Fred Sanford Gorelick, MD

Henry J. and Joan W. Binder Professor of Medicine (Digestive Diseases) and of Cell Biology; Director Investivative Gastroenterology NIH T32, Internal Medicine; Deputy Director, Yale M.D., Ph.D. Program

Departments & Organizations

Cell Biology: Membrane Traffic

Internal Medicine: Digestive Diseases: Pancreatic Diseases Program | Investigative Medicine Program | Liver Center

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development

Office of Cooperative Research


After completing medical school and internal medicine training at the University of Missouri, Dr. Gorelick trained at Yale in Gastroenterology. After his clinical training, he began basic science training with Dr. James Jamieson at Yale. During that period he described calcium-calmodulin dependent protein kinase II and subsequently worked with Dr. Paul Greengard (Rockefeller University) to examine the enzyme's mechanism of activation, a response critical to neuronal memory.

His later work has focused on the mechanisms of acute pancreatits and how digestive enzymes, such as trypsin, are activated within the pancreas during this disease. Dr. Gorelick sees patients with gastrointestinal diseases at the VAMC in West Haven, CT. He is also the Deputy Director for the Yale physician Scientist program and directs a year-long course for the group that links basic science to clinical disease. He has also been the Director of the Yale Program in Investigative Gastroenterology for over 10 years. His laboratory at the VA studies the molecular mechanisms related to acute pancreatitis with a goal of developing tools that prevent or lessen disease.

Education & Training

MD University of Missouri (1973)
Visiting Scientist Rockefeller University
Post Doctoral Yale University
GI Fellow Yale University School of Medicine
Resident University of Missouri

Honors & Recognition

  • Lifetime Mentorship AwardAmerican Gastroenterological Association (2019)

  • Howard Spiro Teaching AwardYale Section of Digestive Diseases (2012)

  • American Association of PhysiciansAAMC (2010)

  • William Go Life-time Achievement AwardAmerican Pancreatic Association (2008)

  • Bohmfalk Teaching Award in Basic ScienceYale University (2007)

  • ASCIAmer Soc Clin Investigation (1990)

  • Morton Grossman Research AwardAmerican Gastroenterological Association (1984)

Professional Service

  • DOD PRMRP-P2rmis pancreas (2012 - 2014) Chaired grant review committee and reviewed grant submissions

  • NIH (2009) NIH ZDKi GRB-2 Study Section

  • Yale University (2009 - 2013) Deputy Director Yale MD, PhD Program

  • Yale University School of Medicine (2005 - 2017) Director NIH T32 Training Program in Investigative Gastroenterology

  • National Institutes of Health (2004 - 2006) NIH Study Section Chair (CIGP)

  • NIH NIDDK (2001 - 2004) Full-time member NIH GMA2 grant review committee

  • American Pancreatic Association (1998 - 1999) President

  • American Gastroenterological Association Pancreatic Section (1996 - 2000) Co-chair then chair; organized pancreatic research and state of the art talks on pancreatic diseases for 4 day international meeting.

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Contact Info

Fred Sanford Gorelick, MD
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056

Curriculum Vitae