Yale Researchers Find That Ubiquitous Protein Plays Lead Role in Cell Survival
Yale researchers have discovered that the protein polycystin 2 protects against cell death, making it a potential target for therapies to treat a variety of diseases of the liver and kidneys, as well as for brain aneurysms, heart disease, and cancer.
Rothlin Is Appointed McConnell Duberg Professor
Carla Vanina Rothlin, PhD, newly named as Dorys McConnell Duberg Professor of Immunobiology, studies the mechanisms that regulate the magnitude and resolution of the immune response. Rothlin is also a professor of pharmacology, a member of the Yale Cancer Center, and a Howard Hughes Faculty Scholar.
Picciotto to be Recognized with Marion Spencer Fay Award
The Institute for Women’s Health and Leadership of Drexel University College of Medicine will award its 2020 Marion Spencer Fay Award to Marina Picciotto, PhD, Charles B.G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology at Yale School of Medicine.
New Strategy for Untreatable Kidney Disease: Targeting Cell Energy
The best hope for people with an inherited form of kidney disease that causes kidney failure is dialysis or a kidney transplant. But a study led by Yale researchers reveals a potential strategy for developing new drug therapies for these patients.
North American Vascular Biology Organization Honors Eichmann and Sessa
The North American Vascular Biology Organization will give its Judah Folkman Award in Vascular Biology to Anne Eichmann, PhD, Ensign Professor of Medicine (Cardiology) and professor of cellular and molecular physiology; and its Earl P. Benditt Award to William Sessa, PhD, Alfred Gilman Professor of Pharmacology and professor of medicine (cardiology).
Department of Pharmacology Mini-symposium on Feb. 11
The Department of Pharmacology is hosting a mini-symposium titled, "The Biology of Endocrine FGFs: From Basic Mechanisms to Therapeutic Opportunities" on Monday, February 11th, 2019 from 9:30am to 12:30pm (TAC N107). This mini-symposium will feature three separate lectures from three distinguished speakers.
Crystallizing discovery on a key target for cancer drugs
Many approved cancer therapies target a protein called epidermal growth factor receptor (EGFR) that regulates many crucial cellular processes and can speed the proliferation of tumor cells. Yale Cancer Center scientists now have made a fundamental discovery about EGFR signaling, reported in the journal Cell, that may open the potential for new types of cancer drugs.
Study finds key protein that binds to LDL cholesterol
A Yale-led research team identified a protein that plays an important role in the buildup of LDL cholesterol in blood vessels. The finding could lead to an additional strategy to block LDL accumulation, which could help prevent or slow the clogging of arteries that leads to heart disease, the researchers said.
A Yale pharmacologist pursues the therapeutic potential of a psychedelic drug
Pharmacologist Gary Rudnick, Ph.D., names coffee as his personal drug of choice. He’s spent most of his career studying the serotonin transporter, a regulator of neuronal signaling, which is inhibited by such drugs as the antidepressants Lexapro and Prozac. But in the last few years, his research has led him to probe the pharmacological potential of a drug off the beaten path: the hallucinogen ibogaine, which is illegal in the United States. Its medical appeal? Anecdotal reports suggesting that the drug can help opiate addicts kick their habits.
AHA awards $2M to visionary scientists
The American Heart Association on Friday awarded its first Merit Awards to fund highly promising investigators who have the potential to move a field of science forward with creative approaches. The awards, each for $1 million doled out over five years, went to a researcher at Duke University School of Medicine and another at Yale University School of Medicine.
Picciotto named editor-in-chief of The Journal of Neuroscience
Marina Picciotto, PhD, Charles B.G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology, and Deputy Chair for Basic Science Research in the Department of Psychiatry, has been named editor-in-chief of The Journal of Neuroscience.
Yale scientist wins international award for discoveries leading to new class of cancer drugs
A Spanish foundation has awarded a major scientific prize to Yale researcher Joseph Schlessinger, PhD, and two colleagues in recognition of their work leading to the first personalized treatments for cancer. The 2015 Frontiers of Knowledge Award in Biomedicine from the Madrid-based BBVA Foundation includes a €400,000 cash prize.
Our antibiotics are no match for superbugs, and it's a 'global crisis,' UN report says
(CNN)Common diseases such as tuberculosis are becoming untreatable while lifesaving medical procedures like surgeries carry increasing risks because of "alarming levels" of resistance to antimicrobial drugs, according to a new United Nations committee report. Resistance to antibiotics, antivirals, antifungals and antiprotozoals, which has been seen in countries of all income levels, is now a "global crisis," the authors wrote.