2025
Association between hyperkalemia and outcomes in hospitalized patients with acute kidney injury
Wang W, Yang H, Wilson F, Gallagher M, Feng Y. Association between hyperkalemia and outcomes in hospitalized patients with acute kidney injury. Intensive And Critical Care Nursing 2025, 90: 104118. PMID: 40554252, DOI: 10.1016/j.iccn.2025.104118.Peer-Reviewed Original ResearchAcute kidney injuryNadir of riskPrimary outcomeSerum potassiumKidney injuryAKI progressionAssociated with AKI progressionOdds ratioHospitalized patientsAcute kidney injury durationAcute kidney injury patientsAssociation of hyperkalemiaMeasured serum potassiumOutcomes of hospitalized patientsSerum potassium levelsRestricted cubic spline regressionDays of randomizationAcute kidney injury progressionConfidence intervalsCubic spline regressionDose-response relationshipDischarged to homeOutcomes of interestsComposite outcomeHyperkalemiaPrediction Model for Safe Contrast Volume Thresholds to Prevent Postcontrast Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair
Bader J, Li Y, Lee C, Li J, Said S, Slade M, Huang Y, Kuwayama D, Guzman R, Ochoa Chaar C. Prediction Model for Safe Contrast Volume Thresholds to Prevent Postcontrast Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair. Journal Of Vascular Surgery 2025 PMID: 40490161, DOI: 10.1016/j.jvs.2025.05.041.Peer-Reviewed Original ResearchElective endovascular abdominal aortic aneurysm repairEndovascular abdominal aortic aneurysm repairRisk of PC-AKIAbdominal aortic aneurysm repairMultivariate logistic regression analysisAortic aneurysm repairPC-AKIAcute kidney injuryLogistic regression analysisPerioperative mortalityAneurysm repairKidney injuryComplication of endovascular abdominal aortic aneurysm repairPatient characteristicsIncidence of preoperative comorbiditiesPost-contrast acute kidney injuryPostcontrast acute kidney injuryAssociated with development of chronic kidney diseaseAssociated with perioperative mortalityDevelopment of chronic kidney diseaseVascular Quality Initiative databasePreoperative patient characteristicsKaplan-Meier analysisProlonged hospital stayRenal artery stentingPredicting the Use of Dialysis for Acute Kidney Injury in Patients with Cirrhosis—Does Diagnosis Matter?
Belcher J. Predicting the Use of Dialysis for Acute Kidney Injury in Patients with Cirrhosis—Does Diagnosis Matter? Digestive Diseases And Sciences 2025, 1-3. PMID: 40471496, DOI: 10.1007/s10620-025-09143-3.Peer-Reviewed Original ResearchResolution of acute kidney injury following intensive dialysis for oxalate nephropathy.
