Yale University Investigative Medicine Courses
Fellows take courses in their second and third year. All fellows take Principles of Clinical Research and Introduction to Biostatics.
Fellows may elect to take additional courses
Section 1: Genomics
Genomics describes the determination of the nucleotide sequence as well as further analyses used to discover functional and structural gene information on all the genes of an organism. The term proteome refers to all the proteins expressed by genome, and thus proteomics involves the identification of proteins in cells and the determination of their role in physiological and pathophysiological functions. When used in combination, these two approaches enable researchers to analyze gene function at many levels. In this section, students will become familiar with both the underlying theory and the practical application of genetic sequence analysis. Lectures will be supplemented with computer laboratory sessions to reinforce these ideas and to provide practical experience. Topics include the methods and results of analysis on a genome-wide scale as well as a discussion of the implications of this research in medicine.
Section 2: Structure-Based Drug Design
In this section, students will learn the underlying principles in structure based drug design. Lectures will be supplemented with computer laboratory sessions devoted to practical learning of basic principles in protein structure determination, analysis and relationship to molecular drug design. Clinically relevant examples of this approach will be considered.
Fellows can participate in courses and advanced degree programs leading to an MPH (Yale School of Epidemiology and Public Health) or PhD (Yale Investigative Medicine Program). The Investigative Medicine Program also offers a Masters in Health Sciences degree. This innovative program is directed exclusively to physicians serving as fellows in clinical departments and emphasizes either disease-oriented or patient-oriented research. The Yale Robert Wood Johnson Program offers additional Training in Clinical Epidemiology. Fellows who wish to pursue additional laboratory or advanced clinical research have the option to pursue a fourth year to complete their research projects.