disease and obesity patterns differentially predict acute kidney injury after total joint replacement: a retrospective analysis. British Journal Of Anaesthesia 2023, 131: 37-46. PMID: 37188560, PMCID: PMC10308436, DOI: 10.1016/j.bja.2023.04.001.Peer-Reviewed Original ResearchConceptsOdds of acute kidney injuryAcute kidney injuryCardiometabolic diseasesNon-Hispanic blacksGroup of hospitalsKidney injuryCardiometabolic patternTotal joint arthroplasty complicationsObesity statusObesity patternsIncreased oddsDisease co-occurrenceIncreased odds of AKIRetrospective analysisRisk of postoperative acute kidney injuryLatent class analysisLatent classesPostoperative acute kidney injuryRisk of acute kidney injuryRisk factorsDifferential riskTotal joint replacementMetabolic syndromeObesityPostoperative AKI riskThe role of hepatokines in NAFLD
Stefan N, Schick F, Birkenfeld A, Häring H, White M. The role of hepatokines in NAFLD. Cell Metabolism 2023, 35: 236-252. PMID: 36754018, PMCID: PMC10157895, DOI: 10.1016/j.cmet.2023.01.006.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseNon-communicable diseasesInsulin resistanceVisceral obesityMajor non-communicable diseasesRole of hepatokinesFatty liver diseaseRole of fetuinVisceral adiposityFatty liverLiver diseaseCardiometabolic diseasesPathophysiological mechanismsOrgan crosstalkHepatokinesMain pathomechanismClinical practiceImportant causeDiseasePrecision medicineAdipokinesObesityMetabolismAdiposityPathomechanism
2022
Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications
Shah R, Chernausek S, ghormli L, Geffner M, Keady J, Kelsey M, Farrell R, Tesfaldet B, Tryggestad J, Van Name M, Isganaitis E. Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications. The Journal Of Clinical Endocrinology & Metabolism 2022, 108: 1120-1131. PMID: 36446741, PMCID: PMC10306086, DOI: 10.1210/clinem/dgac663.Peer-Reviewed Original ResearchConceptsYouth-onset type 2 diabetesType 2 diabetesMaternal diabetesHeart rate variabilityGlomerular hyperfiltrationParental diabetesGlycemic controlRate variabilityFuture cardiometabolic diseaseParental diabetes historyYouth-onset T2D.Lower heart rate variabilityRisk of complicationsWorse glycemic controlΒ-cell functionRace/ethnicityDiabetes historyCardiometabolic diseasesDiabetes outcomesPrenatal exposureUS cohortGlycemic outcomesRisk factorsDisease progressionUS CentersGrowth patterns among late preterm infants of mothers with diabetes
Buck CO, Shabanova V, Taylor SN. Growth patterns among late preterm infants of mothers with diabetes. The Journal Of Maternal-Fetal & Neonatal Medicine 2022, 35: 10116-10123. PMID: 36075588, DOI: 10.1080/14767058.2022.2119125.Peer-Reviewed Original ResearchConceptsLate preterm infantsUnexposed infantsPreterm infantsFirst postnatal weekGreater weight gainDM groupMaternal diabetesWeight gainPostnatal weekWeight trajectoriesRetrospective longitudinal analysisAge 2 yearsLong-term riskAge twoCardiometabolic diseasesExposure groupDiabetesInfantsAverage weightGrowth patternHighest average weightTerm riskEarly childhoodFurther studiesPregnancyWhole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals
Tahir U, Katz D, Avila-Pachecho J, Bick A, Pampana A, Robbins J, Yu Z, Chen Z, Benson M, Cruz D, Ngo D, Deng S, Shi X, Zheng S, Eisman A, Farrell L, Hall M, Correa A, Tracy R, Durda P, Taylor K, Liu Y, Johnson W, Guo X, Yao J, Chen Y, Manichaikul A, Ruberg F, Blaner W, Jain D, Bouchard C, Sarzynski M, Rich S, Rotter J, Wang T, Wilson J, Clish C, Natarajan P, Gerszten R. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nature Communications 2022, 13: 4923. PMID: 35995766, PMCID: PMC9395431, DOI: 10.1038/s41467-022-32275-3.Peer-Reviewed Original ResearchConceptsGenome association studiesGenomic diversityAssociation studiesWhole-genome association studiesLocus-metabolite associationsIndividuals of European ancestryIntegrative omics approachMetabolite peaksGenetic informationCardiometabolic diseasesSpecific allelesEuropean ancestryOmics approachesSickle cell diseaseMulti-ethnic cohortTransthyretin amyloidosisAncestryHereditary diseaseIdentified metabolitesCell diseaseHuman metabolismUnknown metabolitesDiversityBlack individualsJackson Heart StudyTargeting the vasculature in cardiometabolic disease
Boutagy NE, Singh AK, Sessa WC. Targeting the vasculature in cardiometabolic disease. Journal Of Clinical Investigation 2022, 132: e148556. PMID: 35289308, PMCID: PMC8920329, DOI: 10.1172/jci148556.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiometabolic diseasesCardiometabolic disease burdenOptimal medical therapyType 2 diabetesContext of atherosclerosisCardiometabolic changesCV morbidityEndothelial dysfunctionEjection fractionGlycemic controlHeart failureMedical therapyProinflammatory mediatorsVascular inflammationDisease burdenDisease progressionCardiovascular diseaseVascular remodelingPathological changesEpidemic proportionsVascular endotheliumMetabolic diseasesDiseaseVasculatureObesityMetals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Metals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States. Environmental Research 2022, 210: 112976. PMID: 35202625, PMCID: PMC9869389, DOI: 10.1016/j.envres.2022.112976.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreCohort of midlife womenIncident MetSMidlife womenHazard ratioRisk of incident MetSRisk of incident metabolic syndromeProspective cohortStudy of Women's HealthFree of MetSRisk of cardiometabolic diseasesIncident metabolic syndromeMetabolic syndromeImpaired fasting glucoseCox proportional hazards modelsHigh-density lipoprotein cholesterolHigh blood pressureMetS incidenceWomen's HealthProportional hazards modelAbdominal obesityNation Multi-Pollutant StudyDevelopment of metabolic syndromeCardiometabolic diseasesHigh triglycerides
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