The structure, function, and pharmacologic inhibition of FGF23

Research Faculty & Summary

Joseph Schlessinger, Principal Investigator
V.P. Eswarakumar, Co-investigator

FGFs mediate their responses by binding to and activating a family of four receptor tyrosine kinases (FGFRs 1 – 4). FGFRs 1 – 3 have two isoforms produced by alternate splicing which differ in their ligand-binding specificities and tissue expression patterns.

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Identification of Klotho interacting site of c-type FGFRs. Two major isoforms of FGFRs, the b and c, are produced by alternate splicing of exons 8 and 9, respectively. The location of putative Klotho interacting residues, Glycine 345, Phenylalanine 352 and Histidine 353, on the c-isoforms is marked by the arrow.