2025
Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report
Yang Y, Matuskey D, Benjamin C, Fesharaki-Zadeh A. Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report. Cognitive And Behavioral Neurology 2025, 38: 66-72. PMID: 40298273, DOI: 10.1097/wnn.0000000000000392.Peer-Reviewed Original ResearchConceptsBehavioral variant frontotemporal dementiaDiagnosis of behavioural variant frontotemporal dementiaFrontotemporal dementiaEpisodic memory lossLoss of empathyCompulsive behaviorsExecutive functionProgressive behavioral deficitsPsychiatric diagnosisPsychiatric disordersBehavioral deficitsRight hippocampusRight hemisphereBehavioral agitationPersonality changesNeuroimaging findingsInstrumental activities of daily livingMemory lossRight lateral ventricleSevere hypometabolismLateral ventricleParenchymal volume lossClinician's abilityInstrumental activitiesVolume lossOxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs
Lyu W, Li Y, Yao A, Tan Q, Zhang R, Zhao J, Guo K, Jiang Y, Tian R, Zhang Y. Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs. Translational Psychiatry 2025, 15: 76. PMID: 40050270, PMCID: PMC11885833, DOI: 10.1038/s41398-025-03296-5.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMutant damsWild-typeMaternal behaviorASD risk genesLicking behaviorAbundant scaffolding proteinImpaired social interactionEffects of oxytocinCRISPR/Cas9 methodologyRisk genesMutant dogsNursing frequencyOXT treatmentBehavioral deficitsRepetitive behaviorsPotential therapeutic strategySpectrum disorderCCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models
Leser F, Júnyor F, Pagnoncelli I, Delgado A, Medeiros I, Nóbrega A, Andrade B, de Lima M, da Silva N, Jacob L, Boyé K, Geraldo L, de Souza A, Maron-Gutierrez T, Castro-Faria-Neto H, Follmer C, Braga C, Neves G, Eichmann A, Romão L, Lima F. CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models. Journal Of Neuroinflammation 2025, 22: 31. PMID: 39894839, PMCID: PMC11789347, DOI: 10.1186/s12974-024-03318-x.Peer-Reviewed Original ResearchConceptsMouse model of PDModel of PDMouse modelDopaminergic neuronsNeuron-microglia communicationNeuron-glia communicationParkinson's diseaseCCR7-dependent mannerMicroglial cell activationCCR7 expressionCCL21-CCR7Progressive degenerative diseaseCCR7 receptorMicroglial cell migrationInflammatory profileChemokine CCL21Cell activationCCL21Therapeutic strategiesChemokine inhibitorsTherapeutic implicationsMicroglial activationReceptor pathwayCCR7Behavioral deficits
2024
Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol
Tong X, Hussain H, Shamaladevi N, Norenberg M, Fadel A, Hiba O, Abdeljalil E, El-Mansoury B, Kempuraj D, Natarajan S, Schally A, Jaszberenyi M, Salgueiro L, Paidas M, Jayakumar A. Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol. Biology 2024, 13: 228. PMID: 38666840, PMCID: PMC11048384, DOI: 10.3390/biology13040228.Peer-Reviewed Original ResearchFemale ratsMiddle-aged ratsAged male ratsAged female ratsBehavioral deficitsType C HEHepatic encephalopathyBrain edemaTAA-induced HELiver failureAged malesAged femalesMale ratsBehavioral changesAdult ratsChronic HEDevelopment of hepatic encephalopathySustained plasma levelsAcute liver failureMiddle-agedEtOHAcute HEC HEBrainDrug-induced
2023
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Stoner A, Fu L, Nicholson L, Zheng C, Toyonaga T, Spurrier J, Laird W, Cai Z, Strittmatter S. Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein. Alzheimer's Research & Therapy 2023, 15: 201. PMID: 37968719, PMCID: PMC10647125, DOI: 10.1186/s13195-023-01345-z.Peer-Reviewed Original ResearchConceptsSynapse lossDKI miceTau accumulationBrain immune activationNeural network dysfunctionPhospho-tau accumulationAccumulation of tauNeuronal genesInflammatory markersAD miceAβ levelsPrion proteinDystrophic neuritesImmune activationTau pathologyNeuronal gene expressionAmyloid-β OligomersGliotic reactionNetwork dysfunctionBehavioral deficitsSynaptic failureAD modelMemory impairmentAlzheimer's diseaseFunction of ageModeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing
