Matthew Simon, PhD

Associate Professor of Molecular Biophysics and Biochemistry

Departments & Organizations

Molecular Biophysics and Biochemistry

Center for RNA Science and Medicine

Yale Chemical Biology Institute

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)

Yale Chemical Biology Institute


Matt grew up in Ann Arbor, MI and received his Ph.D. in Chemistry from UC Berkeley. He commuted between Berkeley and UCSF, working with Kevan Shokat developing chemical methods to make synthetic chromatin substrates to study the biochemistry of epigenetics. He continued this work as a Helen Hay Whitney Foundation post doctoral fellow in Robert Kingston's laboratory at the Massachusetts General Hospital, where his interests expanded to include large non-coding RNAs and their impact on chromatin. He is part of the Chemical Biology Institute on Yale's West Campus, and The Department of Molecular Biophysics & Biochemistry, where his group's research focuses on developing new chemical and biochemical means of investigating the regulatory roles of non-coding transcription including long non-coding RNAs (lncRNAs) and their influence on chromatin biology.

Education & Training

PhD University of California at Berkeley (2006)
BA Tufts University (1999)

Honors & Recognition

  • Post Doctoral FellowshipHelen Hay Whitney Foundation (2007)

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Contact Info

Matthew Simon, PhD
Lab Location
West Campus
100 West Campus Drive, Ste MIC312

Orange, CT 06477
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Office Locations
West Campus OfficeWest Campus
100 West Campus Drive, Ste MIC312A

Orange, CT 06477
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Science Hill OfficeBass Center
266 Whitney Avenue, Ste Bass 220

New Haven, CT 06511
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Mailing Address
Molecular Biophysics and BiochemistryYale's Chemical Biology Institute
P.O. BOX 27392

West Haven, CT 06516-7392

The Simon Lab