2023
Regimen Intensity and Age Affect Transplant-Related Outcomes after Matched Related Donor Hematopoietic Cell Transplantation for Sickle Cell Disease: A STAR Registry Study
John T, Chellapandian D, Shah R, Gillespie S, Liu K, Xiang Y, Bhatia M, Chaudhury S, Eckrich M, Guilcher G, Jaroscak J, Kasow K, Krajewski J, Ngwube A, Olson T, Rangarajan H, Horan J, Krishnamurti L, Shenoy S, Abraham A, Stenger E. Regimen Intensity and Age Affect Transplant-Related Outcomes after Matched Related Donor Hematopoietic Cell Transplantation for Sickle Cell Disease: A STAR Registry Study. Blood 2023, 142: 4904. DOI: 10.1182/blood-2023-182532.Peer-Reviewed Original ResearchHematopoietic cell transplantationRejection-free survivalAnti-thymocyte globulinSickle cell diseaseRelated donor hematopoietic cell transplantationDonor hematopoietic cell transplantationBu/CyShorter hospital stayCumulative doseSevere GVHDHospital stayOverall survivalCell transplantationCell diseaseDay 5Grade III/IVBu/cyclophosphamideBu/FluUse of alemtuzumabKaplan-Meier methodCurrent clinical trialsRisk of rejectionSmall cohort sizeSevere clinical phenotypeConditioning chemotherapy
2005
Unrelated Cord Blood Transplantation (UCBT) in Children with Sickle Cell Disease (SCD): US Centers Experience.
Adamkiewicz T, Haight A, Mazur M, Baker K, Szabolcs P, Kedar A, Chiang K, Krishnamurti L, Wagner J, Wingard J, Yeager A. Unrelated Cord Blood Transplantation (UCBT) in Children with Sickle Cell Disease (SCD): US Centers Experience. Blood 2005, 106: 2044. DOI: 10.1182/blood.v106.11.2044.2044.Peer-Reviewed Original ResearchUnrelated cord blood transplantationAnti-thymocyte globulinSickle cell diseaseHigh-risk sickle cell diseaseReduced-intensity regimensMycophenolate mofetilYo maleDonor engraftmentAutologous reconstitutionDonor originReduced-intensity preparative regimenUnrelated cord blood unitsAcute grade IIIConventional myeloablative regimensExtensive chronic GVHDGrade 1 mucositisGrade III mucositisGrade IV GVHDMyeloablative preparative regimensParainfluenza 3 infectionSevere acute GVHDSustained donor engraftmentTotal lymphoid irradiationTransfusion-induced alloimmunizationElevated liver enzymesMatched Sibling Donor Hematopoietic Cell Transplantation for Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Can Lead To Stable Long Term Engraftment.
Krishnamurti L, Wu C, Baker K, Wagner J. Matched Sibling Donor Hematopoietic Cell Transplantation for Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Can Lead To Stable Long Term Engraftment. Blood 2005, 106: 3172. DOI: 10.1182/blood.v106.11.3172.3172.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseDaily x 5 daysIntensity conditioning regimenCell diseaseConditioning regimenDay 100Stable long-term engraftmentLong-term engraftmentRIC regimenClinical characteristicsCell transplantationDay 180Term engraftmentHigh-risk sickle cell diseaseDonor hematopoietic cell transplantationLineage-specific chimerism analysisPeripheral blood genomic DNARegimen-Related ToxicitiesAnti-thymocyte globulinGroup of patientsChronic graftDonor erythropoiesisGVHD prophylaxisHost disease