Tian R, Li Y, Zhao H, Lyu W, Zhao J, Wang X, Lu H, Xu H, Ren W, Tan Q, Shi Q, Wang G, Zhang Y, Lai L, Mi J, Jiang Y, Zhang Y. Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing. Molecular Psychiatry 2023, 28: 3739-3750. PMID: 37848710, DOI: 10.1038/s41380-023-02276-9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderNon-human primatesDog-human social interactionsPreclinical studiesBattery of behavioral assaysSocial behavior deficitsASD mouse modelsSocial interactionReduced social interactionCRISPR/Cas9 gene editingGenetic mutant miceNeural circuit mechanismsSocial withdrawalBehavioral findingsPsychiatric disordersBehavioral deficitsHeightened anxietyCanine modelSHANK3 mutationsSHANK3 geneCircuit mechanismsMutant miceMouse modelBehavioral assaysLongitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease
Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, DeLuca K, Hamodi A, Owens A, Ha Y, Qu A, Onofrey J, Papademetris X, Chakravarty M, Crair M, Strittmatter S, Lake E. Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3914.Peer-Reviewed Original ResearchMouse model of Alzheimer's diseaseModel of Alzheimer's diseaseMesoscale calcium imagingAlzheimer's diseaseBehavioral deficitsExcitatory neural activityMultimodal neuroimagingBOLD signalSimultaneous fMRINeuroimaging changesNeural activityBOLD fMRIPreliminary evidenceCalcium imagingClinically accessible biomarkersMesoscopic calcium imagingSpontaneous activityFMRINeuroimagingBOLDDeficitsComplex relationshipNeonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice
Stevens H, Scuderi S, Collica S, Tomasi S, Horvath T, Vaccarino F. Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice. Translational Psychiatry 2023, 13: 89. PMID: 36906620, PMCID: PMC10008554, DOI: 10.1038/s41398-023-02372-y.Peer-Reviewed Original ResearchConceptsFibroblast growth factor receptor 2Anxiety-like behaviorAttention deficit hyperactivity disorderAstroglial cellsGrowth factor receptor 2Reduced anxiety-like behaviorGlia-neuron interactionsAstroglial cell functionEarly postnatal periodFactor receptor 2Early postnatal lossPostnatal mouse brainWeeks of ageDeficit hyperactivity disorderGlial cellsGlutamine synthetase expressionBehavioral deficitsPostnatal periodReceptor 2Floxed miceHGFAP-CreMouse brainNeonatal lossPostnatal astrogliaPostnatal lossA Measure of Neural Function Provides Unique Insights into Behavioral Deficits in Acute Stroke
Vanderschelden B, Erani F, Wu J, de Havenon A, Srinivasan R, Cramer S. A Measure of Neural Function Provides Unique Insights into Behavioral Deficits in Acute Stroke. Stroke 2023, 54: e25-e29. PMID: 36689596, PMCID: PMC9881885, DOI: 10.1161/strokeaha.122.040841.Peer-Reviewed Original ResearchConceptsInitial NIHSS scoreNIHSS scoreAcute strokeNeural functionBehavioral deficitsHealth Stroke Scale scoreBivariate analysisInitial National InstitutesStroke Scale scoreEmergency department settingMultivariable linear regressionInfarct volumeEEG measuresStroke deficitsDiabetes statusEmergency departmentEEG findingsSelection operator (LASSO) regressionUniversity HospitalDepartment settingSpectral powerScale scoreClinical modelStrokeMultivariate modelα-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2022
Prefrontal circuits guiding social preference: Implications in autism spectrum disorder
