2001
Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein1
Weinzimer S, Gibson T, Collett-Solberg P, Khare A, Liu B, Cohen P. Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1806-1813. PMID: 11297622, DOI: 10.1210/jcem.86.4.7380.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCarrier ProteinsCell DivisionCells, CulturedDose-Response Relationship, DrugFluorescent Antibody TechniqueHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsIronKineticsMaleMicroscopy, ConfocalMuscle, SmoothProstatic NeoplasmsSheepTissue DistributionTransferrinUrinary BladderYeastsConceptsIGFBP-3IGFBP-3-induced apoptosisInsulin-like growth factorBladder smooth muscle cellsHuman liver complementary DNA libraryProstate cancer cellsSmooth muscle cellsImportant physiological effectsIGF actionBinding proteinProteins/receptorsMuscle cellsProtein 3Growth factorCancer cellsCell proliferationTF treatmentPhysiological effectsNegligible affinityHuman serumTransferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein
Weinzimer SA. Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1806-1813. DOI: 10.1210/jc.86.4.1806.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCarrier ProteinsCell DivisionCells, CulturedDose-Response Relationship, DrugFluorescent Antibody TechniqueHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsIronKineticsMaleMicroscopy, ConfocalMuscle, SmoothProstatic NeoplasmsSheepTissue DistributionTransferrinUrinary BladderYeastsConceptsIGFBP-3IGFBP-3-induced apoptosisInsulin-like growth factorBladder smooth muscle cellsHuman liver complementary DNA libraryProstate cancer cellsSmooth muscle cellsImportant physiological effectsIGF actionBinding proteinProteins/receptorsMuscle cellsProtein 3Growth factorCancer cellsCell proliferationTF treatmentPhysiological effectsNegligible affinityHuman serum
2000
Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis*
Liu B, Lee H, Weinzimer S, Powell D, Clifford J, Kurie J, Cohen P. Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis*. Journal Of Biological Chemistry 2000, 275: 33607-33613. PMID: 10874028, DOI: 10.1074/jbc.m002547200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisBinding SitesCloning, MolecularCOS CellsInsulin-Like Growth Factor Binding Protein 3Molecular Sequence DataReceptors, Retinoic AcidResponse ElementsRetinoid X ReceptorsTranscription FactorsTranscription, GeneticConceptsIGFBP-3Insulin-like growth factor-binding protein-3IGFBP-3-induced apoptosisInsulin-like growth factor-binding proteinsGrowth factor-binding proteinsRXR response elementsNuclear receptor retinoid X receptorFactor-binding proteinProstate cancer cellsReceptor retinoid X receptorRetinoid X receptorX receptorProtein 3Direct functional interactionCancer cellsRXR ligandsTranscriptional signalingApoptosisResponse elementTranscriptional activityFunctional interactionSignalingKnockout cellsCellsReceptorsHuman Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3
Mannhardt B, Weinzimer S, Wagner M, Fiedler M, Cohen P, Jansen-Dürr P, Zwerschke W. Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3. Molecular And Cellular Biology 2000, 20: 6483-6495. PMID: 10938125, PMCID: PMC86123, DOI: 10.1128/mcb.20.17.6483-6495.2000.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBlotting, NorthernCell DivisionCell LineCells, CulturedDose-Response Relationship, DrugFluorescent Antibody TechniqueGlutathione TransferaseHumansInsulin-Like Growth Factor Binding Protein 3KeratinocytesOncogene Proteins, ViralPapillomavirus E7 ProteinsPrecipitin TestsProtein BindingRecombinant Fusion ProteinsTime FactorsTransfectionTumor Cells, CulturedTumor Suppressor Protein p53Two-Hybrid System Techniques
1999
Serum IGF‐I and IGFBP‐3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours
Weinzimer S, Homan S, Ferry R, Moshang T. Serum IGF‐I and IGFBP‐3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours. Clinical Endocrinology 1999, 51: 339-345. PMID: 10469014, DOI: 10.1046/j.1365-2265.1999.00804.x.Peer-Reviewed Original ResearchConceptsIGF-binding protein-3Hypothalamic/chiasmatic gliomaIGFBP-3 levelsGrowth hormone deficiencyBody mass indexPrimitive neuroectodermal tumorHypothalamic-chiasmatic gliomaProvocative GH testingIGFBP-3 concentrationsIGF-I levelsGH deficiencyGH testingHormone deficiencySerum IGFBrain tumorsPubertal stageTumor typesLower IGFBP-3 levelsNormal IGF-1 levelsLow IGF-I levelsGrowth factor insulin-like growth factorInsulin-like growth factorIGF-1 levelsRetrospective case reviewBone age delay