2025
Proceedings of the Clinical Microbiology Open 2024: artificial intelligence applications in clinical microbiology
Bard J, Prinzi A, Larkin P, Peaper D, Rhoads D. Proceedings of the Clinical Microbiology Open 2024: artificial intelligence applications in clinical microbiology. Journal Of Clinical Microbiology 2025, 63: e01804-24. PMID: 40145748, PMCID: PMC11980357, DOI: 10.1128/jcm.01804-24.Peer-Reviewed Original ResearchConceptsAmerican Society for MicrobiologyClinical microbiology practiceClinical microbiology laboratoriesClinical microbiologyMicrobiology laboratoryMicrobiological practiceClinical microbiologistsClinical laboratoriesMicrobiologyArtificial intelligenceClinicLaboratory directorsMicrobiologistsArtificial intelligence applicationsBiotechnologyChallenges of AIEngineering a genomically recoded organism with one stop codon
Grome M, Nguyen M, Moonan D, Mohler K, Gurara K, Wang S, Hemez C, Stenton B, Cao Y, Radford F, Kornaj M, Patel J, Prome M, Rogulina S, Sozanski D, Tordoff J, Rinehart J, Isaacs F. Engineering a genomically recoded organism with one stop codon. Nature 2025, 639: 512-521. PMID: 39910296, PMCID: PMC11903333, DOI: 10.1038/s41586-024-08501-x.Peer-Reviewed Original Research
2022
Tuning protein half-life in mouse using sequence-defined biopolymers functionalized with lipids
Vanderschuren K, Arranz-Gibert P, Khang M, Hadar D, Gaudin A, Yang F, Folta-Stogniew E, Saltzman WM, Amiram M, Isaacs FJ. Tuning protein half-life in mouse using sequence-defined biopolymers functionalized with lipids. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2103099119. PMID: 35046019, PMCID: PMC8794819, DOI: 10.1073/pnas.2103099119.Peer-Reviewed Original ResearchConceptsSequence-defined biopolymersProtein-based drugsModel fusion proteinProof of conceptSynthetic biopolymersBroad applicationsMaterials scienceProgrammable approachLow toxicityHigh specificityPeptide therapeuticsBiopolymersLimited side effectsConjugation sitesBlood serumBiotechnologyTechnical foundationFusion proteinMouse serumBiophysical propertiesAzidophenylalanineApplicationsPast decadeTherapeutics
2020
DNA Origami Post‐Processing by CRISPR‐Cas12a
Xiong Q, Xie C, Zhang Z, Liu L, Powell JT, Shen Q, Lin C. DNA Origami Post‐Processing by CRISPR‐Cas12a. Angewandte Chemie International Edition 2020, 59: 3956-3960. PMID: 31883145, PMCID: PMC7101258, DOI: 10.1002/anie.201915555.Peer-Reviewed Original ResearchConceptsDNA origami structuresCRISPR-Cas12aDNA origami devicesDNA origami designDNA origami techniqueNanomaterial fabricationFunctional nanodevicesDNA origamiScaffold strandTremendous promiseCutting-edge toolsVersatile toolNanodevicesNanostructuresFacileFabricationBiocompatibilityBiotechnologySequence specificityOrigamiEnzymatic methodMechanical propertiesStructural transformationDevicesIntricate structureDNA Origami Post‐Processing by CRISPR‐Cas12a
Xiong Q, Xie C, Zhang Z, Liu L, Powell J, Shen Q, Lin C. DNA Origami Post‐Processing by CRISPR‐Cas12a. Angewandte Chemie 2020, 132: 3984-3988. DOI: 10.1002/ange.201915555.Peer-Reviewed Original ResearchDNA origami structuresCRISPR-Cas12aDNA origami devicesDNA origami designDNA origami techniqueNanomaterial fabricationFunctional nanodevicesDNA origamiScaffold strandTremendous promiseCutting-edge toolsVersatile toolNanodevicesNanostructuresFacileFabricationBiocompatibilityBiotechnologySequence specificityOrigamiEnzymatic methodMechanical propertiesStructural transformationDevicesIntricate structure
2019
Bioinformatics applied to biotechnology: A review towards bioenergy research
