2019
How I treat sickle cell disease with hematopoietic cell transplantation
Stenger E, Shenoy S, Krishnamurti L. How I treat sickle cell disease with hematopoietic cell transplantation. Blood 2019, 134: 2249-2260. PMID: 31697818, PMCID: PMC6923666, DOI: 10.1182/blood.2019000821.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationSickle cell diseaseCell transplantationCell diseaseOrgan dysfunctionSCD patientsSignificant morbidityEarly mortalityClinical trialsAvailable cureSCD recipientsAlternative donorsIndividual patientsClinical practicePatientsTransplantationClinical vignettesDiseaseOutcomesMorbidityDysfunctionMortalityTrialsRecipients
2009
Severe Sickle Cell Disease—Pathophysiology and Therapy
Buchanan G, Vichinsky E, Krishnamurti L, Shenoy S. Severe Sickle Cell Disease—Pathophysiology and Therapy. Transplantation And Cellular Therapy 2009, 16: s64-s67. PMID: 19819341, PMCID: PMC2832723, DOI: 10.1016/j.bbmt.2009.10.001.Peer-Reviewed Original ResearchConceptsSickle cell diseaseHematopoietic stem cell transplantationMarrow Transplant Research databaseSickle cell disease pathophysiologyStem cell transplantationCare of patientsModalities of therapyConservative managementInternational BloodCell transplantationTreatment modalitiesChronic illnessCell diseaseSCD manifestationsResearch DatabaseDisease pathophysiologyDiseaseTherapySignificant riskPatientsTransplantationBabiesPsychosocial costsModalitiesMorbidity
2007
Hematopoietic cell transplantation for sickle cell disease: state of the art
Krishnamurti L. Hematopoietic cell transplantation for sickle cell disease: state of the art. Expert Opinion On Biological Therapy 2007, 7: 161-172. PMID: 17250455, DOI: 10.1517/14712598.7.2.161.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationSickle cell diseaseCell transplantationCell diseaseReduced-intensity conditioning regimenIndication of transplantationImpact of transplantationStem cell transplantationPossibility of cureEffect of treatmentConditioning regimenPreparative regimensPulmonary hypertensionBlood transfusionConsiderable morbidityPediatric patientsOrgan damagePremature mortalityTransplantationNatural historyMorbidityMortalityDiseaseStem cellsSafe useHEMATOPOIETIC CELL TRANSPLANTATION: A Curative Option for Sickle Cell Disease
Krishnamurti L. HEMATOPOIETIC CELL TRANSPLANTATION: A Curative Option for Sickle Cell Disease. Pediatric Hematology And Oncology 2007, 24: 569-575. PMID: 18092247, DOI: 10.1080/08880010701640531.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCell transplantationCell diseaseReduced intensity conditioning regimenIndication of transplantationHematopoietic cell transplantationImpact of transplantationIntensity conditioning regimenStem cell transplantationPossibility of cureEffect of treatmentConditioning regimenPreparative regimenPulmonary hypertensionCurative optionBlood transfusionConsiderable morbidityPediatric patientsRelated morbidityOrgan damagePremature mortalityTransplantationNatural historyMorbidityRegimen