2025
DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress
Alim S, Cheppali S, Pawar S, Swamy M. DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress. Biochimica Et Biophysica Acta (BBA) - Proteins And Proteomics 2025, 1873: 141064. PMID: 39956303, DOI: 10.1016/j.bbapap.2025.141064.Peer-Reviewed Original ResearchConceptsChaperone-like activitySeminal plasmaFibronectin type IITetramer to monomersSperm capacitationSurface hydrophobicityMolecular chaperonesClient proteinsHeat shock proteinsBiophysical studiesAlcohol dehydrogenaseOxidative stressPhysiological ligandsShock proteinsProteinHead group moietySHspsBinding of phosphorylcholineCholine phospholipidsBindingFibronectinDehydrogenaseChaperoneSpermMammals
2020
Genome-Wide Natural Selection Signatures Are Linked to Genetic Risk of Modern Phenotypes in the Japanese Population
Yasumizu Y, Sakaue S, Konuma T, Suzuki K, Matsuda K, Murakami Y, Kubo M, Palamara P, Kamatani Y, Okada Y. Genome-Wide Natural Selection Signatures Are Linked to Genetic Risk of Modern Phenotypes in the Japanese Population. Molecular Biology And Evolution 2020, 37: 1306-1316. PMID: 31957793, PMCID: PMC7182208, DOI: 10.1093/molbev/msaa005.Peer-Reviewed Original ResearchConceptsSelection signaturesNatural selection signaturesTrait-associated variantsGenome-wide scanGenome-wide significanceAlcohol dehydrogenaseNatural selection studyPopulation-specific featuresAlcohol-related phenotypesAdaptive evolutionFine-mappingGenetic lociCluster locusUK Biobank ResourcePhenotypic dataHuman phenotypesSelection pressureJapanese populationEnrichment analysisPopulation-specific evidencePhenotypic spectrumPhenotypeBiobank ResourceGenetic riskImmune-related diseases
2014
Transgenic Mouse Models for Alcohol Metabolism, Toxicity, and Cancer
Heit C, Dong H, Chen Y, Shah YM, Thompson DC, Vasiliou V. Transgenic Mouse Models for Alcohol Metabolism, Toxicity, and Cancer. Advances In Experimental Medicine And Biology 2014, 815: 375-387. PMID: 25427919, PMCID: PMC4323349, DOI: 10.1007/978-3-319-09614-8_22.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsReactive oxygen speciesAldehyde dehydrogenasesCritical biological functionsAlcohol dehydrogenaseFormation of proteinHuman genesBiological functionsMolecular mechanismsVariety of cancersPrimary enzymeGenetic defectsOxygen speciesEnzymeNitrogen speciesEthanol metabolismTransgenic mouse modelOxidative stressSpeciesCytochrome P450Pathogenic eventsMetabolismGenetic polymorphismsAntioxidant mechanismsAlcohol-induced toxicityAlcohol-metabolizing enzymes
2011
Mesophilic alcohol dehydrogenase behavior in imidazolium based ionic liquids
Dabirmanesh B, Khajeh K, Akbari J, Falahati H, Daneshjoo S, Heydari A. Mesophilic alcohol dehydrogenase behavior in imidazolium based ionic liquids. Journal Of Molecular Liquids 2011, 161: 139-143. DOI: 10.1016/j.molliq.2011.05.007.Peer-Reviewed Original ResearchIonic liquidsWater-miscible ionic liquidMiscible ionic liquidsAqueous IL mixturesIonic liquid concentrationAssociated conformational changesIL cationsIL mixturesOrganic solventsCatalyzed reactionsBiocatalytic processesLiquid concentrationLiquidConformational changesFluorescence techniqueStabilityImidazoliumWide applicationAnionsAlcohol dehydrogenaseSolventCationsILsReactionConcentration
2009
Effects of ionic liquids on the kinetic behavior of thermophilic alcohol dehydrogenase and its mesophilic counterpart
Dabirmanesh B, Falahati H, Khajeh K, Akbari J, Heydari A. Effects of ionic liquids on the kinetic behavior of thermophilic alcohol dehydrogenase and its mesophilic counterpart. New Biotechnology 2009, 25: s143. DOI: 10.1016/j.nbt.2009.06.470.Peer-Reviewed Original Research
2006
Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence
Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence. American Journal Of Human Genetics 2006, 78: 973-987. PMID: 16685648, PMCID: PMC1474098, DOI: 10.1086/504113.Peer-Reviewed Original ResearchConceptsADH gene clusterGene clusterAldehyde dehydrogenase geneStructured association analysisConventional association methodsALDH2 geneAlcohol dehydrogenaseAdh geneDehydrogenase geneAssociation analysisSusceptibility lociGenesRisk genesFunctional variantsDisease allelesFunctional complexityCase-control sampleAncestry informative markersHardy-Weinberg equilibrium testDisequilibrium measuresMultiple significant associationsAllelesAlcohol-metabolizing enzymesConventional case-control comparisonsUnlinked ancestry-informative markers
1993
Sex determination gene TASSELSEED2 of maize encodes a short-chain alcohol dehydrogenase required for stage-specific floral organ abortion Cell 74, 757–768
Delong A, Calderon-Urrea A, Dellaporta S. Sex determination gene TASSELSEED2 of maize encodes a short-chain alcohol dehydrogenase required for stage-specific floral organ abortion Cell 74, 757–768. Trends In Genetics 1993, 9: 378. DOI: 10.1016/0168-9525(93)90129-6.Peer-Reviewed Original ResearchSex determination gene TASSELSEED2 of maize encodes a short-chain alcohol dehydrogenase required for stage-specific floral organ abortion
DeLong A, Calderon-Urrea A, Dellaporta S. Sex determination gene TASSELSEED2 of maize encodes a short-chain alcohol dehydrogenase required for stage-specific floral organ abortion. Cell 1993, 74: 757-768. PMID: 8358795, DOI: 10.1016/0092-8674(93)90522-r.Peer-Reviewed Original ResearchConceptsDevelopmental programShort-chain alcohol dehydrogenasesFemale developmental programMale developmental programsShort-chain alcohol dehydrogenaseAmino acid sequenceMutant plantsSexual fateFloral meristemOrgan primordiaUnisexual flowersOrgan abortionFloral structuresSomatic tissuesAcid sequenceMale inflorescencesAc excisionSignificant similarityStamen primordiaAlcohol dehydrogenasesPhenotypic instabilitySexual maturityPrimordiaAlcohol dehydrogenaseGynoecium
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