de Carvalho L, Borelli G, Camargo A, de Assis M, de Ferraz S, Fiamenghi M, José J, Mofatto L, Nagamatsu S, Persinoti G, Silva N, Vasconcelos A, Pereira G, Carazzolle M. Bioinformatics applied to biotechnology: A review towards bioenergy research. Biomass And Bioenergy 2019, 123: 195-224. DOI: 10.1016/j.biombioe.2019.02.016.Peer-Reviewed Original ResearchSecond-generation ethanol technologyGenetic engineering toolsLignocellulosic biomassMicroorganism fermentationBioethanol productionEthanol technologyBiotechnological researchInteresting phenotypesPromising technologyMass spectrometry technologyNon-renewable originBiological systemsGenetic modificationNew organismsNew industrial processesMetabolic processesMolecular biologyDNA sequencingBioinformatics workflowsBioenergy researchHigh-performance computingIndustrial applicationsSpectrometry technologyCarbon sourceBiotechnology
2016
Chapter 26 Synthetic Biology An Emerging Field for Developing Economies
Koelmel J, Sebastian A, Prasad M. Chapter 26 Synthetic Biology An Emerging Field for Developing Economies. 2016, 665-685. DOI: 10.1016/b978-0-12-802830-8.00026-5.Peer-Reviewed Original ResearchSynthetic biologySystems biology approachBiology approachBiotic factorsAreas of biotechnologyEcological structureEnzyme researchField of bionanotechnologyBiologyAnthropogenic activitiesBioremediationBiotechnology industryBiological systemsLarge-scale applicationsAlarming depletionPhytoremediationPlantsGrowthMicroorganismsConservationBiotechnologyFaster rateBionanotechnologyBioresourcesRe-establish balance
2013
Microalgae‐Derived Chemicals: Opportunity for an Integrated Chemical Plant
Kermanshahi‐Pour A, Zimmerman J, Anastas P. Microalgae‐Derived Chemicals: Opportunity for an Integrated Chemical Plant. 2013, 387-433. DOI: 10.1002/9781118659892.ch15.Peer-Reviewed Original ResearchValuable chemicalsAlgal biotechnologyDownstream technologiesBiotechnological processesEfficient separationFine chemicalsMicroalgal speciesPlant approachCulture strategyExamples of chemicalsSimultaneous productionProcess integrationProtein fractionsCommercial scaleMicroalgaeCultivation systemsChemicalsBiotechnologyBioprocessesMultiple chemicalsSpeciesPlantsTechnologyProductionProduction systemsExterior design: strategies for redecorating the bacterial surface with small molecules
Gautam S, Gniadek TJ, Kim T, Spiegel DA. Exterior design: strategies for redecorating the bacterial surface with small molecules. Trends In Biotechnology 2013, 31: 258-267. PMID: 23490213, PMCID: PMC3641905, DOI: 10.1016/j.tibtech.2013.01.012.BooksConceptsExciting new setField of biotechnologySurface displayBacterial surface displayBacterial platformSmall moleculesUnique propertiesSurface of bacteriaHeterologous proteinsSynthetic materialsGreat potentialRecombinant techniquesBacterial surfaceSuch technologiesSurfaceBiocatalysisNovel methodBiomedicineBiotechnologyBasic bacteriologyCompoundsMoleculesPlatformTechnologyProperties
2001
In Vitro Selection of Kinase and Ligase Deoxyribozymes
Li Y, Breaker R. In Vitro Selection of Kinase and Ligase Deoxyribozymes. Methods 2001, 23: 179-190. PMID: 11181037, DOI: 10.1006/meth.2000.1119.Peer-Reviewed Original ResearchConceptsDNA ligationModern living systemsDNA kinaseEnzymatic functionRandom sequence populationVitro SelectionProtein enzymesConstruction of DNADNA constructsDNA phosphorylationDNADeoxyribozymesKinaseLiving systemsFundamental roleChemical reactionsAdenylationFundamental questionsBiocatalysisPhosphorylationEnzymeBiotechnologySelection strategyDiscoveryDetailed overview
1999
Direct observation of oxidative stress on the cell wall of Saccharomyces cerevisiae strains with atomic force microscopy
de Souza Pereira R, Geibel J. Direct observation of oxidative stress on the cell wall of Saccharomyces cerevisiae strains with atomic force microscopy. Molecular And Cellular Biochemistry 1999, 201: 17-24. PMID: 10630618, DOI: 10.1023/a:1007007704657.Peer-Reviewed Original ResearchConceptsCell wallGroup of yeastsOxidative damageOxidative stressIndustrial strainsMolecular biologySurface proteinsInduced oxidative damageGerman strainsAmerican strainsMM diamideAtomic force microscopyStrainsSaccharomycesYeastBiologyProteinForce microscopyRapid screening processBiotechnologyPore sizeStressSurface poresOxidantsDiamide
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