Fortier AV, Meisner OC, Nair AR, Chang SWC. Prefrontal circuits guiding social preference: Implications in autism spectrum disorder. Neuroscience & Biobehavioral Reviews 2022, 141: 104803. PMID: 35908593, PMCID: PMC10122914, DOI: 10.1016/j.neubiorev.2022.104803.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderUnderlying neural mechanismsSpectrum disorderTreatment developmentSocial preferencesSocial preference behaviorSocial cognitionUnderlying neural circuitsAtypical developmentNeural mechanismsPrefrontal circuitsCircuit-level dysfunctionBehavioral disruptionNeural circuitsBehavioral deficitsAnimal model researchAnimal modelsCommon circuitsDiagnostic prevalenceConvergent circuitClinical presentationNeurological alterationsTreatment optionsEffects of dysregulationCognitionDoes Anesthesia and Surgery During Pregnancy Really Affect Learning and Behavior in the Offspring: The Holy Grail in Anesthesiology Research
Fardelmann K, Gaiser R. Does Anesthesia and Surgery During Pregnancy Really Affect Learning and Behavior in the Offspring: The Holy Grail in Anesthesiology Research. Obstetric Anesthesia Digest 2022, 42: 9-9. DOI: 10.1097/01.aoa.0000816744.14772.6a.Commentaries, Editorials and LettersInhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism
Tzanoulinou S, Musardo S, Contestabile A, Bariselli S, Casarotto G, Magrinelli E, Jiang YH, Jabaudon D, Bellone C. Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism. Molecular Psychiatry 2022, 27: 2080-2094. PMID: 35022531, PMCID: PMC9126815, DOI: 10.1038/s41380-021-01427-0.Peer-Reviewed Original ResearchConceptsAcute inflammatory responseInflammatory responseSHANK3 geneTransient receptor potential vanilloid 4Shank3 mouse modelAutism spectrum disorderGenetic risk factorsInhibition of TRPV4Ex vivo approachNeuron hyperexcitabilityRisk factorsBehavioral deficitsNucleus accumbensMouse modelTRPV4 inhibitionBehavioral alterationsSocial deficitsSHANK3 mutationsCircuit mechanismsNeurodevelopmental diseasesGenetic alterationsTypes of mutationsHeterozygous deletionIdiopathic autismEnvironmental insultsDeficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice
Bai W, Luo X, Jin B, Zhu K, Guo W, Zhu X, Qin X, Yang Z, Zhao J, Chen S, Wang R, Hao J, Wang F, Shi Y, Kong D, Zhang W. Deficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice. 动物学研究 2022, 43: 851-870. PMID: 36031768, PMCID: PMC9486526, DOI: 10.24272/j.issn.2095-8137.2022.122.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderTARP γKO miceAttention deficit hyperactivity disorder-like behaviorsPrefrontal cortexDysregulation of dopaminergicDevelopment of ADHDGlutamate receptor complexAMPA receptor subunitsTransmembrane AMPA receptor regulatory protein (TARP) γADHD-like behaviorsADHD-like phenotypeMajor behavioral deficitsGlutamatergic transmissionHippocampal synaptosomesRisk factorsSchool-aged childrenAlternative animal modelBehavioral deficitsNew therapiesKnockout miceAnimal modelsProtein γMemory deficitsReceptor subunits
2021
Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model
Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. Journal Of Neuroscience 2021, 42: 1035-1053. PMID: 34887320, PMCID: PMC8824494, DOI: 10.1523/jneurosci.1371-20.2021.Peer-Reviewed Original ResearchConceptsCortical circuitsCognitive deficitsCortical circuit modelAltered excitation-inhibition balanceExcitatory pyramidal neuronsNMDA receptor hypofunctionCerebral cortical circuitsExcitation-inhibition balancePyramidal neuronsReceptor hypofunctionDistinct time coursesSynaptic excitationInhibitory interneuronsMultiple neuropsychiatric disordersBehavioral deficitsSynaptic balanceSynaptic levelLatest evidenceNeuropsychiatric disordersCognitive functionCircuit mechanismsBehavioral effectsPsychometric performanceBehavioral levelTask paradigmHeat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density
Zarate N, Intihar T, Yu D, Sawyer J, Tsai W, Syed M, Carlson L, Gomez-Pastor R. Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density. International Journal Of Molecular Sciences 2021, 22: 13113. PMID: 34884918, PMCID: PMC8657899, DOI: 10.3390/ijms222313113.Peer-Reviewed Original ResearchConceptsHeat shock transcription factor 1PSD-95 levelsPSD-95 expressionPSD-95Huntington's diseaseShock transcription factor 1Synaptic protein levelsFactor 1Heat shock factor 1Direct regulatory relationshipIonotropic glutamate receptorsAge-dependent mannerShock factor 1Protein homeostasisWT miceAcute reductionSynaptic dysfunctionGene regulationTranscription factor 1Synaptic densityProtein essentialSynaptic punctaGlutamate receptorsBehavioral deficitsExcitatory synapsesDisordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression
