Clemens Bergwitz, MD
Biography
Research & Publications
Patient Care
News
Locations
Appointments
Biography
Clemens W.H. Bergwitz, MD, is an endocrinologist and Associate Professor of Medicine. In 2006, he identified the genetic defect underlying the childhood disorder Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH), and since then, he has developed a research focus on inborn errors of bone and mineral metabolism. He leads several clinical trials and his lab uses murine models of hypophosphatemia to understand better the responses of the musculoskeletal and renal systems to oral phosphate therapy. Using genome-wide RNAi screens, a more recent research interest is in trying to understand how human and other metazoan cells sense inorganic phosphate and to identify mammalian systems suitable to study identified hits. He also attends the Endocrine Consult Service at Yale New Haven Hospital and, as a member of the Yale Medical Group, sees outpatients with hypophosphatemic disorders, osteoporosis, primary hyperparathyroidism, hyperthyroidism, thyroid nodules, hypogonadism, adrenal, and general endocrine disorders.
Education & Training
- FellowshipMassachusetts General Hospital (2006)
- ResidencyMassachusetts General Hospital (2003)
- FellowshipNICHD, NIH (2001)
- ResidencyHannover Medical School (1999)
- Research FellowshipMassachusetts General Hospital and Harvard Medical School (1996)
- MDHannover Medical School (1993)
- BAWilhelm Gymnasium, Chemistry and Ancient Greek (1986)
Activities
- Workshop on HypophosphatemiaWashington, DC, United States 2024ASBMR Clinical Case Workshop Series
- HHRH and other genetic disorders of phosphate homeostasisPhiladelphia, PA, United States 2024Perlman School of Medicine, UPenn, Philadelphia, PA
- Phosphate sensing and related genetic disordersFarmington, CT, United States 2023Endocrine Grand Rounds UCONN
- Overexpression of the Phosphate Transporter PIT1 in Muscle Promotes Increased Muscle Mass, Energy Expenditure and Endurance Running in Male MiceGalveston, TX, United States 2023Gordon Conference on Physiology, Biology and Pathology of Phosphate
- Phosphate sensing and related genetic disordersDallas, TX, United States 2022Endocrine Grand Rounds UT Southwestern
- TIO and other causes of hypophosphatemiahttps://www.ese-hormones.org/events-deadlines/ese-events/early-bird-deadline-ese-clinical-update-on-calcium-and-bone-2022-online/ 2022European Society of Endocrinology Clinical Update on Calcium and Bone 2022 online webinar series
- Hereditary hypophosphataemic rickets with hypercalciuriaCalgary, AB, Canada 202219th Congress of the International Pediatric Nephrology Association (IPNA 2022)
- Phosphate-sensing and related skeletal disordersMarseille, Provence-Alpes-Côte d'Azur, France 2020European Calcified Tissue Society (ECTS/ICCBH)
- Advances in FGF23 SignallingBrighton, England, United Kingdom 2018British Society for Endocrinology Annual Meeting
- Metabolic and endocrine sensing of phosphate – insights from genetic disordersNantes, Pays de la Loire, France 2017BBC meeting
- Metabolic and endocrine sensing of phosphate – insights from genetic disordersNantes, Pays de la Loire, France 2017BBC2
- Meet the Professor: “Phosphate Sensing: Two Sensors, a Metabolic and an Endocrine One?"Atlanta, GA, United States 2016ASBMR 2016 Annual Meeting
- Disorders of Phosphate Homeostasis and Tissue MineralizationWürzburg, BY, Germany 2016International Expert Workshop on Rare Bone Diseases
- "Genetic approaches to understanding phosphate homeostasis” and "Disorders of Phosphate Homeostasis and Tissue Mineralization”Dresden, SN, Germany 2015Uni-Klinikum Dresden
