Frederick Sigworth, PhD

Professor of Cellular and Molecular Physiology and of Biomedical Engineering and of Molecular Biophysics and Biochemistry

Departments & Organizations

Cellular & Molecular Physiology: Graduate Program in Cellular and Molecular Physiology | Sigworth Lab

Molecular Biophysics and Biochemistry

Dean's Workshops

High Performance Computation

Interdepartmental Neuroscience Program

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS) | Molecular Medicine, Pharmacology, and Physiology | Neuroscience

Office of Cooperative Research


Fred Sigworth studied applied physics at Caltech and was a graduate student at Yale, working in the neuroscience laboratory of Charles F. Stevens. He received the PhD in physiology from Yale in 1979 and was a postdoc in the laboratory of Erwin Neher in Göttingen, Germany where he was a co-developer of patch-clamp techniques for single-channel electrophysiology. He returned to Yale as a faculty member at Yale in 1984. His current research is in the structural biology of ion-channel proteins, making use of novel cryo-EM methods. "How do I see the scientific enterprise? An old book puts it this way: one generation commends God's works to another. It is a great privilege to unravel the workings of ion channels, and to pass on the excitement about these molecular machines to students, colleagues and anyone else who will listen!"

Education & Training

PhD Yale University (1979)
Research Associate Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Post-Doctoral Fellow Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

Honors & Recognition

  • MemberNational Academy of Sciences (2016)

  • Bohmfalk Teaching PrizeYale School of Medicine (2002)

  • K. C. Cole AwardBiophysical Society (1997)

  • Yale Science and Engineering AwardYale University (1996)

  • Jacob Javits Neuroscience Investigator AwardNIH (1992)

  • FellowAlexander von Humboldt Foundation (1979)

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Contact Info

Frederick Sigworth, PhD
Office Location
Sterling Hall of Medicine, B-Wing
333 Cedar Street, Ste Room BE25A

New Haven, CT 06510
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Mailing Address
Cellular & Molecular PhysiologyPO Box 208026
333 Cedar Street

New Haven, CT 06520-8026

Curriculum Vitae