Roth J, Buglioni A, Dahl N. Resolution of acute kidney injury following intensive dialysis for oxalate nephropathy. Clinical Nephrology 2025 PMID: 40454527, DOI: 10.5414/cn111664.Peer-Reviewed Original ResearchAcute kidney injuryOxalate nephropathyKidney injuryStage III acute kidney injuryIII acute kidney injuryResolution of acute kidney injuryUrinary excretion of oxalateIncreased urinary excretion of oxalateAbsorption of dietary oxalateDeposition of calcium oxalate crystalsIncreased absorption of dietary oxalateSerum oxalate levelsExcretion of oxalateIncreased urinary excretionChronic kidney diseaseRenal outcomesRenal recoveryEnteric hyperoxaluriaBariatric proceduresFat malabsorptionIntensive dialysisSecondary hyperoxaluriaRenal parenchymaBiliopancreatic diversionBariatric patientsUpdate on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches
Sahutoglu T, Perazella M. Update on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches. Kidney International Reports 2025, 10: 1643-1656. DOI: 10.1016/j.ekir.2025.03.050.Peer-Reviewed Original ResearchAcute tubulointerstitial nephritisAcute kidney injuryC-reactive proteinAcute kidney diseaseTubulointerstitial nephritisType IV hypersensitivity mechanismKidney diseaseAcute kidney injury etiologyTh2-mediated immune responsesSerum C-reactive proteinTriggered by medicationsTumor necrosis factor (TNF)-aInterleukin (IL)-9Urinary retinol-binding proteinT helper (Th)1T cell polarizationIrreversible kidney damageInflammatory endotypesImprove patient outcomesPrompt diagnosisKidney biopsyT cellsClinical featuresDiagnostic challengeImmune heterogeneityThe Discrepancy Between Estimated GFR Cystatin C and Estimated GFR Creatinine at 3 Months After Hospitalization and Long-Term Adverse Outcomes
Wen Y, Srialluri N, Farrington D, Thiessen-Philbrook H, Menez S, Moledina D, Coca S, Ikizler T, Siew E, Go A, Hsu C, Himmelfarb J, Chinchilli V, Kaufman J, Kimmel P, Garg A, Grams M, Parikh C. The Discrepancy Between Estimated GFR Cystatin C and Estimated GFR Creatinine at 3 Months After Hospitalization and Long-Term Adverse Outcomes. Kidney International Reports 2025, 10: 1896-1906. DOI: 10.1016/j.ekir.2025.04.003.Peer-Reviewed Original ResearchAcute kidney injuryEnd-stage kidney diseaseHeart failure hospitalizationFailure hospitalizationCystatin CHospitalized adultsRisk of heart failure hospitalizationHigher risk of heart failure hospitalizationLong-term adverse outcomesMedian follow-upRisk of end-stage kidney diseaseAge of study participantsPrognostic valuePrognostic markerCardiac eventsKidney injuryRisk stratificationFollow-upAdverse outcomesKidney diseaseEGFRcrHospitalized patientsHigh riskSurvival analysisEGFRcysPrediction Model for Safe Contrast Volume Thresholds—Preventing Postcontrast Acute Kidney Injury to Decrease Mortality After Endovascular Abdominal Aortic Aneurysm Repair
Bader J, Li J, Li Y, Lee C, Said S, Slade M, Huang Y, Guzman R, Chaar C. Prediction Model for Safe Contrast Volume Thresholds—Preventing Postcontrast Acute Kidney Injury to Decrease Mortality After Endovascular Abdominal Aortic Aneurysm Repair. Journal Of Vascular Surgery 2025, 81: e310-e312. DOI: 10.1016/j.jvs.2025.03.457.Peer-Reviewed Original ResearchTAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis
