Jonathan Siner, MD

Associate Professor Term; Medical Director - Medical Intensive Care Unit, Yale-New Haven Hospital

Research Interests

Intensive Care Units; Pulmonary Medicine; Sepsis; Translational Medical Research

Research Organizations

Internal Medicine: Pulmonary, Critical Care & Sleep Medicine

Office of Cooperative Research

Research Summary

Dr. Siner currently conducts translational research examining the role of circulating growth factors in the sepsis syndrome and their relationship to outcomes in the intensive care unit. Patients with a diagnosis of sepsis are enrolled from the Medical Care Intensive Care Unit at Yale-New Haven Hospital. Plasma and DNA specimens are obtained and extensive clinical data is abstracted and entered into a clinical database. These investigations drawn on the extensive basic science activity conducted in the Pulmonary Section and examine these discoveries in humans with sepsis and ARDS (supported by an award from the CTSA). He was the recipient of an NIH National Research Service Award (NRSA) which supported his investigation of the role of VEGF and HO-1 in cytoprotection from hyperoxia induced acute lung inury. He is a site co-investigator on several ongoing multi-center trials investigating novel treatments for Sepsis, ARDS and Interstitial Lung Disease.

Specialized Terms: Vascular Growth Factors; Sepsis pathophysiology; Host Response to Viral Infections

Selected Publications

Full List of PubMed Publications

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Contact Info

Jonathan Siner, MD
Patient Care Locations
Winchester Chest ClinicFitkin Memorial Pavilion
789 Howard Avenue

New Haven, CT 06519
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Yale Pulmonary & Critical Care MedicineYale New Haven Hospital Saint Raphael Campus
1450 Chapel Street

New Haven, CT 06511
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Yale Pulmonary & Critical Care MedicineYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Mailing Address
Pulmonary, Critical Care & Sleep MedicinePO Box 208057
300 Cedar Street

New Haven, CT 06520-8057