2025
CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models
Leser F, Júnyor F, Pagnoncelli I, Delgado A, Medeiros I, Nóbrega A, Andrade B, de Lima M, da Silva N, Jacob L, Boyé K, Geraldo L, de Souza A, Maron-Gutierrez T, Castro-Faria-Neto H, Follmer C, Braga C, Neves G, Eichmann A, Romão L, Lima F. CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models. Journal Of Neuroinflammation 2025, 22: 31. PMID: 39894839, PMCID: PMC11789347, DOI: 10.1186/s12974-024-03318-x.Peer-Reviewed Original ResearchConceptsMouse model of PDModel of PDMouse modelDopaminergic neuronsNeuron-microglia communicationNeuron-glia communicationParkinson's diseaseCCR7-dependent mannerMicroglial cell activationCCR7 expressionCCL21-CCR7Progressive degenerative diseaseCCR7 receptorMicroglial cell migrationInflammatory profileChemokine CCL21Cell activationCCL21Therapeutic strategiesChemokine inhibitorsTherapeutic implicationsMicroglial activationReceptor pathwayCCR7Behavioral deficits
2011
EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues
Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG. EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues. The Journal Of Immunology 2011, 187: 3026-3032. PMID: 21844396, PMCID: PMC3169736, DOI: 10.4049/jimmunol.1101262.Peer-Reviewed Original ResearchConceptsActivated B cellsB cellsAb responsesNonlymphoid tissuesCCR7-dependent mannerSecondary lymphoid organsDependent Ab responsesB cell migrationLigand activityCCR7 downregulationLymphoid organsFollicular regionsEBI2Outer follicleT zoneCD40 engagementCell linesLipid ligandsLymphoidCell migrationGene 2CellsTissueSerial movementsEarly wave
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