Krishna M, Joseph M, Ezenna C, Pereira V, Rossi R, Akman Z, Rubens M, Mahadevan V, Nanna M, Goldsweig A. TAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis. Cardiovascular Revascularization Medicine 2025 PMID: 40425422, DOI: 10.1016/j.carrev.2025.05.021.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementPatient-prosthesis mismatchIntermediate surgical riskSevere patient-prosthesis mismatchAcute kidney injuryAortic valve replacementPermanent pacemaker implantationRandomized controlled trialsSurgical riskParavalvular leakFollow-upValve replacementPacemaker implantationAtrial fibrillationClinical outcomes of transcatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementRate of permanent pacemaker implantationSafety of transcatheter aortic valve replacementBenefits of transcatheter aortic valve replacementNew-onset atrial fibrillationRates of all-cause deathAortic valve reinterventionNew-onset AFSevere aortic stenosisPostoperative complications in patients with sickle cell disease undergoing single-level anterior cervical discectomy and fusion
Maloy G, Doshi R, Day W, Dhodapkar M, Halperin S, Jayaram R, Jain B, Grauer J, Varthi A. Postoperative complications in patients with sickle cell disease undergoing single-level anterior cervical discectomy and fusion. North American Spine Society Journal (NASSJ) 2025, 22: 100617. PMID: 40548100, PMCID: PMC12182323, DOI: 10.1016/j.xnsj.2025.100617.Peer-Reviewed Original ResearchSickle cell disease patientsSickle cell diseaseSingle-level ACDFAnterior cervical discectomyAdverse eventsCervical discectomyPostoperative complicationsPostoperative outcomesElixhauser Comorbidity IndexCell diseaseSingle-level anterior cervical discectomyEmergency departmentUrinary tract infectionMultiple postoperative complicationsOdds of adverse eventsSerious adverse eventsAcute kidney injuryPostoperative adverse eventsDeep vein thrombosisMinor adverse eventsIndividual adverse eventsDegenerative disc diseaseMultivariate logistic regressionStudent's t-testHigh-risk populationOS-038-YI Urinary neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic and prognostic biomarker of acute kidney injury in patients with decompensated cirrhosis: an individual patient data meta-analysis
Moreta M, Juanola A, Allegretti A, Piano S, Belcher J, Yewale R, Jaques D, Robinson J, Ouyang T, Gambino C, Huelin P, Ariza X, Angeli P, Parikh C, Ramakrishna B, Ponte B, Ginès P. OS-038-YI Urinary neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic and prognostic biomarker of acute kidney injury in patients with decompensated cirrhosis: an individual patient data meta-analysis. Journal Of Hepatology 2025, 82: s32-s33. DOI: 10.1016/s0168-8278(25)00353-8.Peer-Reviewed Original ResearchHospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchConceptsAcute kidney injuryClinician-level variationAssociated with acute kidney injuryAcute kidney injury ratesCardiac surgeryIntraclass correlation coefficientAdult patientsKidney injuryCohort studyCohort study of adult patientsResuscitation practicesPostoperative acute kidney injuryOperating room practiceStudy of adult patientsAssociated with increased morbidityCardiac surgical proceduresCardiac surgical databasePractice variationRBC transfusion ratesFluid volume administrationHospital-level variationMultilevel mixed-effects modelsPatient-level characteristicsRisk-adjustment modelsHealth care costsGlucarpidase for treatment of high-dose methotrexate toxicity
Gupta S, Kaunfer S, Chen K, Dias J, Vijayan A, Rajasekaran A, Prosek J, Truong H, Wood A, Bassil C, Renaghan A, Shah C, Zhang J, Glezerman I, Carlos C, Kelly K, Passero C, Drappatz J, Abudayyeh A, Shin D, Sperati C, Yelvington B, Kanduri S, Neyra J, Edmonston D, Shirali A, Bansal A, Geara A, Mithani Z, Ziolkowski S, Rashidi A, Jakubowski J, Pujari A, Bond D, Dotson E, Wall S, Patton J, Barreto J, Herrmann S, Sheikh M, Baz R, Lee J, Lucchesi N, Kolman M, Rasheed M, Afzal A, Kang D, Mahesh A, Hsu R, Nicolaysen A, Tefera K, Schretlen C, Miller R, Velez J, Flannery A, Aklilu A, Anand S, Chandrasekhara S, Donley V, Patel A, Ni J, Krishnamurthy S, Ali R, Yilmam O, Wells S, Ortega J, Green-Lingren O, Leaf R, Sise M, Nayak L, LaCasce A, Leung N, Leaf D. Glucarpidase for treatment of high-dose