Cleary C, James S, Maher B, Mulkey D. Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression. Nature Communications 2021, 12: 5962. PMID: 34645823, PMCID: PMC8514575, DOI: 10.1038/s41467-021-26263-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsBenzimidazolesBrain StemCarbon DioxideDisease Models, AnimalFaciesGene Expression RegulationHaploinsufficiencyHomeodomain ProteinsHumansHyperventilationIntellectual DisabilityMaleMiceMice, KnockoutNAV1.8 Voltage-Gated Sodium ChannelNeuronsPsychomotor PerformancePyrazolesRespirationTranscription Factor 4Transcription FactorsConceptsPitt-Hopkins syndromeParafacial neuronsBreathing problemsEpisodes of hyperventilationFunction of neuronsNav1.8 expressionPTH patientsRetrotrapezoid nucleusNav1.8 channelsTranscription factor 4Behavioral deficitsMouse modelRespiratory functionBehavioral abnormalitiesTherapeutic potentialSyndrome modelDevelopmental delaySelective lossNeuronsIntellectual disabilityFactor 4Functional haploinsufficiencyBehavioral levelNav1.8ApneaPsilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, Kwan AC. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron 2021, 109: 2535-2544.e4. PMID: 34228959, PMCID: PMC8376772, DOI: 10.1016/j.neuron.2021.06.008.Peer-Reviewed Original ResearchConceptsFrontal cortexDendritic spinesMouse medial frontal cortexLayer 5 pyramidal neuronsSpine formation ratesApical dendritic spinesMedial frontal cortexUntapped therapeutic potentialPyramidal neuronsSingle doseExcitatory neurotransmissionBehavioral deficitsBeneficial actionsStructural remodelingSynaptic rewiringMammalian brainTherapeutic potentialNeural adaptationUse of psychedelicsSerotonergic psychedelicsSpine sizeTwo-photon microscopyCortexPsilocybinSpineMacro- and Microscale Stress–Associated Alterations in Brain Structure: Translational Link With Depression
Banasr M, Sanacora G, Esterlis I. Macro- and Microscale Stress–Associated Alterations in Brain Structure: Translational Link With Depression. Biological Psychiatry 2021, 90: 118-127. PMID: 34001371, DOI: 10.1016/j.biopsych.2021.04.004.Peer-Reviewed Original ResearchConceptsMajor depressive disorderStress-related disordersCytoarchitectural alterationsPathophysiology of MDDChronic stress pathologyDepressive-like behaviorChronic stress modelAnimal stress modelsPositron emission tomographyHuman brain tissueAstroglial alterationsSynaptic deficitsNeurochemical changesDepressive disorderBehavioral deficitsRodent modelsBrain tissueEmission tomographyDepression symptomatologyLiving brainBrain structuresNovel drugsTranslational linkStress pathologyDisordersEffect of Methylene Blue on White Matter Injury after Ischemic Stroke
Cheng Q, Chen X, Ma J, Jiang X, Chen J, Zhang M, Wu Y, Zhang W, Chen C. Effect of Methylene Blue on White Matter Injury after Ischemic Stroke. Oxidative Medicine And Cellular Longevity 2021, 2021: 6632411. PMID: 33603949, PMCID: PMC7872771, DOI: 10.1155/2021/6632411.Peer-Reviewed Original ResearchConceptsWhite matter injuryMiddle cerebral artery occlusionCerebral artery occlusionInfarct volumeIschemic strokeArtery occlusionBehavioral deficitsFDA-grandfathered drugWhite matter protectionBrain white matter injuryAdministration of MBGarcia neurological scoresTherapeutic time windowEffect of methylene bluePhotothrombotic middle cerebral artery occlusionPotential therapeutic effectsFoot-fault testNeurological deficitsMyelin basic proteinIntraperitoneal administrationNeurological scoreAnimal modelsTherapeutic effectMB administrationTTC staining
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