- Genetic approaches to understanding phosphate homeostasis and Disorders of Phosphate Homeostasis and Tissue MineralizationDresden, SN, Germany 2015Endocrine Grand Rounds and Research Day
- Renal phosphaturia and SLC34A3 mutationsZürich, ZH, Switzerland 2009EUNEFRON
- Renal Sodium-Phosphate Cotransporters in Human DiseaseBethesda, MD, United States 2005NIH Inter-Institute Endocrine Grand Rounds, National Institute of Dental and Craniofacial Research, Craniofacial and Skeletal Diseases Branch, Bethesda, MD
- Linkage analysis for Hereditary Hypophosphatemic Rickets with HypercalciuriaNew Haven, CT, United States 2005PPP8 meeting
Honors & Recognition
Award | Awarding Organization | Date |
---|---|---|
Yale Center for Clinical Investigation Pilot on "The impact of phosphate metabolism on healthy aging" | 2019 | |
O’Brien Center Pilot on “Role of Pyrophosphate in Nephrocalcinosis of Npt2a-/- Mice” | 2016, 2017, 2018 | |
Young Investigator Award on “Role of the renal sodium-phosphate cotransporter NaPi-IIc in phosphate homeostasis” | American Society for Clinical Investigation | 2007 |
Young Investigator Award on “Role of the renal sodium-phosphate cotransporter NaPi-IIc in phosphate homeostasis” | National Kidney Foundation | 2007 |
Young Investigator Award - “Role of the renal sodium-phosphate cotransporter NaPi-IIc in phosphate homeostasis” | National Kidney Foundation | 2007 |
Von-Recklinghausen-Preis | German Endocrine Society | 1996 |
Professional Service
Organization | Role | Date |
---|---|---|
University of Minnesota | Interview by Emilia Zangla and Anne Kouri on "HHRH, diagnosis and treatment" | 2024 - Present |
Pharmacy Practice News, McMahon Publishing Group | Interview with Marcus Banks, Pharmacy Practice News, McMahon Publishing Group, on recent Kidney International publication: An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH). | 2024 - Present |
Scientific American | Interview with Meryl Davids Landau, Award-winning independent journalist, MerylDavidsLandau.com, on “Role of Vitamin D for bone health” | 2024 |
Hypophosphatasia, Alexion/Astra Seneca, Boston, MA, USA | Advisor | 2024 - Present |
Gordon Conference on Physiology, Biology and Pathology of Phosphate | Session Chair | 2023 |
Barron's | Interview with Neal Templin from Barron's on what seniors can do to avoid osteoporosis: “Osteoporosis Affects Many. What to Know—and How to Prevent It.” | 2022 |
Clinical Relevance of IV Iron-Associated Hypophosphatemia, Pharmacosmos Therapeutics Inc., NJ, USA | Advisor | 2022 - Present |
Deutsche Forschungsgemeinschaft (DFG) | Ad-hoc Member | 2021 - Present |
French National Research Agency | Ad-hoc reviewer | 2021 - Present |
Research & Development, Pharmaceuticals Pediatric Development, Bayer AG, Berlin, Germany | Advisor | 2020 - 2022 |
PRMRP Musculoskeletal health (PRE-MSH-1), Department of Defense | Ad-hoc Member | 2020 - Present |
Clinical trials, Beach Pharma, Tampa, FL, USA | Advisor | 2020 - Present |
Nature Scientific Reports | Guest Editor | 2019 - 2021 |
Skeletal Biology Development and Disease (SBDD), NIH | Ad-hoc Member | 2017 - Present |
Sponsored Research, Nutricia North America, Rockville, MD, USA | Investigator | 2017 - 2022 |
Association of Osteobiology | Member | 2016 - Present |
Advances in Mineral Metabolism (AIMM) | Board Member | 2016 - Present |
ASBMR Annual Meeting, Washington, DC | Moderator of one scientific session | 2007 - Present |
American Society of Bone and Mineral Research (ASBMR) | Member | 1993 - Present |