methotrexate toxicity. Blood 2025, 145: 1858-1869. PMID: 39760780, DOI: 10.1182/blood.2024026211.Peer-Reviewed Original ResearchAcute kidney injuryHigh-dose methotrexate toxicityKidney recoveryPatients treated with glucarpidaseRates of acute kidney injuryDay 7Time to deathHigh-dose methotrexateCox regression modelsGlucarpidase administrationDialysis-dependentMethotrexate toxicityMethotrexate initiationKidney injuryClinical dataGlucarpidaseCancer CenterNeutropeniaEnd pointsMethotrexatePatientsHospital dischargeOutcomesTarget trial emulation frameworkDaysIdentification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation
Sun S, Ding Y, Yang D, Shen J, Zhang T, Song G, Chen X, Lin Y, Chen R. Identification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation. Frontiers In Medicine 2025, 12: 1502189. PMID: 40166075, PMCID: PMC11955678, DOI: 10.3389/fmed.2025.1502189.Peer-Reviewed Original ResearchHub genesSeptic kidney injuryAcute kidney injurySignaling pathwayDrug-gene interaction databaseKidney injuryAssociated with hub genesGene Ontology biological processesProtein-protein interactionsIntensive care unitPotential hub genesDrug-gene interactionsCandidate genesKEGG pathwaysCytoscape softwareDrug-geneSTRING databaseInfiltration of immune cellsBioinformatics analysisGene screeningSerum creatinine levelsInteraction databasesRelated genesBiological processesGenesAdding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker M, Cantley L. Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury. Journal Of Clinical Investigation 2025, 135: e188358. PMID: 40091836, PMCID: PMC11910233, DOI: 10.1172/jci188358.Peer-Reviewed Original ResearchConceptsAcute kidney injuryTubular epithelial cellsKidney injuryTubular cellsCases of acute kidney injuryImmune-mediated processPersistence of inflammationBiphasic immune responseChronic kidney diseaseCell deathTubular cell injuryLymphocyte subsetsTubular repairCell cycle arrestOutflow obstructionTEC differentiationPreclinical findingsLymphocytic infiltrationProinflammatory macrophagesKidney diseaseModulate inflammationImmune responseActivated macrophagesMetabolic reprogrammingTubular castsOutcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study
Dhodapkar M, Halperin S, Day W, Saifi C, Rubio D, Koumpouras F, Grauer J, Varthi A. Outcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study. North American Spine Society Journal (NASSJ) 2025, 22: 100604. PMID: 40487382, PMCID: PMC12141882, DOI: 10.1016/j.xnsj.2025.100604.Peer-Reviewed Original ResearchPosterior lumbar fusionSystemic lupus erythematosusDiscoid lupus erythematosusSingle-level posterior lumbar fusionPostoperative adverse eventsMinor adverse eventsAdverse eventsIncreased oddsLupus erythematosusLumbar fusionDiagnosis of discoid lupus erythematosusCohort of systemic lupus erythematosusLevel posterior lumbar fusionsMultivariate analysisDiagnosis of systemic lupus erythematosusDiscoid lupus erythematosus patientsUrinary tract infectionPerioperative adverse outcomesSurgical site infectionAcute kidney injuryDeep vein thrombosisNational database studyHistory of infectionSampled adult patientsMultivariate logistic regressionPostoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study
Stannard B, Epstein R, Gabel E, Nadkarni G, Ouyang Y, Lin H, Salari V, Hofer I. Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study. BJA Open 2025, 14: 100384. PMID: 40129614, PMCID: PMC11930183, DOI: 10.1016/j.bjao.2025.100384.Peer-Reviewed Original ResearchPostoperative acute kidney injuryGlomerular filtration rateAcute kidney injuryRenal functionKidney injuryRates of postoperative acute kidney injuryOccurrence of postoperative acute kidney injuryAcute Kidney Injury Network classificationLong-term renal functionRetrospective propensity-matched studyCox modelPropensity-matched cohort studyPersistent renal dysfunctionIncreased hazardKaplan-Meier analysisFollow-up outpatient visitsFollow-up glomerular filtration ratePropensity-matched studyTertiary care hospitalHaemodialysis requirementRenal dysfunctionAdult patientsFiltration rateCohort studyHazard ratioOptimal Magnitude of Blood Pressure Reduction and Hematoma Growth and Functional Outcomes in Intracerebral Hemorrhage
