Ying Chen, MD, PhD

Dr. Chen has a broad background in environmental genetics and molecular toxicology, with specific training and expertise in redox biology, oxidative stress related diseases, and transgenic mouse models of redox dysregulation. Her research over the past ten years utilizes unique animal models and applies the system biology approach integrating multi-omics data and histopathology to understand the mechanistic roles of redox homeostasis in disease conditions related to environmental and dietary exposures.

1. How does redox-elicited modifications of the liver proteome tune cellular response to protect against alcohol-associated fatty liver disease?
2. Does oxidative stress play a mutagenic role in emerging water contaminant 1,4-dioxane-induced liver cancer
3. What is the functional crosstalk between antioxidants in the central nervous system as they relate to neuronal health and disease?
4. What is the translational importance of these new knowledge in risk assessment, disease prevention and treatment?