Yale Radiology and Psychiatry Researchers Join with Penn Medicine to Create a New Center to Study Opioid Use Disorders
Opioid use disorder has reached epidemic levels in the United States. Over the last two decades, opioid-related overdose deaths increased by more than 50 percent, with nearly 50,000 in 2018, according to the Centers for Disease Control and Prevention. Researchers from Yale School of Medicine (YSM) and Penn Medicine, which comprises the Perelman School of Medicine at the University of Pennsylvania, have created a new center that focuses on neuroimaging to improve our understanding of opioid use disorders and find new treatments.
WHRY funds studies on pain relief, cannabis, and genetic origins of sex differences in disease
WHRY announces funding for first-of-their-kind studies on pain relief, cannabis, and the genetic basis of sex differences across a broad range of ailments, including Alzheimer’s disease and heart disease.Source: YaleNews
PET Imaging of Beta Cell Mass Featured in Journal of Nuclear Medicine
Type 1 diabetes mellitus (T1DM) is characterized by a loss of β-cells in the islets of Langerhans of the pancreas and subsequent deficient insulin secretion in response to hyperglycemia. Development of an in vivo test to measure β-cell mass (BCM) would greatly enhance the ability to track diabetes therapies.Source: The Journal of Nuclear Medicine
Yale-developed test for Alzheimer’s disease directly measures synaptic loss
Yale researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer’s disease. The method, which uses PET imaging technology to scan for a specific protein in the brain linked to synapses, has the potential to accelerate research for new Alzheimer’s treatments, the researchers said. The study was published in JAMA Neurology.
Zhengxin “Jason” Cai, PhD Awarded the Radiopharmaceutical Sciences Council 2018 Berson-Yalow Award
Zhengxin “Jason” Cai, PhD, Assistant Professor at the Yale University PET Center, has been awarded the Radiopharmaceutical Sciences Council 2018 Berson-Yalow Award for his abstract entitled,"In vivo imaging evaluation of a novel F-labeled SV2A PET tracer in nonhuman primates."
Richard E. Carson, PhD, will give the Henry N. Wagner, MD, Lecture as the opening plenary speaker for the 2018 Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
At the opening plenary on Sunday, June 24, at 8:00 am, Richard E. Carson, PhD, will give the Henry N. Wagner, MD, Lecture on Quantitative Nuclear Imaging: Is SUV the Best We Can Do? Carson is professor of radiology, biomedical imaging and biomedical engineering at Yale University. He is also director of the Yale PET Center and director of graduate studies for Yale’s biomedical engineering program. His presentation will cover tracer kinetic analysis methods used for quantitative brain imaging applications, with a focus on synaptic density imaging, why SUV works as well as it does for FDG oncology studies, and imaging challenges faced in non-brain dynamic studies. The Wagner Lectureship commemorates Henry N. Wagner, Jr., MD, a pioneer in nuclear medicine and international leader in the field for more than half century.Source: SNMI
Yale scientists apply new imaging tool to common brain disorders
A Yale-led team of researchers developed a new approach to scanning the brain for changes in synapses that are associated with common brain disorders. The technique may provide insights into the diagnosis and treatment of a broad range of disorders, including epilepsy and Alzheimer’s disease.
Researchers have reported the first in-human assessment of the radiotracer
Researchers Richard E. Carson, PhD, Mika Naganawa, PhD, and colleagues from the Yale School of Medicine, in collaboration with Pfizer, have reported the first in-human assessment of the radiotracer 18F-PF-05270430 – the first PET ligand to exhibit good properties for imaging and quantifying PDE2A in vivo.
Yale brain-imaging innovator wins Fulbright award for research in Israel
Evan D. Morris, PhD, associate professor of diagnostic radiology, of biomedical engineering, and of psychiatry, has been awarded a Fulbright Scholar grant to conduct research and teach next winter at Hadassah Hospital and Hebrew University in Jerusalem.
Preventing diabetes: Yale researchers measure loss of human pancreas cells
A Yale University-led research team has developed a way to measure the loss of insulin-producing islet cells in the human pancreas. The death of those beta cells leads to diabetes. The finding is a crucial step in developing therapies to preserve insulin production and slow or halt the progress of diabetes.
Psychiatric Times Case-Based Psych Perspectives: Managing Patients With Treatment-Resistant Depression
Lisa Harding, MD, Clinical Instructor in the Department of Psychiatry at Yale School of Medicine, recently participated in a discussion, hosted by the Psychiatric Times, aimed at sharing insights in diagnosing treatment-resistant depression [TRD] and reasons for inadequate treatment response with antidepressant therapy.Source: Psychiatric Times
Powers Receives the Carol and Gene Ludwig Award for Early Career Research
Albert Powers, MD, PhD, Assistant Professor of Psychiatry and Psychology, and Medical Director and Associate Director of the Yale PRIME Psychosis Risk Research Clinic, has received the Carol and Gene Ludwig Award for Early Career Research from the Carol and Gene Ludwig Family Foundation.
Physical activity changes during behavioral weight loss treatment by Latinx patients with obesity with and without binge eating disorder
"This study addresses several important areas that are underrepresented in the literature. Notably, this study focused on Spanish-speaking-only Latinx individuals who are underrepresented in treatment research on both binge-eating disorder and on obesity. Understanding the effects of existing treatments in culturally diverse samples is imperative so that treatments can be refined and effectively disseminated more broadly. Additionally, evaluating specific behavioral changes that are components of complex interventions may contribute to a better understanding of ways to enhance treatment outcomes and to guide more targeted dismantling studies," said Carlos Grilo, PhD, Professor of Psychiatry and of Psychology and Director of the Program for Obesity Weight and Eating Research (POWER).Source: Obesity