2025
Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury
Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.Peer-Reviewed Original ResearchCalcium signalingCalcium channelsTherapeutic strategiesCalcium homeostasisFunction of calcium channelsDysregulated calcium signalingModulation of injuryTraumatic brain injuryBrain injuryLoss of calcium homeostasisBlast-related traumatic brain injuryDevelopment of neuroprotective interventionsIntracellular calcium dynamicsPlasma membrane stabilityExtracellular calciumBlast traumatic brain injuryPreclinical modelsTherapeutic outcomesNeuroprotective interventionsMembrane abnormalitiesPharmacological inhibitorsNeuronal somataExclusion criteriaCalcium dynamicsSecondary injury
2023
The Effects of Aging on Rod Bipolar Cell Ribbon Synapses
Shrestha A, Rameshkumar N, Boff J, Rajmanna R, Chandrasegaran T, Frederick C, Zenisek D, Vaithianathan T. The Effects of Aging on Rod Bipolar Cell Ribbon Synapses. Cells 2023, 12: 2385. PMID: 37830599, PMCID: PMC10572008, DOI: 10.3390/cells12192385.Peer-Reviewed Original ResearchConceptsRod bipolar cellsRibbon synapsesSynaptic ribbonsCalcium currentBipolar cellsRetinal ganglion cellsAge-related morphological changesBipolar cell ribbon synapsesBipolar cell terminalsGlobal health concernAge-related visual impairmentAge-related changesPlexiform layerGanglion cellsInner nuclearCochlear cellsSensory alterationsCell terminalsVisual impairmentFunctional changesHealth concernCalcium signalsSynapsesCalcium dynamicsRetina
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