Clinical Trials as Topic; Investigative Techniques; Analytical, Diagnostic and Therapeutic Techniques and Equipment
Public Health Interests
Cardiovascular Diseases; Clinical Trials
I perform clinical trials at Yale related to the treatment and ablation of arrhythmias as well as new cardiac device implants. I also perform clinical and basic science research in the field of pacemaker and defibrillator lead management and extraction.
Extensive Research Description
I am actively involved in clinical and animal research in the field of lead extraction. This involves the research of venous biology which results in the adherence and fibrosis of pacemaker and defibrillator leads. We collect tissue from the devices we extract and are trying to elucidate the mechanisms of tissue fibrosis and binding of leads to cardiac structures. In addition we perform research in the field of pacemaker and ICD infections. This includes using electronic medical systems to identify infected patients, identifying high risk features of individuals with cardiac device infections, and developing algorithms for best practice management of these patients to optimize outcomes. I also perform animal research to look at lead and cardiac structure interaction in a porcine model. Specifically we are trying to develop an animal model with accelerated fibrosis of pacemaker and defibrillator leads. This would allow us to study the biology of lead fibrosis, train other physicians in the techniques of lead extraction and develop and evaluate extraction tools. I have developed a rescue balloon to be used in extraction cases if there is a tear of the SVC. This balloon's purpose is to stabilize the patient so surgical repair can be performed. I developed it in animals and further evaluated its safety and efficacy in a multicenter trial in which Yale was the primary center. It is now the only rescue tool in extraction and is being routinely used on an international level.
Percutaneous occlusion balloon as a bridge to surgery in a swine model of superior vena cava perforation.
Clancy JF, Carrillo RG, Sotak R, Ram R, Ryu RK, Kennergren C. Percutaneous occlusion balloon as a bridge to surgery in a swine model of superior vena cava perforation. Heart Rhythm : The Official Journal Of The Heart Rhythm Society 2016, 13:2215-2220. 2016
2017 HRS expert consensus statement on cardiovascular implantable electronic device lead management and extraction.
Kusumoto FM, Schoenfeld MH, Wilkoff BL, Berul CI, Birgersdotter-Green UM, Carrillo R, Cha YM, Clancy J, Deharo JC, Ellenbogen KA, Exner D, Hussein AA, Kennergren C, Krahn A, Lee R, Love CJ, Madden RA, Mazzetti HA, Moore JC, Parsonnet J, Patton KK, Rozner MA, Selzman KA, Shoda M, Srivathsan K, Strathmore NF, Swerdlow CD, Tompkins C, Wazni O. 2017 HRS expert consensus statement on cardiovascular implantable electronic device lead management and extraction. Heart Rhythm : The Official Journal Of The Heart Rhythm Society 2017, 14:e503-e551. 2017
Incidence and Predictors of Perioperative Complications With Transvenous Lead Extractions: Real-World Experience With National Cardiovascular Data Registry.
Sood N, Martin DT, Lampert R, Curtis JP, Parzynski C, Clancy J. Incidence and Predictors of Perioperative Complications With Transvenous Lead Extractions: Real-World Experience With National Cardiovascular Data Registry. Circulation. Arrhythmia And Electrophysiology 2018, 11:e004768. 2018