Li Q, Lv X, Morotti A, Qureshi A, Dowlatshahi D, Falcone G, Sheth K, Shoamanesh A, Murthy S, Viswanathan A, Goldstein J. Optimal Magnitude of Blood Pressure Reduction and Hematoma Growth and Functional Outcomes in Intracerebral Hemorrhage. Neurology 2025, 104: e213412. PMID: 39913881, PMCID: PMC11803522, DOI: 10.1212/wnl.0000000000213412.Peer-Reviewed Original ResearchConceptsSystolic blood pressure reductionSystolic blood pressureMagnitude of blood pressure reductionATACH-2 trialHematoma expansionMagnitude of SBP reductionAcute kidney injuryATACH-2Blood pressure reductionIntracerebral hemorrhageMm HgSBP reductionPost hoc analysisFunctional outcomesHematoma growthAntihypertensive Treatment of Acute Cerebral Hemorrhage 2Poor outcomeHoc analysisMedian hematoma volumeModified Rankin Scale scoreSevere intracerebral hemorrhagePressure reductionMultivariable logistic regression assessed associationsRisk of poor outcomesAdmission systolic blood pressureAssociation of Causative Pathogens With Acute Kidney Injury in Adult Patients With Community-Onset Sepsis
Pant P, Chihara S, Krishnamoorthy V, Treggiari M, Messina J, Privratsky J, Raghunathan K, Ohnuma T. Association of Causative Pathogens With Acute Kidney Injury in Adult Patients With Community-Onset Sepsis. Critical Care Explorations 2025, 7: e1219. PMID: 39937578, PMCID: PMC11826047, DOI: 10.1097/cce.0000000000001219.Peer-Reviewed Original ResearchConceptsAcute kidney injuryOdds of acute kidney injuryDevelopment of acute kidney injuryCommunity-onset sepsisAdult patientsKidney injuryAssociated with increased odds of AKICausative pathogenPINC AI Healthcare DatabaseAcute kidney injury riskMultilevel logistic regressionGlobal Outcomes serum creatinine criteriaAssociated with decreased oddsAssociated with increased oddsSerum creatinine criteriaStage 1 AKIStage 3 AKIStage 2 AKIRetrospective cohort studyCritically ill patientsDay of admissionE. coli infectionCommunity-onsetCreatinine criteriaMedian age1599: ASSOCIATION OF ADEQUATE EMPIRIC ANTIBIOTIC THERAPY WITH ACUTE KIDNEY INJURY IN GRAM-NEGATIVE SEPSIS
Ohnuma T, Khandelwal S, Chihara S, Treggiari M, Privratsky J, Wongsripuemtet P, Messina J, Raghunathan K, Krishnamoorthy V. 1599: ASSOCIATION OF ADEQUATE EMPIRIC ANTIBIOTIC THERAPY WITH ACUTE KIDNEY INJURY IN GRAM-NEGATIVE SEPSIS. Critical Care Medicine 2025, 53 DOI: 10.1097/01.ccm.0001105060.93731.0c.Peer-Reviewed Original ResearchClinical outcomes and care for spontaneous bacterial peritonitis: A national cohort study.
Serper M, Tang H, Zhang S, McCullough A, Kaplan D, Taddei T, Mahmud N. Clinical outcomes and care for spontaneous bacterial peritonitis: A national cohort study. Hepatology 2025 PMID: 39879583, DOI: 10.1097/hep.0000000000001251.Peer-Reviewed Original ResearchIn-hospital mortalityImprove care outcomesPopulation-based studyNational cohort studyQuality measuresHazard of mortalityPost-discharge mortalityNational cohort of patientsCare outcomesSpontaneous bacterial peritonitisInformal careHealth systemPatient clinical factorsAcute kidney injuryBundle componentsRecurrent spontaneous bacterial peritonitisNational cohortCohort studyIncidence of stage 3In-hospitalClinical factorsStage 3Cohort of patientsCumulative incidenceBacterial peritonitis
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