1989
Identification of two protein kinases that phosphorylate the neural cell-adhesion molecule, N-CAM
Mackie K, Sorkin B, Nairn A, Greengard P, Edelman G, Cunningham B. Identification of two protein kinases that phosphorylate the neural cell-adhesion molecule, N-CAM. Journal Of Neuroscience 1989, 9: 1883-1896. PMID: 2542481, PMCID: PMC6569722, DOI: 10.1523/jneurosci.09-06-01883.1989.Peer-Reviewed Original ResearchConceptsProtein kinaseLarge polypeptidesCytoplasmic domainKinase ICell adhesion moleculeNeural cell adhesion moleculeThreonyl residuesCalmodulin-dependent protein kinase IN-CAMCalcium/calmodulin-dependent protein kinase ICyclic AMP-dependent protein kinaseCyclic GMP-dependent protein kinaseGlycogen synthase kinase-3AMP-dependent protein kinaseCommon phosphorylation sitesGMP-dependent protein kinaseCasein kinase IISynthase kinase-3Protein kinase IN-CAM polypeptidesChicken N-CAMProtein kinase CPrior phosphorylationPhosphorylation sitesAlternative splicing
1987
Cholecystokinin induces a decrease in Ca2+ current in snail neurons that appears to be mediated by protein kinase C
Hammond C, Paupardin-Tritsch D, Nairn A, Greengard P, Gerschenfeld H. Cholecystokinin induces a decrease in Ca2+ current in snail neurons that appears to be mediated by protein kinase C. Nature 1987, 325: 809-811. PMID: 2434859, DOI: 10.1038/325809a0.Peer-Reviewed Original ResearchConceptsProtein kinase CAction of noradrenalineDependent action potentialsKinase CIntracellular injectionSnail neuronsAction potentialsProtein kinaseCardiac muscleCholecystokininSnail Helix aspersaExcitable tissuesProtein kinase C.Low concentrationsCa2Cyclic GMP-dependent protein kinaseHelix aspersaInjectionGMP-dependent protein kinaseKinase C.KinaseNoradrenalineCCK8Neurons
1986
cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones
Paupardin-Tritsch D, Hammond C, Gerschenfeld H, Nairn A, Greengard P. cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones. Nature 1986, 323: 812-814. PMID: 3022154, DOI: 10.1038/323812a0.Peer-Reviewed Original ResearchConceptsIntracellular injectionCyclic GMP-dependent protein kinaseNeuronal membrane permeabilityAbsence of serotoninProtein kinaseSynaptic transmissionNeuronal functionIncrease of Ca2NeuronesCGMP-dependent protein kinaseGMP-dependent protein kinaseSerotoninSnail neuronesCyclic AMPMembrane permeabilityInjectionPhysiological roleProtein phosphorylationCa2CGMPKinaseIntracellular injection of cGMP-dependent protein kinase results in increased input resistance in neurons of the mammalian motor cortex
Woody C, Bartfai T, Gruen E, Nairn A. Intracellular injection of cGMP-dependent protein kinase results in increased input resistance in neurons of the mammalian motor cortex. Brain Research 1986, 386: 379-385. PMID: 3779415, DOI: 10.1016/0006-8993(86)90175-7.Peer-Reviewed Original ResearchConceptsMammalian motor cortexMotor cortexInput resistanceSame cortical areaCyclic GMP-dependent protein kinasePrecruciate cortexIntracellular injectionAwake catsCortical areasMicroM cGMPNeuronsCortexInjectionCGMPGMP-dependent protein kinaseProtein kinase resultsAcetylcholineProtein kinasePresent results
1982
Serum antibodies that distinguish between the phospho- and dephospho-forms of a phosphoprotein
Nairn A, Detre J, Casnellie J, Greengard P. Serum antibodies that distinguish between the phospho- and dephospho-forms of a phosphoprotein. Nature 1982, 299: 734-736. PMID: 6289133, DOI: 10.1038/299734a0.Peer-Reviewed Original Research